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New images of LSD1 enzyme in action shed light on gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells--regulate their genes.

5 Jun 2020

New leukemia immune profiles predict drug resistance, positive responses to immunotherapy

By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), researchers have identified new immune classes of the disease that predict the likelihood of drug resistance and positive responses to immunotherapy.

5 Jun 2020

Comparing genomes to understand how mutations affect the COVID-19 pandemic

Now, a new study by researchers at the Massachusetts Institute of Technology and the Center for Computational Biology, Flatiron Institute and published online on the bioRxiv preprint server describes how the use of comparative genomics helps to identify protein-coding and non-coding functional genes.

4 Jun 2020

SARS-CoV-2 gene deletions may cause milder infections and increase human-to-human transmission

In their recent paper released on the bioRxiv preprint server, a research group from Spain demonstrated how genome changes and deletions in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could represent a strategy of natural selection used for lessening the impact of infection in order to increase viral transmission potential.

4 Jun 2020

UIC Center for Alcohol Research in Epigenetics receives $8.2 million NIH grant

The University of Illinois at Chicago received $8.2 million from the National Institute on Alcohol Abuse and Alcoholism to continue the Center for Alcohol Research in Epigenetics and its research on how alcohol affects genes through epigenetics -- chemical changes to DNA, RNA or proteins that alter the expression of genes without directly modifying them.

4 Jun 2020

Exploring the molecular landscape of the aortic niche and beyond

Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta that supports the generation of the first Hematopoietic Stem Cells (HSCs) in the embryo.

4 Jun 2020

Scientists provide clarity into how cells remember their identity

Cancer is often the result of DNA mutations or problems with how cells divide, which can lead to cells "forgetting" what type of cell they are or how to function properly.

4 Jun 2020

Researchers discover novel gene involved in DNA damage repair and male fertility

A research group from the Institute of Molecular Embryology and Genetics at Kumamoto University, Japan has discovered that the gene C19ORF57 plays a critical role in meiosis.

4 Jun 2020

New risk genes for problematic alcohol use discovered

Do you have what is known as problematic alcohol use? Then statistically you will also be particularly genetically predisposed to develop e.g. depression and insomnia. And to become dependent on drugs and tobacco. This is shown by a new international study in which researchers from iPSYCH are involved.

4 Jun 2020

Human protein plays key role in transcription and genome integrity

Researchers from the University of Seville and Cabimer discover that the UAP56/DDX39B protein remove DNA-RNA hybrids from the genome

4 Jun 2020

Computational models predict known biomarkers of inherited metabolic diseases

We are all unique. Our health is determined by our inherent genetic differences combined with our lifestyles and the environments in which we live.

4 Jun 2020

Small protein has a large impact on bacterial gene regulation

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding protein ProQ is involved in the activation of more than 250 bacterial genes.

4 Jun 2020

Diet and gut microbiome affect outcomes of chemotherapy

What we eat can affect the outcome of chemotherapy – and likely many other medical treatments – because of ripple effects that begin in our gut, new research from the University of Virginia suggests.

4 Jun 2020

New technique opens the door to treating genetic forms of hearing loss

Using a new genetic engineering technique, known as base editing, researchers from Boston Children's Hospital and the Broad Institute of MIT and Harvard, have restored hearing in mice with a known recessive genetic mutation.

3 Jun 2020

Scientists uncover why developing nerve cells take a wrong turn

A group of scientists from CECAD, the Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' have found a mechanism by which neurodevelopmental diseases concerning neurons can be explained: The loss of a certain enzyme, UBE2K, impeded the differentiation of stem cells by silencing the expression of genes important for neuronal differentiation and, therefore, the development and generation of neurons.

3 Jun 2020

Blood group type may affect susceptibility to COVID-19 respiratory failure

A group of over 120 researchers from various institutions across Europe has performed the first genome-wide association study to reveal host genetic factors that may contribute to respiratory failure in cases of coronavirus disease 209 (COVID-19).

3 Jun 2020

New test identifies CAD-affected children who may benefit from uridine

Scientists at Sanford Burnham Prebys Medical Discovery Institute and the Centro de Biología Molecular Severo Ochoa in Spain have created a test that determines which children with CAD deficiency - a rare metabolic disease - are likely to benefit from receiving uridine, a nutritional supplement that has dramatically improved the lives of other children with the condition.

3 Jun 2020