Microscopy News and Research

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Researchers develop platform allowing mass-scale production of SARS-CoV-2 mRNA lipid nanoparticle vaccines

Researchers presented a scalable lipid nanoparticle production (SCALAR) platform to develop SARS-CoV-2 mRNA lipid nanoparticle vaccines.

15 Aug 2023

Scientists capture first images of ribosome-modifying enzymes in action

Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes.

14 Aug 2023

Transparent crystal ribcage for real-time imaging of lung function

Researchers develop the ‘crystal ribcage,’ a transparent ribcage for real-time lung imaging at cellular resolution.

14 Aug 2023

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Researchers explored the structural basis of agonist specificity of α1A-adrenergic receptors (α1-ARs).

14 Aug 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

New mechanism discovered for coordinating organ development

Researchers at the Instituto Gulbenkian de Ciência (IGC, Oeiras) and Max Planck Institute of Cell Biology and Genetics (MPI-CBG, Dresden) identified a new mechanism that exposes some of the multitasking abilities embryos need to build a functional retina, the sensory part of the central nervous system responsible for vision.

9 Aug 2023

Ebola virus forms "viral factories" to replicate inside host cells

New research in the journal Nature Communications gives scientists an important window into how Ebola virus replicates inside host cells.

9 Aug 2023

Spatially-resolved macrophage phenotyping in liver disease-related research

This review manuscript highlights the relevance of spatially-resolved macrophage phenotyping in liver disease-related research.

8 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

AI-powered Schistoscope could revolutionize diagnosis of parasitic disease

Schistosomiasis, a parasitic disease affecting millions worldwide, poses a significant public health and economic burden, particularly in impoverished regions.

8 Aug 2023

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

B cells or B lymphocytes are an important part of the body's immune system. When healthy B cells are infected with the Epstein-Barr virus (EBV), they undergo growth transformation, a process that immortalizes B cells, leading to their uncontrolled proliferation.

7 Aug 2023

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Multifunctional Ga-based nanoparticles combine cancer phototherapy with immunotherapy

Researchers develop a novel cancer theranostic agent that can covert light energy to heat and in turn destroy cancer cells

4 Aug 2023

New technique enables high-resolution analysis of DNA

Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science.

4 Aug 2023

Dopamine neurons may play a bigger role in motor control than previously thought

Dopamine: It's not just for rewards anymore. In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model.

3 Aug 2023

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Researchers characterizes the structures and functions of potent bispecific antibodies against multiple Omicron subvariants using Cryo-EM.

3 Aug 2023

Intranasally administered SARS-CoV-2 RBD-based nanoparticle vaccine provides protection against lung pathology and viral load

In a recent study, researchers working at Ohio State University in the United States of America (USA) developed an intranasal subunit vaccine.

2 Aug 2023

AirGels: A game-changer for research on respiratory infections

Biofilms are highly resistant communities of bacteria that pose a major challenge in the treatment of infections.

1 Aug 2023

Microscopy News and Research

Researchers develop platform allowing mass-scale production of SARS-CoV-2 mRNA lipid nanoparticle vaccines

Scientists capture first images of ribosome-modifying enzymes in action

Transparent crystal ribcage for real-time imaging of lung function

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

New mechanism discovered for coordinating organ development

Ebola virus forms "viral factories" to replicate inside host cells

Spatially-resolved macrophage phenotyping in liver disease-related research

Mitochondrial protein structure activates cell's integrated stress response

AI-powered Schistoscope could revolutionize diagnosis of parasitic disease

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Multifunctional Ga-based nanoparticles combine cancer phototherapy with immunotherapy

New technique enables high-resolution analysis of DNA

Dopamine neurons may play a bigger role in motor control than previously thought

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Intranasally administered SARS-CoV-2 RBD-based nanoparticle vaccine provides protection against lung pathology and viral load

AirGels: A game-changer for research on respiratory infections

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