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T. gondii parasite employs a sophisticated manipulation to suppress host's immune response

Toxoplasma gondii is best known as the parasite that may lurk in a cat's litter box. Nearly a third of the world's population is believed to live with a chronic Toxoplasma infection.

24 Jan 2020

A single number aids biomedical data scientists in finding deadly cancer cells

Biomedical data scientists at the Stanford University School of Medicine have shown that the number of genes a cell uses to make RNA is a reliable indicator of how developed the cell is, a finding that could make it easier to target cancer-causing genes.

24 Jan 2020

RB1 alterations in cancer cells may lead to treatment resistance

The Cancer Genetics Group of the Josep Carreras Leukaemia Research Institute, led by Montse Sánchez-Céspedes, together with Luis Montuenga from CIMA, and Enriqueta Felip from Vall d'Hebron Hospital, has revealed that inactivation of RB1 through intragenic rearrangements is frequent in lung cancer cells from non-smoking patients with EGFR mutations.

24 Jan 2020

Study uncovers large, giant viruses that belong to NCLDV supergroup

While the microbes in a single drop of water could outnumber a small city's population, the number of viruses in the same drop - the vast majority not harmful to humans could be even larger.

24 Jan 2020

Scientists discover why the cells need acidic lysosomes

Just like the body contains lungs, liver, and lymph nodes, so does each of the body's cells contain tiny specialized organs. Perhaps most peculiar among them are lysosomes--bubble-like sacks that act as part recycling bin, part stomach.

23 Jan 2020

Researchers identify liver fibrosis ‘off switch’ in mice

Chronic alcohol abuse and hepatitis can injure the liver, often leading to a buildup of collagen and scar tissue.

23 Jan 2020

Scientists uncover genetic information of what keeps us healthy

Genetics plays a role in the overall health and well-being of humans. Genes provide instructions for making proteins, which help determine the structure and function of each cell in the body. Aside from determining the characteristics inherited, genes have been linked to many diseases. Scientists have determined the genetic information of health.

23 Jan 2020

New vaccine against African swine fever appears to be more effective than previous vaccines

Government and academic investigators have developed a vaccine against African swine fever that appears to be far more effective than previously developed vaccines. The research appears this week in the Journal of Virology, a publication of the American Society for Microbiology.

23 Jan 2020

Landmark study identifies 102 genes associated with autism risk

In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism. The study also shows significant progress towards teasing apart the genes associated with ASD from those associated with intellectual disability and developmental delay, conditions which often overlap.

23 Jan 2020

Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

Transcriptional scanning in the sperm may regulate rate of human evolution

Maturing sperm cells turn on most of their genes, not to follow their genetic instructions like normal, but instead to repair DNA before passing it to the next generation, a new study finds.

23 Jan 2020

Scientists discover new drug target for prostate cancer in the non-coding genome

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

23 Jan 2020

Scientists call for more effort to map the human exposome

An international team of researchers is calling for a large-scale effort to map the health effects of cumulative exposure to environmental components such as chemical pollutants.

23 Jan 2020

New study gives hope for potentially developing a cure for HIV

HIV latency is considered one of the biggest challenges to developing a cure for the virus.

23 Jan 2020

BHF announces shortlist of four CVD research projects competing for £30 million award

The British Heart Foundation (BHF) today announced its shortlist of four research projects competing for a single £30 million award.

23 Jan 2020

Wuhan coronavirus: Disease timeline and on the ground response

The Wuhan coronavirus or 2019-nCoV, a novel coronavirus, is spreading from China to other countries, with the United States confirming its first case of the potentially fatal disease. The virus has killed 17 people in China, sickening more than 500 people across six countries, and leaving thousands of people in quarantine.

22 Jan 2020

New discovery changes the understanding of gene expression

A group of University of Chicago scientists has uncovered a previously unknown way that our genes are made into reality.

22 Jan 2020

Study finds stress does whiten hair

In most cases, hair starts to gray in the thirties, and becomes pronounced in the fifties, at which time the head is typically crowned with a thatch of white, gray and perhaps some hair of the original color. A new study published January 2020 in the journal Nature, shows that this process is speeded up significantly by acute stress persisting over a period, or by severe trauma.

22 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Aging of urine fertilizer prevents transfer of antibiotic resistance

The use of human urine as fertilizer is an important step towards sustainable agriculture because the starting reagent is free, plentiful and useless in most other contexts. It has been used as such for centuries, but with the current focus on environmental sustainability, the possibility of creating a nutrient cycle is under scrutiny. In other words, sourcing fertilizer from urine can be a green way to supply plants with the nutrients they need.

22 Jan 2020