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Study shows how oxidative damage may contribute to ‘maternal age effect’

For women in their 30s and beyond, the probability of a pregnancy that results in a miscarriage or a Down syndrome pregnancy is staggering with the risk increasing to 1 in 3 by the time a woman reaches her early 40s due to the "maternal age effect," the high incidence of mistakes in chromosome segregation that occur during the cell division process of meiosis, which gives rise to the egg.

19 Oct 2016

Episona unveils first innovative new male fertility test at ASRM 2016

Episona Inc., an epigenetics data company focused on improving outcomes in reproductive health, announced today the launch of Seed, an innovative new male fertility test, at the American Society for Reproductive Medicine Scientific Congress& Expo.

19 Oct 2016

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults.

17 Oct 2016

New global Human Cell Atlas initiative could revolutionise diagnosis and treatment

An ambitious global initiative to create a Human Cell Atlas - a description of every cell in the human body as a reference map to accelerate progress in biomedical science - is being discussed at an International meeting in London this week.

14 Oct 2016

Researchers uncover how vitamins A and C act to modify epigenetic cell memory

Vitamins A and C aren't just good for your health, they affect your DNA too. Researchers at the Babraham Institute and their international collaborators have discovered how vitamins A and C act to modify the epigenetic 'memory' held by cells; insight which is significant for regenerative medicine and our ability to reprogramme cells from one identity to another.

12 Oct 2016

Research on naked mole-rats could pave way for new human pain therapies

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli.

12 Oct 2016

Diamond publishes milestone paper that reveals discovery of genetic triggers behind birth defects

Researchers at the UK's national synchrotron facility, Diamond Light Source, have just published the 5000th scientific paper using data from the facility. This milestone marks a significant step for the synchrotron that is used by over 8,000 scientists each year.

7 Oct 2016

Study offers promise for therapeutic management of fetal and congenital genetic diseases in utero

A breakthrough study by research teams at Rosalind Franklin University of Medicine and Science and Oregon Health & Science University offers promise for therapeutic management of congenital diseases in utero using designer nucleotide sequences that can simply be injected into the fluid surrounding the developing fetus to potentially treat disabling-to-lethal genetic defects.

7 Oct 2016

Coral study provides insight into evolutionary development of mesoderm

Corals first appeared on earth nearly half a billion years ago during the Cambrian Period of the Paleozoic Era. The ancient Greek philosopher Aristotle categorized corals as zoophyta, or "plant-animals", due to their plant-like appearance.

5 Oct 2016

Scientists develop new method to produce embryos from non-egg cells

Scientists have shown for the first time that embryos can be made from non-egg cells, a discovery that challenges two centuries of received wisdom.

3 Oct 2016

Researchers suggest need for human studies to examine effects of cannabinoid use during pregnancy

In this new era of legalized marijuana, far too little research has been conducted on the effect of cannabis on the development of human embryos, say researchers at Georgetown University Medical Center who scoured medical literature on the topic and found what they say is worrisome animal research.

30 Sep 2016

Researchers link RHOX gene mutations to infertility in men

The underlying cause of male infertility is unknown for 30 percent of cases. In a pair of new studies, researchers at University of California San Diego School of Medicine determined that the reproductive homeobox (RHOX) family of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice.

27 Sep 2016

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy.

27 Sep 2016

Synthego introduces CRISPRevolution synthetic sgRNA kit for fast, high-throughput gene editing

Synthego, a leading provider of genome engineering solutions, today announces the world’s first synthetic single guide RNA (sgRNA) CRISPR genome editing kit.

24 Sep 2016

Researchers use novel technique to unravel key mystery of earliest stage of development

A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or "epigenetic") modifications made to the protein packaging of DNA using a small population of cells.

20 Sep 2016

Researchers identify mutant traits in mouse for many human disease genes

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others. The study was published this week in Nature.

19 Sep 2016

Stiff, hypoxic regions of tumors trigger cancer progression

When Hippocrates first described cancer around 400 B.C., he referred to the disease's telltale tumors as "karkinos" -- the Greek word for crab.

13 Sep 2016

Researchers develop novel technique to generate hiNSCs for multiple tissue engineering applications

Tufts University researchers have discovered a new technique for generating rapidly-differentiating human neural stem cells for use in a variety of tissue engineering applications, including a three-dimensional model of the human brain, according to a paper published today in Stem Cell Reports

13 Sep 2016

Steroids for treating infertility in women may have harmful effects on pregnancy and child

Researchers at the University of Adelaide are urging doctors and patients to refrain from using a specific steroid treatment to treat infertility in women unless clinically indicated, because of its links to miscarriage, preterm birth and birth defects.

9 Sep 2016

Skin cells derived from autistic donors grow faster than those from control subjects

Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine.

28 Aug 2016