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Researchers show how dengue virus employs multiple tactics to evade immune detection

For the human body to mount an immune response to a viral infection, host cells must identify the viral invader and trigger a signaling pathway. This signal then prompts the immune system to attack and subdue the pathogen.

19 Apr 2017

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases

Researchers in France have developed a new method that will allow doctors to detect minute amounts of a protein called interferon-a in patient samples.

18 Apr 2017

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

18 Apr 2017

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant.

18 Apr 2017

Research sheds new light on the body's response to high salt intake

When you eat salty food, you get thirsty and drink water. Right? Maybe in the short-term, but within 24 hours, you actually get less thirsty because your body starts to conserve and produce more water.

17 Apr 2017

Research finds diagnostic tests to be less accurate for children with impaired kidney function

Breaking research published today in AACC's Journal of Applied Laboratory Medicine reveals that a number of diagnostic tests are less accurate when performed in pediatric patients with impaired kidney function.

17 Apr 2017

Combination of anti-angiogenic and immune-stimulating therapies can lead to effective cancer treatments

Scientists from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments.

13 Apr 2017

Vascular risk factors increase risk of Alzheimer's disease in late-life, study reveals

A study published in The Journal of the American Medical Association (JAMA) reveals that an increasing number of vascular risk factors such as obesity, high blood pressure, diabetes, high cholesterol, and smoking during midlife contributes to increased brain amyloid levels (protein fragments associated with Alzhemier’s, the most common form of dementia) in later life.

13 Apr 2017

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

13 Apr 2017

Clemson University researcher receives NIH grant to advance study into abdominal aortic aneurysms

One of the top ten killers for men older than 55 is the target of Clemson University research that could lead to a new life-saving therapy and a better way of telling whether surgery is necessary.

12 Apr 2017

Targeted treatment slows progression of two degenerative brain diseases in mice

Scientists report a significant step toward combatting two degenerative brain diseases that chip away at an individual's ability to move, and think.

12 Apr 2017

Gladstone scientists discover common mechanism that links neurodegeneration in young and old

Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF), identified a common mechanism in two forms of neurodegeneration that affect young adults or the elderly.

12 Apr 2017

NIH scientists identify protein complexes involved in promoting HSV infection and reactivation

Herpes simplex virus (HSV) infections last a lifetime. Once a person has been infected, the virus can remain dormant (latent) for years before periodically reactivating to cause recurrent disease. This poorly understood cycle has frustrated scientists for years.

12 Apr 2017

'Human knockouts': Genetics in families reveals basic biology and possible therapeutics for disorders

More than 1,800 individuals carrying loss-of-function mutations in both copies of their genes, so-called "human knockouts," are described in the first major study to be published in Nature this week by an international collaboration led by the Perelman School of Medicine at the University of Pennsylvania and colleagues.

12 Apr 2017

Scientists discover how insulin-producing cells show differences in age

Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets.

12 Apr 2017

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

A microscopic corn-and-shrimp cocktail could eventually make DNA-based vaccinations and cancer-treating gene therapies an easier pill to swallow, according to new research from the University of Nebraska-Lincoln.

12 Apr 2017

Prevention, not cure, may be key to stopping Alzheimer’s disease

It has been 111 years since Auguste D. became the first person described with what is now called Alzheimer's disease.

12 Apr 2017

Transmembrane protein complexes shed light on antibiotic resistance in bacteria

An international team including researchers from MIPT’s Laboratory for Advanced Studies of Membrane Proteins have proposed an explanation of the way bacteria process external signals.

12 Apr 2017

Study may provide insight into how R-LA promotes death of hepatoma cells

A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with a form of alpha-lipoic acid (LA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R enantiomeric form of LA (R-LA) promotes the death of hepatoma cells.

12 Apr 2017

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G Protein News and Research

Researchers show how dengue virus employs multiple tactics to evade immune detection

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Research sheds new light on the body's response to high salt intake

Research finds diagnostic tests to be less accurate for children with impaired kidney function

Combination of anti-angiogenic and immune-stimulating therapies can lead to effective cancer treatments

Vascular risk factors increase risk of Alzheimer's disease in late-life, study reveals

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Clemson University researcher receives NIH grant to advance study into abdominal aortic aneurysms

Targeted treatment slows progression of two degenerative brain diseases in mice

Gladstone scientists discover common mechanism that links neurodegeneration in young and old

NIH scientists identify protein complexes involved in promoting HSV infection and reactivation

'Human knockouts': Genetics in families reveals basic biology and possible therapeutics for disorders

Scientists discover how insulin-producing cells show differences in age

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

Prevention, not cure, may be key to stopping Alzheimer’s disease

Transmembrane protein complexes shed light on antibiotic resistance in bacteria

Study may provide insight into how R-LA promotes death of hepatoma cells

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