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Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

Acute kidney injury linked to increased risk of dementia

Acute kidney injury is associated with an increased risk of developing dementia, according to a new study published in the journal Neurology by researchers at Karolinska Institutet and others.

26 Aug 2024

Discovery of TLNRD1 protein could help better understand Cerebral Cavernous Malformations disease

Researchers have discovered a crucial protein, TLNRD1, that could help us better understand and treat Cerebral Cavernous Malformations (CCM) disease.

23 Aug 2024

FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).

21 Aug 2024

Untreated hypertension increases Alzheimer’s risk, research shows

The effects of hypertension history, antihypertensive use, and BP on the risk of developing Alzheimer's.

20 Aug 2024

New insights into the role of vascular adhesion molecules in cardiovascular diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Vascular Adhesion Molecules (VAMs) appear to play important roles in the development of Cardiovascular Diseases (CVD).

19 Aug 2024

Study confirms the causal effect of PECAM-1 on cardiovascular diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes.

19 Aug 2024

Lecanemab effectively targets amyloid plaques in people with Down syndrome, study finds

People with Down syndrome are likely to develop Alzheimer's disease at a young age, with autopsy studies showing that by age 40 years, the brains of individuals with Down syndrome have amyloid plaques.

19 Aug 2024

$3.3 million study to explore eye health in patients with prediabetes and diabetes

A $3.3 million study at the University of Houston College of Optometry will track the health of patients with prediabetes and diabetes to find out who might develop eye problems and be at risk for future vision loss.

19 Aug 2024

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

The long-term subjective cognitive decline risk associated with Herpes zoster infections.

19 Aug 2024

Infections drive brain volume loss and dementia risk by altering key immune proteins, study reveals

Severe infections are linked to increased brain atrophy, particularly in the temporal lobe, which may elevate dementia risk through immune-related proteins.

15 Aug 2024

Anti-inflammatory diets could lower dementia risk among older individuals with cardiometabolic disorders

Researchers investigated whether anti-inflammatory diets support cognitive functions among cardiometabolic disease (CMD) patients.

15 Aug 2024

Study finds no clinically useful biomarkers for long COVID in routine lab tests

Whether tests in current use were adequate to identify post-acute sequelae of SARS-CoV-2 (PASC).

14 Aug 2024

Decline in psychological wellbeing may signal early mild cognitive impairment

Feeling that your life lacks purpose and that there are few opportunities for personal growth in older age may precede the development of mild cognitive impairment (MCI), a frequent precursor of dementia, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry.

13 Aug 2024

Vascular News and Research

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

Acute kidney injury linked to increased risk of dementia

Discovery of TLNRD1 protein could help better understand Cerebral Cavernous Malformations disease

FDA-approved drug could revolutionize organ transplantation

Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

Untreated hypertension increases Alzheimer’s risk, research shows

New insights into the role of vascular adhesion molecules in cardiovascular diseases

Study confirms the causal effect of PECAM-1 on cardiovascular diseases

Lecanemab effectively targets amyloid plaques in people with Down syndrome, study finds

$3.3 million study to explore eye health in patients with prediabetes and diabetes

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

Infections drive brain volume loss and dementia risk by altering key immune proteins, study reveals

Anti-inflammatory diets could lower dementia risk among older individuals with cardiometabolic disorders

Study finds no clinically useful biomarkers for long COVID in routine lab tests

Decline in psychological wellbeing may signal early mild cognitive impairment

Innovative AI system uses tongue color to identify multiple health conditions

Long COVID's lasting toll: Economic losses, healthcare strain, and the urgent need for better global policies

VA Disrupted Care National Project reveals ongoing decline in vascular surgeries post-pandemic

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Violent dementia patients leave nursing home staffers and residents ‘scared to death’

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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