RNA Sequencing News and Research

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Researchers investigate SARS-CoV-2 specific inflammatory response

New research can confirm that while some of the response from monocytes to SARS-CoV-2 is generic to virus infection, most of it SARS-CoV-2 specific, especially proinflammatory responses.

7 Jan 2022

SARS-CoV-2 differs from other betacoronaviruses in a key IRE1α/XBP1 pathway

SARS-CoV-2 differs from other viruses in the beta coronavirus family in the activation of a key pathway associated with endoplasmic reticulum stress.

3 Jan 2022

Exploring why children have milder COVID-19 infections compared to adults

A new study has revealed that an activated pre-exposure innate interferon response in airways together with significantly reduced systemic interferon-stimulated populations are associated with relatively milder severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children.

23 Dec 2021

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Researchers study influenza and SARS-CoV-2 infection models to identify lung memory B cells during viral infection.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Using fungal vaccine to train stem cells and enhance immune response to infections

The research group Immunology of Fungal Infections at the University of Valencia (UV) has investigated a fungal vaccine with which to train stem cells and hematopoietic progenitors (which produce all the cells of the blood and lifelong immune system) to improve the immune response to infections. The work has been published in the journal Frontiers in Immunology.

16 Dec 2021

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Scientists identified a human monoclonal antibody (mAb), which successfully neutralized or bound all sarbecoviruses tested in vitro.

16 Dec 2021

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

In a new study, researchers developed a bioinformatics pipeline that uses RNA sequencing data to identify altered genes and signaling pathways affected by viral infection.

13 Dec 2021

COVID-19 severity is correlated with T cell receptor repertoire signatures

In a new study published in the bioRxiv* preprint server, researchers found that specific TCR sequences predicted the severity of coronavirus disease 2019 (COVID-19) infection. Additionally, there was evidence of increased CDR3 sequences and changes in k-mer motifs for patients with severe illness.

6 Dec 2021

New bioinformatics method for viral sgRNA analysis

A recent study discusses a bioinformatics method to help identify and explore sgRNAs uncovered in next-generation sequencing data.

2 Dec 2021

Advancing our understanding of T cells to improve cancer therapies

In this interview, News-Medical talks to Dr. Brendan Horton about his latest research which has shed new light on cancer and T cells.

2 Dec 2021

Novel nanopore technique for annotation of SARS-CoV-2 capping sites and understanding sgRNA structure

New research examined SARS-CoV-2 transcripts in order to understand how it expresses its gene products in the infected host.

1 Dec 2021

Researchers genetically map cell types that make up the mouse iris

Johns Hopkins Medicine researchers report they have genetically mapped the cell types that make up the mouse iris — the thin disc of pigmented tissue that, in humans, gives eyes their distinct colors.

30 Nov 2021

Genetic ancestry can explain population-level differences in immune response to the flu virus

A new study aimed at explaining differential susceptibility to viral epidemics reveals that ancestry and associated genetic variation can explain population-level differences in the immune response to the flu virus and perhaps also to COVID-19.

26 Nov 2021

Immune response to influenza virus influenced by genetic ancestry

New research at the University of Chicago has found differences in immune pathway activation to influenza infection between individuals of European and African genetic ancestry.

25 Nov 2021

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Science has the technology to measure the activity of every gene within a single individual cell, and just one experiment can generate thousands of cells worth of data.

23 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors.

21 Nov 2021

Importance of cross-neutralizing antibodies against SARS-CoV-2 variants

A new study published in the journal mBio investigates different antibodies from convalescent donors that bind three separate domains of the SARS-CoV-2 spike. The results of this study suggest that the individuals exposed to the SARS-CoV-2 from the first wave have neutralizing antibodies against current variants.

21 Nov 2021

RNA Sequencing News and Research

Researchers investigate SARS-CoV-2 specific inflammatory response

SARS-CoV-2 differs from other betacoronaviruses in a key IRE1α/XBP1 pathway

Exploring why children have milder COVID-19 infections compared to adults

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Impact of acute kidney injury associated gene expression in human kidney cells

Using fungal vaccine to train stem cells and enhance immune response to infections

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

COVID-19 severity is correlated with T cell receptor repertoire signatures

New bioinformatics method for viral sgRNA analysis

Advancing our understanding of T cells to improve cancer therapies

Novel nanopore technique for annotation of SARS-CoV-2 capping sites and understanding sgRNA structure

Researchers genetically map cell types that make up the mouse iris

Genetic ancestry can explain population-level differences in immune response to the flu virus

Immune response to influenza virus influenced by genetic ancestry

New virtual reality platform could revolutionize the way single-cell omics data is analyzed

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

Importance of cross-neutralizing antibodies against SARS-CoV-2 variants

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