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DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity.

9 Jun 2023

Single virus binds to a single receptor, study reveals

In Europe, the pandemic triggered in 2020 by the SARS-CoV-2 coronavirus is now largely under control. But why this virus is able to spread so efficiently remains unclear. A team of researchers led by Dr. Simone Backes, Dr. Gerti Beliu and Prof. Dr. Markus Sauer of the Julius Maximilians University of Würzburg (JMU) has now shown in a publication in "Angewandte Chemie" that some previous assumptions need to be reconsidered.

8 Jun 2023

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Individuals who are immunocompromised are considered at higher risk for severe or longer disease with COVID-19. Understanding the systemic immune response is vital for research efforts to reduce its effects on multiple organs.

2 Jun 2023

What was SARS-CoV-2 antibody seroprevalence in Italian blood donors?

Researchers evaluated titers and types of severe acute respiratory syndrome coronavirus 2 antibodies in voluntary blood donors.

1 Jun 2023

Experimental decoy provides long-term protection from SARS-Cov-2 infection

An experimental "decoy" provided long-term protection from infection by the pandemic virus in mice, a new study finds.

30 May 2023

National-level comprehensive mapping of high-fatality SARS-CoV-2 outbreaks in nursing homes

Researchers analyzed data from three SARS-CoV-2 outbreaks among nursing homes in Belgium.

24 May 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

COVID's latest twist: New XBB variant gains strength through recombination, outsmarting immunity and amplifying fusogenicity

Research discusses the emergence of a highly diversified SARS-CoV-2 Omicron subvariant called XBB, which is spreading rapidly around the world. XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1, during the summer of 2022.

18 May 2023

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Researchers investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused hyperglycemia.

18 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Deep generative models to generate hypothetical SARS-CoV-2 spike sequences

Scientists explore the use of deep generative models in producing complete instances of as-yet undiscovered SARS-CoV2 Spike protein sequences. The resulting models substantially outperform a state-of-the-art generative model for protein sequences finetuned on SARS-CoV2 data.

14 May 2023

The potential variations in sperm quality of infertile patients during the COVID-19 pandemic

A recent study investigated how SARS-CoV-2 infection affected the semen quality of infertile men in Tunisia.

10 May 2023

Unlocking the puzzle: How ACE2 shapes macrophage responses in COVID-19

A new study investigates whether SARS-CoV-2 can enter and replicate in macrophages and whether ACE2 is involved in these mechanisms.

4 May 2023

Neurological phenotypes induced by SARS-CoV-2 spike protein in neurons

Researchers explored the association between SARS-CoV-2 spike protein and burst activities in neurons.

27 Apr 2023

Research uncovers antibodies that are still effective against new variants of SARS-CoV-2

An anonymous San Diego resident has become a fascinating example of how the human immune system fights SARS-CoV-2.

26 Apr 2023

A rapid and affordable in vitro model to test SARS-CoV-2 susceptibility in animal species

Research investigates the susceptibility of seven bat species to SARS-CoV-2 by expressing their ACE2 receptor in a non-permissive avian cell line. The study found that all seven bat species were susceptible to SARS-CoV-2, but the level of virus replication differed between bat species and virus variants.

24 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Unravelling the factors influencing host tropism of SARS-CoV-2-related bat coronaviruses

Researchers investigated the tropism of SC2r-CoVs infecting Rhinolophus bats.

18 Apr 2023