Aplastic Anemia News and Research

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New research evaluating substantial disease burden of PNH presented at European Hematology Association

Alexion Pharmaceuticals, Inc. today announced new research evaluating the substantial disease burden of paroxysmal nocturnal hemoglobinuria, an ultra-rare blood disorder, in patients worldwide. The International PNH Registry, involving 580 patients from 99 sites in 14 countries as of May 2010, found that the debilitating symptoms and life-threatening complications of PNH are similar across patient populations around the world.

14 Jun 2010

Platelet dosage can be lowered in transfusions for cancer and bone-marrow transplant patients

Physicians may be able to safely lower the platelet dosage in transfusions for cancer and bone-marrow transplant patients without risking increased bleeding, according to new research involving UT Southwestern Medical Center and 28 other medical institutions.

11 Mar 2010

False positives in screening tests

In many jurisdictions, tests for human immunodeficiency virus (HIV) are required screening for pregnant women. Some even suggest screening the entire population for HIV. The rationale is to administer powerful antiretroviral drugs to healthy individuals to "prevent transmission."

10 Mar 2010

Research article on Peliosis hepatis

Peliosis hepatis (PH) is a rare pathological entity. PH varies from minimal asymptomatic lesions to larger massive lesions that may present with cholestasis, liver failure, portal hypertension, avascular mass lesion, or even spontaneous rupture.

9 Dec 2009

Biotime's new subsidiary to focus on clinical development and marketing therapeutic stem cell products in China

BioTime, Inc. (OTCBB:BTIM) announced today that it will organize a new subsidiary, BioTime Asia, Limited, for the purpose of clinically developing and marketing therapeutic stem cell products in the People’s Republic of China, and marketing stem cell research products in China and other countries in Asia.

23 Sep 2009

Cimzia approved in U.S. for rheumatoid arthritis

UCB announced today that the U.S. Food and Drug Administration (FDA) approved Cimzia, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA).

13 May 2009

Discovery of molecule that could improve success of blood stem cell transplants

University of British Columbia researchers have discovered a "molecular key" that could help increase the success of blood stem cell transplants, a procedure currently used to treat diseases such as leukemia, Hodgkin's lymphoma and aplastic anemia.

22 Apr 2009

Transplant program tops in expected one-year survival rate

Fred Hutchinson Cancer Research Center's stem-cell transplant program at the Seattle Cancer Care Alliance (SCCA) was one of only two transplant programs nationwide that consistently outperformed the expected one-year survival rate for unrelated donor transplants, according to an independent report that assessed 122 transplant centers over a five-year period.

12 Apr 2009

Few physicians support private banking of umbilical cord blood

A survey of physicians has found broad support for the position that parents should not bank their newborns' umbilical cord blood in a private blood bank unless another member of the family is at risk for a blood disease that will require a stem cell transplant.

8 Mar 2009

European Commission and US FDA approve intravenous formulation of temozolomide

Schering-Plough Corporation (NYSE:SGP) today announced that the European Commission and the US FDA both approved the intravenous (IV) formulation of temozolomide as an alternative to the already approved oral form of the drug.

5 Mar 2009

Trial shows safety of pre-transplant expansion of umbilical cord blood stem cells

Taking blood stem cells collected from an umbilical cord into the lab and expanding their number before transplanting them to replace a patient's blood supply is as safe as a standard cord blood transplant, researchers reported at the 50th Annual Meeting of the American Society of Hematology.

8 Dec 2008

Researchers identify key step in maturation pathway of telomerase

The Stowers Institute's Baumann Lab has discovered an important step in the maturation pathway of telomerase, the enzyme that replenishes the sequences that are lost at chromosome ends with every cell division.

8 Dec 2008

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus (HPV), according to a study posted online ahead of print by Oncogene.

3 Dec 2008

Findings may aid in bone marrow transplants, blood diseases

New research sheds light on the biological events by which stem cells in the bone marrow develop into the broad variety of cells that circulate in the blood. The findings may help improve the success of bone marrow transplants and develop better treatments for life-threatening blood diseases.

5 Aug 2008

"HiCy" drug regimen reverses multiple sclerosis symptoms in selected patients

A short-term, very-high dose regimen of the immune-suppressing drug cyclophosphamide seems to slow progression of multiple sclerosis (MS) in most of a small group of patients studied and may even restore neurological function lost to the disease, Johns Hopkins researchers report. The findings in nine people, most of whom had failed all other treatments, suggest new ways to treat a disease that tends to progress relentlessly.

10 Jun 2008

Stem cells from a person's own umbilical cord effectively treat blood and immune disorders, juvenile diabetes

Two separate data abstracts displayed at the annual scientific meeting of the AABB - an international association of medical professionals and institutions focused on transfusion, transplantation and cellular therapy - highlight the increasing therapeutic use of autologous (one's own) cord blood stem cells for transplant and regenerative medicine, including treatments for blood and immune disorders, juvenile diabetes and neurological repair.

22 Oct 2007

$Accentia announces investigational new drug application for Revimmune for refractory MS$

Aplastic Anemia News and Research

New research evaluating substantial disease burden of PNH presented at European Hematology Association

Platelet dosage can be lowered in transfusions for cancer and bone-marrow transplant patients

False positives in screening tests

Research article on Peliosis hepatis

Biotime's new subsidiary to focus on clinical development and marketing therapeutic stem cell products in China

Cimzia approved in U.S. for rheumatoid arthritis

Discovery of molecule that could improve success of blood stem cell transplants

Transplant program tops in expected one-year survival rate

Few physicians support private banking of umbilical cord blood

European Commission and US FDA approve intravenous formulation of temozolomide

Trial shows safety of pre-transplant expansion of umbilical cord blood stem cells

Researchers identify key step in maturation pathway of telomerase

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

Findings may aid in bone marrow transplants, blood diseases

"HiCy" drug regimen reverses multiple sclerosis symptoms in selected patients

Stem cells from a person's own umbilical cord effectively treat blood and immune disorders, juvenile diabetes

Accentia announces investigational new drug application for Revimmune for refractory MS

Better understanding of T cell response

High-dose anticancer chemotherapy and total body irradiation during childhood can damage developing teeth

Discovery of new gene FANCM sheds light on repair of damaged DNA

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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