Hyperinsulinemia News and Research

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Hyperinsulinemia, or hyperinsulinaemia is a condition in which there are excess levels of circulating insulin in the blood. It commonly presents in people with diabetes mellitus type 2 or insulin resistance and is often associated with metabolic syndrome.

Promising new strategy for treating human type 2 diabetes

In a mouse study, scientists at Mayo Clinic Florida have demonstrated the feasibility of a promising new strategy for treating human type 2 diabetes, which affects more than 200 million people worldwide.

10 Jun 2011

Promising new strategy for treating human type 2 diabetes

10 Jun 2011

Metformin therapy may protect PCOS women against endometrial cancer

Research led by Warwick Medical School at the University of Warwick has found that Metformin, a drug treatment used to treat diabetes and also in women with Polycystic vary syndrome, may potentially provide protection against endometrial cancer.

5 Apr 2011

Scientists reveal metabolic abnormalities underlying schizophrenia

Scientists in Finland have revealed metabolic abnormalities that are associated with schizophrenia. This may be an important step towards development of a clinical test of the disease.

5 Apr 2011

FDA accepts Merck's JANUMET extended-release formulation NDA for type 2 diabetes

Merck today announced that the New Drug Application (NDA) for the Company's investigational extended-release formulation of JANUMET for type 2 diabetes has been accepted for standard review by the U.S. Food and Drug Administration (FDA). The Company is also moving forward as planned with regulatory filings in countries outside the United States.

12 Jan 2011

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy, but for the first time, researchers observed this finding in only a specific subset of patients - those with estrogen receptor (ER)-positive/HER2-negative disease.

10 Dec 2010

Type 2 diabetes and insulin use associated with CRC risk in men, but not women

There is an association between type 2 diabetes mellitus and colorectal cancer (CRC) among men, but not women, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

19 Oct 2010

Researchers propose Nintendo Wii gaming to control gestational diabetes in women

Many women have trouble finding time to exercise in their busy lifestyles. That's especially true for pregnant women who live in northern climates such as Canada, where the weather can limit outdoor activity during winter months every year. But exercise is critical to managing gestational diabetes, a growing problem that occurs in 2 to 9 per cent of pregnancies.

14 Oct 2010

Metabolism imbalance increases asthma risk in children: Research

Even children of a healthy weight who have an imbalanced metabolism due to poor diet or exercise may be at increased risk of asthma, according to new research, which challenges the widespread assumption that obesity itself is a risk factor for asthma.

17 Sep 2010

Study examines impact of microvascular decompression surgery for type 2 diabetes

A team of Allegheny General Hospital (AGH) physicians led by neurosurgical pioneer Peter Jannetta, MD, has made an important new discovery linking the central nervous system to the onset and progression of type 2 diabetes mellitus.Reporting today in the journal Surgical Neurology International, Dr. Jannetta and his colleagues present evidence from a prospective clinical trial that vascular compression of a section of the brain called the medulla oblongata is a factor in some patients with type 2 diabetes and that microvascular decompression surgery (MVD) may be an effective treatment for the condition.

13 Aug 2010

JANUMET results in greater blood sugar reductions in patients with type 2 diabetes compared to pioglitazone

New data were presented at the American Diabetes Association 70th Annual Scientific Sessions from a study comparing JANUMET (sitagliptin/metformin) to pioglitazone. In this study, JANUMET resulted in significantly greater blood sugar reductions in patients with type 2 diabetes compared with pioglitazone.

28 Jun 2010

Diabetes associated with increased risk of cancer

A new consensus statement of experts assembled by the American Diabetes Association and the American Cancer Society reviews emerging evidence that suggests cancer incidence is associated with diabetes as well as certain diabetes risk factors and treatments. The new report reviews the state of science concerning the association between diabetes and cancer incidence/prognosis; risk factors common to both diseases; possible biologic links between diabetes and cancer risk; and whether diabetes treatments influence the risk of cancer or cancer prognosis.

16 Jun 2010

Preterm birth: Pre-pregnancy obesity and gestational weight gain increase risk

Researchers at Boston University School of Medicine's (BUSM) Slone Epidemiology Center and Boston University School of Public Health (BUSPH) have found that pre-pregnancy obesity and gestational weight gain are associated with an increased risk of preterm birth in African American participants from the Black Women's Health Study. This study currently appears on-line in Epidemiology.

11 Feb 2010

Treating mothers for mild gestational diabetes reduces infant deaths and birth-related complications

Treating pregnant women for mild gestational diabetes resulted in fewer cesarean sections and other serious birthing problems associated with larger than average babies, according to a study conducted in part at the University of North Carolina at Chapel Hill.

1 Oct 2009

Safety profiles of JANUVIA and JANUMET drugs established through clinical development program

Merck has thoroughly reviewed the safety data for sitagliptin, and sitagliptin was not associated with an increase in the incidence of pancreatitis in preclinical studies or in clinical trials of up to two years in duration with more than 6,000 patients.

28 Sep 2009

European CHMP recommends Merck's JANUVIA and JANUMET as add-on to insulin

Merck & Co., Inc., which operates in many countries as Merck Sharp & Dohme (MSD), has received a positive opinion from the European Medicines Agency’s (EMEA) Committee for Medicinal Products for Human Use (CHMP) for JANUVIA® tablets and JANUMET® tablets recommending their use as add-on to insulin for the treatment of type 2 diabetes.

26 Sep 2009

New findings may help identify treatments for diabetes and hyperinsulinemia

By investigating a rare and severe form of diabetes in children, University of Iowa researchers have discovered a new molecular mechanism that regulates specialized pancreatic cells and insulin secretion. The mechanism involves a protein called ankyrin, which UI researchers previously linked to potentially fatal human heart arrhythmias.

9 Sep 2009

Building a bridge from Alzheimer's disease to diabetes and vice versa

Modern societies face the increasing burden of age-related diseases, in particular Alzheimer's disease (AD) and type 2 diabetes (T2D).

12 May 2009

Weight linked to prostate cancer death

New research, funded in part by the Canadian Cancer Society, shows that men suffering from prostate cancer are up to 2 1/2 times more at risk of dying from the disease if they are overweight or obese. The men who participated in the study had been weighed prior to being diagnosed with prostate cancer.

5 Oct 2008

Aggressive management of diabetes with diet, exercise, and medications may improve the survival of cancer patients

Researchers at Fox Chase Cancer Center found no effects of type II diabetes on aggressiveness of prostate cancer but found that long-term survival is worse. The findings were presented at the 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology in Denver, Colo.

16 Oct 2005

Hyperinsulinemia News and Research

Further Reading

Promising new strategy for treating human type 2 diabetes

Promising new strategy for treating human type 2 diabetes

Metformin therapy may protect PCOS women against endometrial cancer

Scientists reveal metabolic abnormalities underlying schizophrenia

FDA accepts Merck's JANUMET extended-release formulation NDA for type 2 diabetes

Obesity is associated with worse outcomes in patients with ER-positive/HER2-negative disease

Type 2 diabetes and insulin use associated with CRC risk in men, but not women

Researchers propose Nintendo Wii gaming to control gestational diabetes in women

Metabolism imbalance increases asthma risk in children: Research

Study examines impact of microvascular decompression surgery for type 2 diabetes

JANUMET results in greater blood sugar reductions in patients with type 2 diabetes compared to pioglitazone

Diabetes associated with increased risk of cancer

Preterm birth: Pre-pregnancy obesity and gestational weight gain increase risk

Treating mothers for mild gestational diabetes reduces infant deaths and birth-related complications

Safety profiles of JANUVIA and JANUMET drugs established through clinical development program

European CHMP recommends Merck's JANUVIA and JANUMET as add-on to insulin

New findings may help identify treatments for diabetes and hyperinsulinemia

Building a bridge from Alzheimer's disease to diabetes and vice versa

Weight linked to prostate cancer death

Aggressive management of diabetes with diet, exercise, and medications may improve the survival of cancer patients

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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