Kinase Inhibitor News and Research

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A protein kinase inhibitor is a type of enzyme inhibitor that specifically blocks the action of one or more protein kinases.

Researchers identify first known patients with BUB1 biallelic mutations

A new study published in Science Advances described the first two patients known to have mutations in both copies of BUB1, a critical gene for cell division.

20 Jan 2022

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

New study results suggest that integrin inhibitors have the potential to both prevent infection with SARS-CoV-2, including the Delta and Omicron variants, and to decrease TGF-β levels, resulting in a decrease in COVID-19 severity, hospitalization, and death, especially in vulnerable and unvaccinated populations.

5 Jan 2022

Potential association between senescence and aging in COVID-19

A review published in Cells discussed characteristics of cellular senescence and its potential role in COVID-19.

9 Dec 2021

Clearing old, dysfunctional cells in fat alleviates diabetes

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers from UConn Health report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

22 Nov 2021

Cycling JAK inhibitors can be effective for treating people with difficult-to-treat rheumatoid arthritis

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that people with difficult-to-treat rheumatoid arthritis who do not have success with one Janus kinase inhibitor (JAK inhibitor) can achieve success either cycling to other JAKi medications or switching to a biologic drug.

2 Nov 2021

Scientists discover key component of cellular malfunction that contributes to growth of tumors

Scientists have homed in on a crucial step within the sequence of chemical reactions that govern regulation of cell division, proliferation and death, and whose malfunction contributes to the growth of tumors.

2 Nov 2021

Can targeting autophagy become a new approach to COVID-19 treatment?

In a recent review, the author discusses autophagy as a contributing mechanism of selected drugs that are currently being evaluated to treat COVID‐19.

25 Oct 2021

Targeted drug shows promising activity in kidney cancer patients with brain metastases

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

21 Oct 2021

Osimertinib offers a hint of added benefit for NSCLC patients who have received adjuvant chemotherapy

Osimertinib was the first drug to be approved for adjuvant treatment after complete tumour resection in adults with stage IB to IIIA non-small cell lung cancer (NSCLC).

2 Oct 2021

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

A new type of targeting chaperon protein HSP70 inhibitor QL47 was recently discovered by a team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences to treat FLT3-ITD-positive acute myeloid leukemia (AML).

27 Sep 2021

Potential covalent SARS-CoV-2 spike protein inhibitors

There remains a significant need for new and effective drugs that can be used to treat COVID-19.

23 Sep 2021

Drug combination could make curative surgery possible for some liver cancer patients

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.

29 Jul 2021

New computational topology strategy to identify existing medicines for treating COVID-19

Researchers from the ESI International Chair of the CEU Cardenal Herrera University (CEU UCH) and ESI Group have just published in scientific journal Pharmaceutics a new computational topology strategy to identify existing medicines that could be applied to treat COVID-19 without waiting for the research and clinical trial phases required to develop a new medicine.

16 Jun 2021

A study on SARS-CoV-2 proteins for the development of COVID-19 drugs

The authors of the review have grouped the virus proteins into three categories, (a) host-entry, (b) self-acting, and (c) host-interacting. Additionally, individual SARS-CoV-2 proteins are evaluated to be either directly targeted by drugs or block virus-host interactions.

16 Jun 2021

Study: COVID-19 vaccines safe for IBD patients

Patients with inflammatory bowel diseases (IBD) do not appear to have increased risk of side effects from the Pfizer or Moderna COVID-19 vaccines, according to a recent Cedars-Sinai study published online and upcoming in print in the American Journal of Gastroenterology.

9 Jun 2021

Two repurposed drugs inhibit SARS-CoV-2 entry factors in a synergistic manner

A preprint paper uploaded to the bioRxiv* server shows how combining drugs targeting different entry factors of the host cell may prevent infection by the virus.

3 Jun 2021

Cdkn1a transcript variant 2 is selectively elevated during natural aging across mouse tissues

Aging published "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1.

3 Jun 2021

Kinase Inhibitor News and Research

Further Reading

Researchers identify first known patients with BUB1 biallelic mutations

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

Potential association between senescence and aging in COVID-19

Clearing old, dysfunctional cells in fat alleviates diabetes

Cycling JAK inhibitors can be effective for treating people with difficult-to-treat rheumatoid arthritis

Scientists discover key component of cellular malfunction that contributes to growth of tumors

Can targeting autophagy become a new approach to COVID-19 treatment?

Targeted drug shows promising activity in kidney cancer patients with brain metastases

Osimertinib offers a hint of added benefit for NSCLC patients who have received adjuvant chemotherapy

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Potential covalent SARS-CoV-2 spike protein inhibitors

Drug combination could make curative surgery possible for some liver cancer patients

New computational topology strategy to identify existing medicines for treating COVID-19

A study on SARS-CoV-2 proteins for the development of COVID-19 drugs

Study: COVID-19 vaccines safe for IBD patients

Two repurposed drugs inhibit SARS-CoV-2 entry factors in a synergistic manner

Cdkn1a transcript variant 2 is selectively elevated during natural aging across mouse tissues

Kinase inhibitors could provide an effective way to treat high-risk leukaemia

Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

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