Palindromic Repeats News and Research

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Scientists determine 5,072 essential human genes

In a recent study published in the journal Cell, researchers examined the phenotypic landscape of multiple elusive essential human genes to create a detailed genotype-phenotype resource outlining the phenotypic consequences of disrupting fundamental cellular processes.

8 Nov 2022

Compact rapid detection kit to test for monkeypox virus shows promising results in new research

In a new study, researchers introduced a compact rapid detection kit that tests for the monkeypox virus using a combination of RPA and CRISPR technology.

24 Oct 2022

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

In a recent study published in the journal Nature Cell Biology, researchers demonstrated the susceptibility of salivary glands to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in vitro using an organoid culture model.

20 Oct 2022

On-site ultrasensitive monkeypox viral testing using CRISPR/Cas12a

In a new study posted to the medRxiv* preprint server, researchers in China developed an MPXV assay combining clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR/Cas) and recombinase-aided amplification (RAA) for the first time.

18 Oct 2022

Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

In a new study, researchers performed a genomic study of confirmed Monkeypox virus (MPXV) cases diagnosed in Spain between 18 May and 14 July 2022.

4 Oct 2022

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia explored the molecular mechanisms of the pulmonary and cardiac complications caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using human stem-cell-derived cardiac and lung cells.

27 Sep 2022

Interactions between SIRT5 and SARS-CoV-2 Nsp14 protein

In a new study, researchers investigated the interactions between sirtuin 5 (SIRT5) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein (Nsp14) protein.

14 Sep 2022

Role of the transketolase-like 1 gene in the development of the modern human brain

In a new study, researchers demonstrated how transketolase-like 1 (TKTL1) gene expression influenced neocortical neurogenesis in modern humans.

12 Sep 2022

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

Techniques used for SARS-CoV-2 detection in body fluids

In a recent review published in the journal Trends in Analytical Chemistry, researchers provided a comprehensive overview of the current techniques used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in bodily fluids.

7 Sep 2022

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Researchers performed the photocatalytic mapping of the SARS-CoV-2 spike protein-host cell membrane interactions.

7 Sep 2022

Study reveals the unique and unconventional way mosquitoes process odors

If you've ever sprayed yourself head to toe in bug repellent, yet still felt like a mosquito magnet, it will come as no shock to you that mosquitoes are very, very good at finding humans to bite.

19 Aug 2022

Host anti-viral factors and pathways regulating SARS-CoV-2 infection

In a new study, researchers identified host anti-viral factors and pathways regulating SARS-CoV-2 infection.

18 Aug 2022

A novel 3D-printed lab-on-a-chip device concurrently detects SARS-CoV-2 nucleic acid and anti-SARS-CoV-2 antibodies in saliva

Researchers described the development and applications of a 3D-printed lab-on-a-chip device that quickly detected the presence of SARS-CoV-2 in patient's saliva.

10 Aug 2022

The impact of gene amplification in virus adaptation through intermediate hosts

Researchers assessed the impact of gene amplification on cross-species adaptation.

12 Jul 2022

Study suggests spironolactone may improve clinical outcomes in COVID-19

Researchers performed an integrative analysis of clinical outcomes and viral entry networks in severe COVID-19 infection.

8 Jul 2022

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Researchers developed a new detection assay for SARS-CoV-2.

1 Jul 2022