Protein Engineering News and Research

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Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered ACE2 to enhance its affinity to RBD in human cells.

17 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

New technology predicts allosteric sites in proteins

A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design.

3 Sep 2020

Carefully engineered spike protein can help develop COVID-19 vaccine

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.

6 Aug 2020

SARS-CoV-2 lured away and trapped by a new decoy version of ACE2

Researchers in the United States and Canada have engineered affinity-optimized “receptor traps” that prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from binding to and infecting cells.

3 Aug 2020

15 young scientists receive Damon Runyon Fellowship Award to pursue cancer research

Grants totaling nearly $3.5 million give early career investigators independence to pursue brave and bold cancer research.

31 Jul 2020

New platform can speed up the development of novel antibiotics

Harmful bacteria react less and less to common antibiotics. The infections they cause are therefore increasingly deadly.

4 Jun 2020

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

SignalChem, a global leader in cell signaling and protein engineering, has been conducting research on new coronaviruses since the outbreak of the virus.

From SignalChem Biotech Inc. 28 May 2020

SMART researchers awarded NMRC funding to develop rapid paper-based COVID-19 tests

Singapore-MIT Alliance for Research and Technology, MIT's research enterprise in Singapore, has received a grant from the National Medical Research Council COVID-19 Research fund for the acceleration of research and development of rapid paper-based serological and diagnostic tests for COVID-19.

18 May 2020

New molecular 'fishing' technology can find individual molecules in blood

Like finding a needle in a haystack, Liviu Movileanu can find a single molecule in blood. Movileanu, professor at Syracuse University, and recently graduated Ph.D. student Avinash Thakur will present their research on Monday, February 17 at the 64th Annual Meeting of the Biophysical Society in San Diego, California.

16 Feb 2020

Research reveals novel way to treat cancers using CAR T cell therapy

Too many patients with cancers like multiple myeloma relapse after treatment. This grim reality motivated researchers at Huntsman Cancer Institute at the University of Utah to try to improve the depth and durability of treatment response in multiple myeloma through a new cancer cell targeting mechanism.

10 Feb 2020

Ludwig Cancer Research study develops a safer CAR-T therapy

A Ludwig Cancer Research study has devised a new type of chimeric antigen-receptor (CAR) T cell - a family of promising immunotherapies for cancer- that can be switched on and off on demand.

3 Feb 2020

First images of new gene editing complex which could upgrade CRISPR

Nobel Prize-winning technique used to capture images of a new gene-editing tool that could improve CRISPR-based tools.

19 Dec 2019

Georgia State professor selected as National Academy of Inventors Fellow

Jenny Yang, a Regents' Professor of chemistry at Georgia State University and the associate director of the Center for Diagnostics and Therapeutics, has been selected as a National Academy of Inventors (NAI) Fellow, the academy board announced on Tuesday.

5 Dec 2019

UC Davis researchers awarded $1.5 million NIH grant for CRISPR cancer treatment

What if, instead of killing cancer cells or cells about to become cancerous, you could deliver a repair package and fix them? UC Davis researchers have just been awarded $1.5 million from the National Institutes of Health to start work towards that goal.

3 Oct 2019

New method developed to address failures in promising anti-cancer drug

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies.

17 Sep 2019

U of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

27 Aug 2019

New method prevents the release of synthetic DNA from genetically modified cells

The method prevents a gene that encodes a synthetic protein from spreading into the wild and stabilizes it so that it cannot mutate and lose its function.

21 Aug 2019

Novel technique could help develop a filter for tainted water and human tissues

Scientists can turn proteins into never-ending patterns that look like flowers, trees or snowflakes, a technique that could help engineer a filter for tainted water and human tissues.

26 Jul 2019

Overexpression of tumor suppressor gene may lead to B-cell lymphoma, study finds

Miguel Gallardo, researcher and coordinator of the H12O-CNIO Haematological Malignancies Clinical Research Unit headed by Joaquín Martínez at the Spanish National Cancer Research Centre, has participated in a study that revealed that hnRNP K overexpression may cause B-cell lymphomas, the most common types of blood cancer.

24 May 2019