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Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Researchers reveal a mechanism of SHP2-mediated tumor immunosuppression

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, the authors of this article performed single-cell RNA sequencing to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts.

21 Sep 2021

Systematic review focuses on women's health associated with menopausal hormone therapy

Treatment with estrogen in menopause is both good and bad for women's health. The picture is complex and the scientific evidence sometimes scanty or only moderately solid, a study shows. University of Gothenburg researchers took part.

20 Sep 2021

Commonly prescribed cholesterol-lowering drugs could be effective in treating ulcerative colitis

There may be good news for the nearly 1 million people battling ulcerative colitis, a type of inflammatory bowel condition with no real cure: Statins, a commonly prescribed cholesterol-lowering drug, seem to be an effective, if unexpected, treatment for the condition, according to a new Stanford Medicine study.

20 Sep 2021

Increased presence of certain bacteria in the gut may indicate colon cancer risk

A study published today in the journal Cell Host & Microbe reported that the increased presence of certain bacteria in a gut biome indicates a greater likelihood that colon polyps will become cancerous.

18 Sep 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Researchers discover new pathway that makes drugs less effective in bowel cancer patients

Leading scientists at the University of Birmingham have discovered a previously unknown pathway that prevents specific drugs from working in patients with bowel cancer.

14 Sep 2021

Study introduces new surgical procedure to treat patients with congenital intestinal malrotation

A Cleveland Clinic study has introduced a new surgical procedure to treat both children and adults with congenital intestinal malrotation, an inherited disorder that can cause the intestines to twist.

14 Sep 2021

Second- or third-degree relatives could influence a person's risk of developing colorectal cancer

Having second- or third-degree relatives with colorectal cancer increases a person's risk of developing the disease, according to the findings of a study led by researchers from the University at Buffalo and the University of Utah.

13 Sep 2021

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome - the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts - can impact us in a variety of different ways, from our metabolism to our mood.

9 Sep 2021

Colonoscopy retroflexion often poorly preformed in practice, study finds

A colonoscopy maneuver to better detect polyps in the right colon is often poorly preformed in practice, according to a Northwestern Medicine study published in BMC Gastroenterology.

8 Sep 2021

New imaging technique uses photonics for early diagnosis of bowel cancer

Early intervention could prevent many of the 160,000 deaths from colon cancer in Europe each year. Colonoscopies, the gold standard for spotting bowel cancer early, can still miss up to 20% of precancerous cells.

7 Sep 2021

Simple, non-invasive tool obviates unnecessary surgery in patients with colorectal cancer

A blood RNA test predicts whether residual tumour cells remain in early-stage colon cancer patients and obviates unnecessary surgery.

6 Sep 2021

Georgia State researcher receives award to investigate the influence of environment on IBD

Dr. Michal Kuczma, a research assistant professor in the Institute for Biomedical Sciences at Georgia State University, has received a three-year, $270,000 Career Development Award from the Crohn's and Colitis Foundation to study environmental influences on gut microbiota, immunity and inflammation.

4 Sep 2021

Research confirms link between antibiotic use and increased risk of colon cancer

There is a clear link between taking antibiotics and an increased risk of developing colon cancer within the next five to ten years. This has been confirmed by researchers at Umeå University, Sweden, after a study of 40,000 cancer cases. The impact of antibiotics on the intestinal microbiome is thought to lie behind the increased risk of cancer.

1 Sep 2021

Maternal obesity during pregnancy may heighten the risk of colorectal cancer in adult offspring

Infants whose mothers were obese during pregnancy may have a heightened risk of developing colorectal cancer later in life, according to new research led by public health experts at The University of Texas Health Science Center at Houston.

27 Aug 2021

Restoring DAXX protein levels may prevent misfolding of rogue proteins known to drive Alzheimer's

For the first time, Penn Medicine researchers showed how restoring levels of the protein DAXX and a large group of similar proteins prevents the misfolding of the rogue proteins known to drive Alzheimer's and other neurodegenerative diseases, as well as certain mutations that contribute to cancers.

26 Aug 2021

The White Ribbon Project comes to UC Davis to acknowledge efforts in tackling lung cancer

Retired linebacker Chris Draft, who played on the 49ers and the Falcons as well as other NFL teams, was at UC Davis Comprehensive Cancer Center on Tuesday, Aug. 24, to acknowledge efforts by the cancer center to tackle lung cancer.

25 Aug 2021

Researchers identify mechanism for formation of rare colorectal cancer subtype

Researchers from Rutgers Cancer Institute of New Jersey, the state's only National Cancer Institute-designated Comprehensive Cancer Center, recently discovered a mechanism to explain what drives the formation of mucinous colorectal adenocarcinoma (MAC), a rare subtype of colorectal cancer (CRC), and has also identified the genes responsible for the regulation of this mechanism.