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New gene therapy cures babies with fatal 'Bubble Boy' disease

A new gene therapy created by US researchers appears to have cured eight infant boys born with a rare genetic disorder referred to as “Bubble Boy” disease.

18 Apr 2019

Timing of food intake influences molecular clock in the liver of mice

The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report April 16 in the journal Cell Reports.

17 Apr 2019

Research sheds light on how leukemia cells become resistant to drugs

Three children Alejandro Gutierrez, MD, treated for leukemia during his fellowship at Boston Children's Hospital still haunt him more than a decade later.

17 Apr 2019

Microbiome science may help doctors to improve treatment for children with IBS

To improve the treatment of children with irritable bowel syndrome, investigators have developed a sophisticated way to analyze the microbial and metabolic contents of the gut.

17 Apr 2019

Two proteins act in concert to maintain a healthy heart in mice, shows study

Two proteins that bind to stress hormones work together to maintain a healthy heart in mice, according to scientists at the National Institutes of Health and their collaborators.

17 Apr 2019

Keto diet - for the military, aging and epilepsy

Ketogenic diet or keto diet has been in the news as a trending diet option for weight watchers and those who wish to lose those extra pounds.

17 Apr 2019

Cancer cells grown in tumor-mimicking environment can help predict the effect of experimental drugs

Before being tested in animals or humans, most cancer drugs are evaluated in tumor cells grown in a lab dish.

17 Apr 2019

Japanese researchers explain how inflammation causes gastric tumors

In 1982, researchers reported a link between chronic gastritis and stomach bacterium Helicobacter pylori, triggering a flurry of research into this newly-identified pathogen.

16 Apr 2019

Yeast strain provides manufacturing boost to low-calorie sweetener derived from lactose

The quest to satisfy the sweet tooth without adding to the waistline has a new weapon in its arsenal: a strain of yeast that can metabolize lactose, the sugar in dairy products, into tagatose, a natural sweetener with less than half the calories of table sugar.

16 Apr 2019

Researchers annotate key neuronal proteins in lamprey genome

The lamprey, an eel-like primitive vertebrate, is a popular organism for neurobiology studies because it has a relatively simple nervous system.

16 Apr 2019

CRISPR-scanning could lead to more effective treatments for cancer

11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors.

16 Apr 2019

Spatial orgnization of the genome can be altered using small molecules

Researchers have discovered that the spatial organization of the genome can be altered using small molecule compounds which are considered as promising anti-cancer drugs.

16 Apr 2019

Researchers complete large analysis of new gene fusion responsible for development of cancers

A consortium of researchers led by Georgetown Lombardi Comprehensive Cancer Center investigators have completed the largest analysis of a new gene fusion they believe is responsible for development of a wide spectrum of cancer types.

16 Apr 2019

Researchers uncover cellular resistance mechanisms to BRAF inhibitors in melanoma

Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive outcomes are not long lasting, due to the development of drug resistance and tumor recurrence.

15 Apr 2019

Restoring function of 'misregulated' cancer-fighting genes

Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became "misregulated" by the disease.

15 Apr 2019

Petting zoos can create a diverse reservoir of multidrug resistant bacteria

New research presented at this year's European Congress of Clinical Microbiology & Infectious Diseases in Amsterdam, Netherlands shows that petting zoos can create a diverse reservoir of multidrug resistant bacteria, which could lead to highly virulent drug-resistant pathogens being passed on to visitors.

15 Apr 2019

Cancer cells use tactics to avoid being recognised by immunotherapy agents

Researchers have found that bowel cancer cells have a mechanism by which they can switch off some key molecules on their surfaces and thus escape being recognised and killed by the immunotherapy agents.

15 Apr 2019

Stem cells from patient's own bone marrow holds great potential for osteoarthritis

Stem cells collected from the patient's own bone marrow holds great interest as a potential therapy for osteoarthritis of the knee because of their ability to regenerate the damaged cartilage.

15 Apr 2019

Novo Biosciences achieves major milestones in its new drug to treat heart disease and DMD

Novo Biosciences Inc., has achieved several major milestones in its mission of bringing its breakthrough drug candidate, trodusquemine, to market as a potential regenerative medicine treatment for heart disease and Duchenne muscular dystrophy.

15 Apr 2019

Potential new therapeutic approach identified for neuroblastoma tumors

Research led by Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health New Orleans School of Medicine, found that a compound named 5'-iodotubercidin (5'-IT) suppresses the growth of neuroblastoma cells and identified a potential new therapeutic approach for the disease.

12 Apr 2019