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Charles River Laboratories Launches Off-the-Shelf Lentiviral Vector Packaging Plasmids

Charles River Laboratories International, Inc. (NYSE: CRL) today announced the launch of its off-the-shelf lentiviral vector (LVV) packaging plasmids, providing a streamlined solution to the challenges associated with plasmid sourcing in cell and gene therapies.

From Charles Rivers Laboratories Cell and Gene Therapy 13 Jun 2023

Study provides a new and promising strategy for future cancer immunotherapies

CD8+ T cells, a vital component of the immune system that provides immunity against cancer, have been the focal point of anti-cancer therapies.

13 Jun 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

Vitamin D deficiency during pregnancy linked to an increased risk of Type 2 diabetes in offspring

Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of Type 2 diabetes in offspring.

13 Jun 2023

Cracking the code: omega-3 and omega-6 fatty acids' impact on glucose metabolism

Researchers explored the impact of omega-3 and -6 fatty acids on glucose metabolism.

13 Jun 2023

Sex differences contribute to age-related inflammation: Study

Older female mice had more immune cells entering areas of the body where they shouldn't according to a new study, demonstrating that sex differences contribute to age-related inflammation that needs to be considered in future research.

13 Jun 2023

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Manipulating white blood cells to eliminate solid tumors

By silencing the molecular pathway that prevents macrophages from attacking our own cells, Penn Engineers have manipulated these white blood cells to eliminate solid tumors.

12 Jun 2023

New cell culture model generates the alveolar macrophage in the lab

Researchers at Texas Biomedical Research Institute have succeeded in generating the lung's most important immune cell, the alveolar macrophage, in the lab.

12 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Researchers create a new method of studying nano-sized particles

Researchers at Karolinska Institutet have created a new method of studying the smallest bioparticles in the body.

12 Jun 2023

Study provides a possible treatment option for prostate cancer resistant to hormone therapy

Prostate cancer is the most-commonly diagnosed malignancy and the second leading cause of cancer death among men in the United States.

12 Jun 2023

Adiposity-associated cancer risk differs based on biological sex

Many studies have linked obesity to an increased risk of cancer, but most have not differentiated the risks between men and women.

12 Jun 2023

Scientists find clues to how we maintain constant blood sugar levels after meals

Scientists from the Berlin Institute of Health at Charité (BIH), along with colleagues from the United Kingdom, have found clues as to how we maintain constant blood sugar levels after we have eaten.

12 Jun 2023

Study raises new hopes for blood cancer patients with an incomplete response to CAR T cell therapy

The aim of immunotherapy strategies is to use cells in the patient's own immune system to destroy tumor cells. CAR T cell therapy is an immunotherapy that is effective in treating blood cancer.

12 Jun 2023

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Researchers at Georgetown University's Lombardi Comprehensive Cancer Center and colleagues who have been exploring the complexities of biochemical pathways involved in cancer development have found that a form of glucose, a type of sugar, is intricately linked to a pathway used to build DNA molecules.

12 Jun 2023

Study offers novel insights into the evolution of multiple myeloma

A new study by researchers at The University of Texas MD Anderson Cancer Center highlights novel insights into the evolution of multiple myeloma from precursor disease, which may help better identify patients likely to progress and develop new interventions.

12 Jun 2023

Fatty fish intake decreases lipophilic index, increases cell membrane fluidity

Eating fatty fish decreased the lipophilic index in people with impaired glucose metabolism or coronary heart disease, according to a new study from the University of Eastern Finland.

12 Jun 2023

Study:Overactive inflammatory response could be at the root of many long COVID cases

An overactive inflammatory response could be at the root of many long COVID cases, according to a new study from the Allen Institute and Fred Hutchinson Cancer Center.

12 Jun 2023

Cell News and Research

Charles River Laboratories Launches Off-the-Shelf Lentiviral Vector Packaging Plasmids

Study provides a new and promising strategy for future cancer immunotherapies

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Vitamin D deficiency during pregnancy linked to an increased risk of Type 2 diabetes in offspring

Cracking the code: omega-3 and omega-6 fatty acids' impact on glucose metabolism

Sex differences contribute to age-related inflammation: Study

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

Manipulating white blood cells to eliminate solid tumors

New cell culture model generates the alveolar macrophage in the lab

Metformin shows promising antiviral activity against SARS-CoV-2

Researchers create a new method of studying nano-sized particles

Study provides a possible treatment option for prostate cancer resistant to hormone therapy

Adiposity-associated cancer risk differs based on biological sex

Scientists find clues to how we maintain constant blood sugar levels after meals

Study raises new hopes for blood cancer patients with an incomplete response to CAR T cell therapy

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Study offers novel insights into the evolution of multiple myeloma

Fatty fish intake decreases lipophilic index, increases cell membrane fluidity

Study:Overactive inflammatory response could be at the root of many long COVID cases

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