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Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

Study aimed to identify the direct pathway that associates integrins with vascular dysregulation during SARS-CoV-2 infection

Researchers demonstrated the role of integrin signaling in vascular dysfunction associated with SARS-CoV-2 infection.

21 Mar 2022

Biological timeline of COVID-19 immune recovery described in new research

In a recent study published on the bioRxiv* preprint server, a group of researchers from the University of California, San Francisco, looked at intra-patient immunological changes over time to see if there were any changes in immune responses associated with successful COVID-19 resolution.

21 Mar 2022

Sex-specific differences in T-cell responses to COVID-19

Researchers evaluate both neutralizing activity and T-cell responses in SARS-CoV-2 infected individuals with mild symptoms linked to a single spreading event.

20 Mar 2022

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Researchers assessed the impact of recombinant accessory protein-deficient severe acute respiratory syndrome coronavirus 2 immunization against SARS-CoV-2 transmission and disease severity.

18 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Immuno-metabolomic signatures that correlate with antigen-specific-T cell response during active COVID-19

Researchers investigate innate and adaptive immune responses at both the early and late stages of SARS-CoV-2 infection.

17 Mar 2022

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Researchers explored neuroinflammation and COVID-19-induced ischemic stroke recovery.

17 Mar 2022

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

Researchers studied the immune responses in Syrian hamsters re-infected with SARS-CoV-2 Delta and B.1 variants three months after the primary infection.

17 Mar 2022

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.

17 Mar 2022

Toxin-producing yeast strains may damage the gut of patients with inflammatory bowel disease

Individual Candida albicans yeast strains in the human gut are as different from each other as the humans that carry them, and some C. albicans strains may damage the gut of patients with inflammatory bowel disease (IBD), according to a new study from researchers at Weill Cornell Medicine.

16 Mar 2022

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Researchers determined the immune signature of the multisystem inflammatory syndrome in children among hospitalized children diagnosed with SARS‐CoV‐2 infection.

16 Mar 2022

SARS-CoV-2 in diabetes pathogenesis

Researchers reviewed the causes of diabetes mellitus, focusing on respiratory viruses, including influenza virus and SARS-CoV-2.

15 Mar 2022

Study evaluates efficacy of isotretinoin in improving COVID-19 outcomes

Researchers evaluated the effectiveness of isotretinoin (13-cis retinoic acid) in improving COVID-19 outcomes.

14 Mar 2022

Current evidence that vitamin D is effective against COVID-19 neurological sequelae

Researchers analyze the available scientific evidence supporting vitamin D as a neuroprotective agent against the neurological sequelae of COVID-19.

14 Mar 2022

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Researchers evaluated the survival benefit conferred by PLEX in patients with severe COVID-19 and cytokine-storm syndrome.

14 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

A new study provides an overview of the use of mathematical modeling to determine severe acute respiratory syndrome coronavirus 2 kinetics.

9 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

Cytokine News and Research

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

Study aimed to identify the direct pathway that associates integrins with vascular dysregulation during SARS-CoV-2 infection

Biological timeline of COVID-19 immune recovery described in new research

Sex-specific differences in T-cell responses to COVID-19

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Immuno-metabolomic signatures that correlate with antigen-specific-T cell response during active COVID-19

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Study reports reduced disease severity in Syrian hamsters during re-infection with SARS-CoV-2 Delta variant

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Toxin-producing yeast strains may damage the gut of patients with inflammatory bowel disease

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

SARS-CoV-2 in diabetes pathogenesis

Study evaluates efficacy of isotretinoin in improving COVID-19 outcomes

Current evidence that vitamin D is effective against COVID-19 neurological sequelae

The impact of PLEX on the survival of patients with severe COVID-19 and the effect on the cytokine release syndrome

Novel genetic relationships with severe SARS-CoV-2

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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