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Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

22 May 2023

Identifying risk biomarkers for a serious side effect of stem cell transplants

Doctors are one step closer to having a risk biomarker to alert them to which of their pediatric stem cell transplant patients are likely to experience a potentially deadly side effect called sinusoidal obstruction syndrome (SOS).

22 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage - a cause and consequence of many diseases.

22 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such as methotrexate (MTX).

22 May 2023

Study could help understand why limiting sugary foods can ease symptoms for IBD patients

Excess sugar hampers cells that renew the colon's lining in a mouse model of inflammatory bowel disease (IBD), according to a new study by University of Pittsburgh scientists.

22 May 2023

Understanding the cause for suboptimal germinal center response in aged mice

Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk.

22 May 2023

Dad’s genome may be playing a bigger role in siblings born with ASD

Cold Spring Harbor Laboratory researchers have flipped the script on autism spectrum disorder (ASD) genetics.

22 May 2023

Honokiol inhibits replication of SARS-CoV-2 in several cell types

A compound called honokiol, which is found in the bark of multiple species of magnolia tree, inhibits replication of SARS-CoV-2 virus in several types of cells, according to a team of researchers in the Netherlands.

22 May 2023

AI-based method predicts small molecule substrates of enzymes

Enzymes are the molecule factories in biological cells. However, which basic molecular building blocks they use to assemble target molecules is often unknown and difficult to measure.

22 May 2023

Newly discovered molecule effectively destroys senescent cells

Over time, the body's cells stop working properly and begin to accumulate, which eventually leads to tissues aging.

22 May 2023

New vaccine concept could lead to a new generation of vaccines against SARS-CoV-2

Researchers at the University of Basel have developed a new approach for a vaccine against COVID-19.

22 May 2023

Cancer researchers join together to fight lethal childhood brain cancer

Virginia Tech researchers with the Fralin Biomedical Research Institute at VTC have joined a Children's National Hospital effort to treat deadly brain tumors with ultrahigh frequency sound waves.

22 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Research introduces FeLab, a responsive hydrogel that combines nanozymes and probiotics for the treatment of Candida vaginitis. FeLab demonstrates effective anti-Candida activity, promotes vaginal mucosa repair, and restores healthy vaginal microbiota, offering a promising therapeutic approach for this condition.

21 May 2023

Breast milk shields newborns: COVID-19 antibodies and microbiota from vaccinated mothers provide dual defense

Research paper discusses the differences in microbiota between high and low IgA subjects after the second dose of the COVID-19 vaccine. The study found that certain microbial features in breast milk can predict levels of anti-SARS-CoV-2 antibodies in breast milk one week post-second dose.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Indirect inhibitors of cellular respiration for treatment of glioblastoma

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."

19 May 2023

MGH researchers identify a potential method for treating fragile X syndrome

New research has identified a potential method for treating fragile X syndrome, a leading cause of autism spectrum disorders that is characterized by an inherited repeat of certain nucleotides within the DNA sequence of the FMR1 gene.

19 May 2023

Cell News and Research

Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Identifying risk biomarkers for a serious side effect of stem cell transplants

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Surviving without glucose: uridine-derived ribose as an alternative energy source

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Study could help understand why limiting sugary foods can ease symptoms for IBD patients

Understanding the cause for suboptimal germinal center response in aged mice

Dad’s genome may be playing a bigger role in siblings born with ASD

Honokiol inhibits replication of SARS-CoV-2 in several cell types

AI-based method predicts small molecule substrates of enzymes

Newly discovered molecule effectively destroys senescent cells

New vaccine concept could lead to a new generation of vaccines against SARS-CoV-2

Cancer researchers join together to fight lethal childhood brain cancer

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

Genetic insights unveil promising therapeutic targets for critical COVID-19

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Breast milk shields newborns: COVID-19 antibodies and microbiota from vaccinated mothers provide dual defense

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Indirect inhibitors of cellular respiration for treatment of glioblastoma

MGH researchers identify a potential method for treating fragile X syndrome

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