Phenotype News and Research

RSS

Machine learning helps researchers uncover cellular control networks

The flow of information between cells in our bodies is exceedingly complex: sensing, signaling, and influencing each other in a constant flow of microscopic engagements. These interactions are critical for life, and when they go awry can lead to the illness and injury.

22 Mar 2017

Researchers develop new software tool to provide fast, accurate quantification of gene expression

A group of computational biological researchers, led by Stony Brook University's Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon — a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads.

22 Mar 2017

Linking RNA to autoimmune diseases

An interview with Dr. Chase Spurlock, CEO, discussing IQuity's research into IncRNAs and how they are linked to autoimmue diseases.

20 Mar 2017

Study describes method to engineer brown adipose tissue from white fat-derived stem cells

Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells.

3 Mar 2017

Immune system defect makes Addison’s patients prone to respiratory infections

Research led by University of Birmingham scientists has found that people suffering from the adrenal disorder known as Addison's disease suffer from an immune system defect which makes them prone to potentially deadly respiratory infections.

1 Mar 2017

New investigational drug may help combat antibiotic-resistant global health threat

The deadly fungus, Candida auris, which has been found in hospitals, is resistant to entire classes of antimicrobial drugs, limiting treatment options for those infected.

24 Feb 2017

First breath of newborn shapes lifelong immunological milieu of lungs

The lung is an important interface between the body and the outside environment: with each breath, a surface of roughly 100 square meters exchanges oxygen for carbon dioxide. More than 10,000 liters of air pass adult lungs every day and with this come numerous viruses, bacteria and pollutants, which need to be prevented from entering the body.

22 Feb 2017

Drugs that target tissue stiffness could potentially prevent cancer metastasis

In order for cancer to spread, malignant cells must break away from a tumor and through the tough netting of extracellular matrix, or ECM, that surrounds it. To fit through the holes in this net, those cancerous cells must elongate into a torpedo-like shape.

22 Feb 2017

Researchers develop novel in vivo model for studying pancreatic cancer

Researchers at Okayama University report in the December 2016 issue of the American Journal of Cancer Research a novel in vivo model for the study of pancreatic ductal adenocarcinoma (PDAC) tumors.

21 Feb 2017

Targeting RNA repeats

RNA repeats are stretches of code in the body that incrementally repeat. For example, in the most common cause of adult-on-set muscular dystrophy a RNA has a repeat of r(CUG) and this three letter code can repeat thousands of times.

20 Feb 2017

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

17 Feb 2017

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

In a new study, researchers at The Scripps Research Institute have described how two important molecules in the brain work together to trigger intense anxiety.

13 Feb 2017

Study shows how errors in specific gene can cause growth defects linked to dwarfism

A new study shows how errors in a specific gene can cause growth defects associated with a rare type of dwarfism.

13 Feb 2017

Researchers identify link between neuronal proteins and frontotemporal lobar degeneration

Frontotemporal lobar degeneration is a type of dementia characterized by personality changes, language dysfunction, and abnormal behavior. It has an earlier onset than Alzheimer's disease, and is associated with a buildup of the tau protein in affected nerve cells (neurons).

13 Feb 2017

Study explores links between genetic susceptibility and heterogeneous phenotypes of lymphedema

Each year, about 1.38 million women worldwide are diagnosed with breast cancer. Advances in diagnosis and treatment have facilitated a 90-percent, five-year survival rate, among those treated.

9 Feb 2017

Study shows how organism's phenotypic diversity co-evolves with cooperation to protect from invaders

A new model exploring how evolutionary dynamics work in natural selection has found that phenotypic diversity, or an organism's observable traits, co-evolves with contingent cooperation when organisms with like traits work together to protect themselves from outsiders, according to a Dartmouth-led study published in PLOS Computational Biology.

3 Feb 2017

Single Molecule Detection of Proteins in Single Cells

We developed this technology almost 10 years ago. It was developed after a key experiment was carried out by David Rissin, who was a PhD candidate in my laboratory at the time.

From Pittcon 3 Feb 2017

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

Pulmospheres, three dimensional multicellular spheroids composed of lung cells from individual patients, were shown to be effective in predicting the efficacy of medications for idiopathic pulmonary fibrosis, according to findings from University of Alabama at Birmingham scientists presented today in JCI Insight, a journal of the American Society for Clinical Investigation.

27 Jan 2017

Researchers show how social environment can have large impact on weight and health in mice

The genetics of nearby mice can have a large impact on one animal's weight and health, according to a report by Amelie Baud and Oliver Stegle of the European Bioinformatics Institute (EMBL - EBI) in Hinxton, United Kingdom, published on January 25th, 2017 in PLOS Genetics.

25 Jan 2017

Reducing cocaine use can potentially reverse coronary atherosclerosis

People who use cocaine regularly are at high risk of coronary artery disease. A study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine, reports that stopping or reducing cocaine use can potentially reverse the process of coronary atherosclerosis. The journal is published by Wolters Kluwer.

12 Jan 2017

Phenotype News and Research

Machine learning helps researchers uncover cellular control networks

Researchers develop new software tool to provide fast, accurate quantification of gene expression

Linking RNA to autoimmune diseases

Study describes method to engineer brown adipose tissue from white fat-derived stem cells

Immune system defect makes Addison’s patients prone to respiratory infections

New investigational drug may help combat antibiotic-resistant global health threat

First breath of newborn shapes lifelong immunological milieu of lungs

Drugs that target tissue stiffness could potentially prevent cancer metastasis

Researchers develop novel in vivo model for studying pancreatic cancer

Targeting RNA repeats

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

Study shows how errors in specific gene can cause growth defects linked to dwarfism

Researchers identify link between neuronal proteins and frontotemporal lobar degeneration

Study explores links between genetic susceptibility and heterogeneous phenotypes of lymphedema

Study shows how organism's phenotypic diversity co-evolves with cooperation to protect from invaders

Single Molecule Detection of Proteins in Single Cells

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

Researchers show how social environment can have large impact on weight and health in mice

Reducing cocaine use can potentially reverse coronary atherosclerosis

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

Latest News