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Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment.

10 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Study suggests potential therapeutic targets for COVID-19-related neurological pathologies

In a recent study published in the journal Molecular & Cellular Proteomics, researchers analyzed the proteins in cerebrospinal fluid (CSF) samples obtained from African green monkeys and rhesus macaques infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 to understand the neurological manifestations of coronavirus disease 2019 (COVID-19).

9 Apr 2023

Study reveals SARS-CoV-2 on hands and frequently-touched surfaces as key predictors of household transmission

A study investigating risk factors and vectors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission reveals that the presence of the virus on the hands of primary and secondary cases and on frequently-touched surfaces is associated with transmission risk. The study is published in the journal THE LANCET Microbe.

9 Apr 2023

DPE analysis may help improve the diagnosis and management of colorectal cancer

A new editorial paper was published in Oncoscience (Volume 10) on March 23, 2023, entitled, "New method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing."

7 Apr 2023

New finding in roundworms upends classical thinking about animal cell differentiation

Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

7 Apr 2023

Regulatory T cell populations descend from two different origins, finds study

A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP).

7 Apr 2023

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder - a condition in which the body's immune system attacks healthy tissues.

7 Apr 2023

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

A team led by researchers at Weill Cornell Medicine, the University of Wisconsin-Madison; Scripps Research and the University of Chicago has identified an antibody that appears to block infection by all dominant variants of the virus that causes COVID-19, including Omicron, the most recent.

7 Apr 2023

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

Leveraging cell self-destruction to treat glioblastoma tumors

Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies.

7 Apr 2023

Is preserved vegetable consumption associated with mortality?

Researchers evaluated the association between the consumption of preserved vegetables and mortality.

7 Apr 2023

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Proteins are the key players for virtually all molecular processes within the cell. To fulfil their diverse functions, they have to interact with other proteins.

7 Apr 2023

Study explores the association between gut microbiome dysbiosis and uveitis

Researchers provide an overview of existing research on the correlation between uveitis and gut dysbiosis.

7 Apr 2023

Mediterranean diet and the modulation of mitochondrial function

Researchers reviewed the current knowledge related to the Mediterranean diet (MedDiet) and the role of mitochondria concerning health outcomes.

7 Apr 2023

UW researchers engineer stem cells that do not generate dangerous arrhythmias

Researchers at the University of Washington School of Medicine in Seattle have engineered stem cells that do not generate dangerous arrhythmias, a complication that has to date thwarted efforts to develop stem-cell therapies for injured hearts.

7 Apr 2023

Chemists discover novel, highly effective anticancer agents with tridimensional structures

A research team co-led by chemists from City University of Hong Kong recently discovered novel, highly effective anticancer agents with tridimensional structures, which have high anticancer activity, low toxicity and the ability to overcome drug resistance in cancer cells.

7 Apr 2023

Ingenious device enables construction of complex 3D organoids in a simpler way

A team led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques.

7 Apr 2023

Broccoli intake protects the small intestine lining, inhibits development of disease

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

6 Apr 2023

Creation of embryo-like structures from monkey embryonic stem cells for the first time

Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study.

6 Apr 2023

Cell News and Research

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Study suggests potential therapeutic targets for COVID-19-related neurological pathologies

Study reveals SARS-CoV-2 on hands and frequently-touched surfaces as key predictors of household transmission

DPE analysis may help improve the diagnosis and management of colorectal cancer

New finding in roundworms upends classical thinking about animal cell differentiation

Regulatory T cell populations descend from two different origins, finds study

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Newly discovered antibody appears to block infection by all dominant variants of SARS-CoV-2 virus

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Leveraging cell self-destruction to treat glioblastoma tumors

Is preserved vegetable consumption associated with mortality?

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Study explores the association between gut microbiome dysbiosis and uveitis

Mediterranean diet and the modulation of mitochondrial function

UW researchers engineer stem cells that do not generate dangerous arrhythmias

Chemists discover novel, highly effective anticancer agents with tridimensional structures

Ingenious device enables construction of complex 3D organoids in a simpler way

Broccoli intake protects the small intestine lining, inhibits development of disease

Creation of embryo-like structures from monkey embryonic stem cells for the first time

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