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Older adults living in disadvantaged neighborhoods more likely to experience post-op delirium

Where you live can increase your risk for experiencing delirium after surgery. So said a study that showed older adults who live in the most disadvantaged neighborhoods are two times more likely to experience delirium after surgery than their counterparts from more affluent communities.

31 Aug 2020

T cell epitopes from recovered COVID-19 patients identified for vaccine

A new study by researchers at The Hong Kong University of Science and Technology and published on the preprint server bioRxiv in August 2020 collates the available database of SARS-CoV-2 T cell epitopes gathered from 8 studies of COVID-19 patients who recovered. This could serve as a launchpad to fill in knowledge gaps regarding the immunological aspects of this disease, and drive towards an effective T cell vaccine.

31 Aug 2020

Patients with newly diagnosed atrial fibrillation benefit from early rhythm control therapy

Patients with newly diagnosed atrial fibrillation benefit from early rhythm control therapy, according to results of the EAST-AFNET 4 trial presented in a Hot Line session today at ESC Congress 2020.

31 Aug 2020

IL-6 signaling blockade can alleviate severe COVID-19

A team of researchers led by Osaka University find an overlap in the pathogenesis of cytokine release syndrome and COVID-19, and show that the symptoms of both can be alleviated by IL-6 signaling blockade

31 Aug 2020

ESC publishes treatment guidelines for non-ST-segment elevation acute coronary syndrome

ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

31 Aug 2020

Cat antiviral that inhibits SARS-CoV-2 fast-tracked for human clinical trials

Now, a team of researchers at the University of Alberta in Canada has identified viral inhibitors that they claim are potential candidates as a treatment for COVID-19. The team is set to launch clinical trials of the drug that is used as a treatment for a type of coronavirus in cats.

31 Aug 2020

Serum protein shows therapeutic value against severe COVID-19-like features in mouse model

A new study published on the preprint server bioRxiv* in August 2020 reports the disease-mitigating effects of a serum protein called serum amyloid P (SAP) in mice exposed to a peptide that mimics the clinical signs of severe COVID-19 in humans.

30 Aug 2020

New lipid derivatives of Remdesivir have higher anti-coronavirus activity

In a fascinating new preprint paper published on bioRxiv* in August 2020, the researchers report “the synthesis and antiviral evaluation of three novel lipophilic prodrugs of RVn-monophosphate that are substantially more active than Remdesivir in cells infected with SARS-CoV-2.” These could be of immense use in treating COVID-19 patients early and helping to end transmission.

30 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

However, the nucleocapsid (N) protein is also extremely abundant and, therefore, a useful target for both vaccine and diagnostic test development. A new study published on the preprint server bioRxiv in August 2020 reveals the structure of this protein, a valuable step in using it for these purposes.

30 Aug 2020

Severe and fatal COVID-19 is rare in children

Now, a new study by researchers at the Universities of Edinburgh and Liverpool, Imperial College London, and the Royal Hospital for Children, Glasgow in the United Kingdom has shown that children and teenagers are less likely than adults to develop severe COVID-19 or die from the disease.

30 Aug 2020

Evidence of SARS-CoV-2 spreading in an airplane toilet

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease (COVID-19), is still actively spreading like wildfire, with nearly 300,000 new infections reported daily across the globe. Early on in the outbreak in China, scientists said that the virus could spread through respiratory droplets, when a person coughs, sneezes, or speaks.

30 Aug 2020

FDA grants Abbott's COVID-19 rapid antigen test emergency-use authorization

Now, the U.S. Food and Drug Administration has granted emergency-use authorization to Abbott Laboratories for a $5 rapid-response COVID-19 antigen test, called BinaxNOW COVID-19 Ag Card, which is roughly the size of a credit card.

27 Aug 2020

Blood thinners help reduce the risk of COVID-19 deaths, study finds

Now, a new study by a team of researchers at the Mount Sinai Health System in New York has shown that blood thinners may reduce the risk of death by up to 50 percent among severely ill hospitalized COVID-19 patients.

27 Aug 2020

New low-cost COVID-19 test quickly delivers accurate results

A new low-cost diagnostic test for coronavirus disease 2019 (COVID-19) quickly delivers accurate results without the need for sophisticated equipment, according to a study published August 27 2020 in the open-access journal PLOS Pathogens by Teng Xu of the Vision Medicals Center for Infectious Diseases, Tieying Hou of the Guangdong Academy of Medical Sciences, Bing Gu of the Affiliated Hospital of Xuzhou Medical University, Jianwei Wang of the Chinese Academy of Medical Sciences and Peking Union Medical College, and colleagues.

27 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

Study identifies three clinical course variations in patients with acute decompensated cirrhosis

When the body can no longer compensate the gradual failure of the liver caused by liver cirrhosis, there is a high risk of acute decompensated liver cirrhosis.

27 Aug 2020

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

Researchers in Milan, Italy, have identified the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the heart tissue of deceased coronavirus disease 2019 (COVID-19) patients who had died from respiratory failure, without showing any signs of cardiac involvement.

27 Aug 2020

Two viral gene targets needed in SARS-CoV-2 detection by PCR, say researchers

Researchers at the Chan Zuckerberg Biohub, San Francisco, and collaborators have warned against only targeting one viral gene when carrying out reverse transcriptase-polymerase chain reaction (RT-PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

27 Aug 2020

First lethal mouse model of SARS-CoV-2 developed

Army scientists have developed the first lethal mouse model of SARS-CoV-2, the virus that causes COVID-19, using mice that were genetically engineered to express the human ACE2 gene--a key mechanism by which the virus enters human cells.

27 Aug 2020