RNA Sequencing News and Research

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Researchers discover elusive cell type in fish sensory organs

One of the evolutionary disadvantages for mammals, relative to other vertebrates like fish and chickens, is the inability to regenerate sensory hair cells.

26 Apr 2021

Recreating early embryos using stem cells

In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos.

23 Apr 2021

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice.

22 Apr 2021

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

A small proportion of women who receive anti-estrogen treatment after breast cancer surgery have worse outcomes. This is associated with mutations in the estrogen receptor gene, according to a study from Lund University now published in JNCI Cancer Spectrum.

22 Apr 2021

Researchers study ways to improve pediatric heart transplant outcomes

Scientific research teams in California and Texas have been awarded nearly $1.4 million in grants to study ways to improve pediatric heart transplant outcomes.

21 Apr 2021

Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer's disease, and advance disease.

19 Apr 2021

Study reveals new genes that program stem cells to make dendritic cells

Using a new single-cell technique, WEHI researchers have uncovered a way to understand the programming behind how stem cells make particular cell types.

16 Apr 2021

Researchers uncover a new source of energy expending brown fat cells

A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity.

12 Apr 2021

Research may lead to a significant breakthrough in the battle against deadly brain tumors

Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer.

12 Apr 2021

COVID19's cytokine storm ushers in a local complement storm in the lungs

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces the complement system as a dangerous weapon for viral infection.

12 Apr 2021

Dramatic cuts to UK foreign aid budgets undermine global research partnerships

Dramatic cuts to UK foreign aid budgets have left the future of hundreds of research projects in developing countries hanging in the balance and trusted partnerships severely undermined, say leading scientists.

7 Apr 2021

Researchers use single-cell RNA sequencing technologies to track cellular development in leaves

While developmental biologists have long researched this fundamental question, Stanford University biologist and HHMI investigator Dominique Bergmann's recent work on the plant Arabidopsis thaliana has uncovered surprising answers.

5 Apr 2021

New RNA-sequencing method can help detect numerous modified small RNAs

A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable.

5 Apr 2021

Study opens door to new approaches for preventing the development of metabolic diseases

The protein Asc-1 regulates whether fat-burning beige or fat-storing white adipocytes are formed, which can have an impact on the development of metabolic diseases.

31 Mar 2021

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat, since its causes have not yet been adequately researched.

30 Mar 2021

Scientists use specially designed gold nanoparticles to 'seek out' bone stem cells

Researchers at the University of Southampton have developed a new way of using nanomaterials to identify and enrich skeletal stem cells - a discovery which could eventually lead to new treatments for major bone fractures and the repair of lost or damaged bone.

29 Mar 2021

Researchers examine circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

New research published in Briefings in Bioinformaticsm has identified thousands of circRNAs in Betacoronaviruses, including MERS-CoV, SARS-CoV-1, and SARS-CoV-2, from the RNA-sequencing data of viral infections. These coronaviruses have a similar genomic structure with a diverse circRNA coding ability. Researchers have also systematically characterized circRNAs in coronaviruses, with regard to their size, sequence feature, expressions, genome, location preference, and functions. This opens the door to further explore and understand the mode of action of individual circRNAs in coronaviruses.

29 Mar 2021

New "machine learning" method helps analyze large amounts of biological data

Studying genetic material on a cellular level, such as single-cell RNA-sequencing, can provide scientists with a detailed, high-resolution view of biological processes at work.

26 Mar 2021

Scientists reveal salivary gland cells as sites of COVID-19 infection

Scientists have shown that SARS-CoV-2, the virus that causes COVID-19, can infect specific cells in the salivary gland in the mouth.

25 Mar 2021

RNA Sequencing News and Research

Researchers discover elusive cell type in fish sensory organs

Recreating early embryos using stem cells

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

Researchers study ways to improve pediatric heart transplant outcomes

Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

Study reveals new genes that program stem cells to make dendritic cells

Researchers uncover a new source of energy expending brown fat cells

Research may lead to a significant breakthrough in the battle against deadly brain tumors

COVID19's cytokine storm ushers in a local complement storm in the lungs

Dramatic cuts to UK foreign aid budgets undermine global research partnerships

Researchers use single-cell RNA sequencing technologies to track cellular development in leaves

New RNA-sequencing method can help detect numerous modified small RNAs

Study opens door to new approaches for preventing the development of metabolic diseases

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Scientists use specially designed gold nanoparticles to 'seek out' bone stem cells

Researchers examine circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

New "machine learning" method helps analyze large amounts of biological data

Scientists reveal salivary gland cells as sites of COVID-19 infection

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