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New device could keep implantable "living pharmacy" cells alive for months

In 2021, a Northwestern University-led research team received a Defense Advanced Research Projects Agency (DARPA) contract worth up to $33 million to develop an implantable "living pharmacy" to control the human body's sleep/wake cycles.

9 Nov 2023

Cannabis and derivatives show promise in reducing weight and waist circumference, with nuanced effects on body fat

The study in the International Journal of Obesity reports that cannabis and its derivatives may influence weight and waist circumference, with different effects on body fat, suggesting potential as a therapeutic aid in obesity management.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Open wounds, whether caused by accidents or from medical procedures like surgery, require proper management to speed up healing and prevent infections.

6 Nov 2023

Marijuana-like compound shows promise as new treatment for skin lupus

A marijuana-like compound holds out promise as a new treatment for a severe autoimmune skin disease called skin lupus, according to a study published recently by a multicenter team including researchers at the George Washington University.

2 Nov 2023

Seaweed symbionts reveal treasure trove of potential drug compounds

Marine macroalgae-associated Bacillota reveal a trove of bioactive compounds with potential pharmacological benefits, from antibacterial to anticancer properties. This comprehensive review illuminates the promising yet underexplored therapeutic applications of these marine microorganisms.

1 Nov 2023

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments.

31 Oct 2023

How next-gen sequencing is changing antibody drug discovery

New study outlines how next-generation sequencing (NGS) and machine-learning methods can revolutionize antibody discovery, particularly against SARS-CoV-2. The research demonstrates that NGS provides greater epitopic and paratopic diversity, enabling more effective identification and prioritization of therapeutic antibodies.

31 Oct 2023

AI may help identify potential gonorrhea vaccine proteins

Gonorrhea, a sexually transmitted bacterial infection that affects more than 80 million people worldwide every year, has become resistant to almost all known antibiotics.

31 Oct 2023

Study shows phages can promote mammalian cellular growth and survival

Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell.

26 Oct 2023

Fungi used to produce food products have potential probiotic effects on gut inflammation

Many fungus strains have been used and selected by the food industry for their capacities to ferment, produce flavors or produce heterologous molecules.

26 Oct 2023

In acute myocardial infarction patients, does adding a traditional Chinese medicine compound to standard treatments improve outcomes?

Researchers investigated whether Tongxinluo, a Chinese medicinal compound, could improve clinical outcomes among ST-segment elevation myocardial infarction patients.

26 Oct 2023

From Mount Everest to your liver: The alarming reach of 'forever chemicals' in our environment and health

Research paper provides a comprehensive review of per- and polyfluoroalkyl substances (PFAS), exploring their environmental prevalence, human exposure risks, and liver toxicity. The study highlights urgent gaps in PFAS research and calls for more studies to better understand these 'forever chemicals' and their impact on human health.

26 Oct 2023

Ketogenic diet boosts IVF success for women with PCOS, study reveals

A recent study in the journal "Nutrients" investigated the effects of dietary interventions, including the Mediterranean diet (MD) and a very low-calorie ketogenic diet (VLCKD), on overweight or obese women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF).

24 Oct 2023

Lactobacillus iners in tumors: Driving chemoradiation resistance via lactate-induced metabolic rewiring

Investigating tumor and gut microbiome traits that impact chemoradiation therapy in patients with cervical cancer.

24 Oct 2023

New insights into why obesity puts individuals at risk for severe influenza

The mechanisms underpinning severe cases of influenza among the obese population.

23 Oct 2023

Ketamine's long-lasting antidepressant effects unveiled in new study

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

22 Oct 2023

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

Researchers at The University of Texas MD Anderson Cancer Center have discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy, suggesting that lactic acid-producing bacteria present in various cancers may serve as novel therapeutic targets.

19 Oct 2023

in vitro News and Research

New device could keep implantable "living pharmacy" cells alive for months

Cannabis and derivatives show promise in reducing weight and waist circumference, with nuanced effects on body fat

New antifungal molecule shows promise in combatting fungal infections without toxicity

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Marijuana-like compound shows promise as new treatment for skin lupus

Seaweed symbionts reveal treasure trove of potential drug compounds

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

How next-gen sequencing is changing antibody drug discovery

AI may help identify potential gonorrhea vaccine proteins

Study shows phages can promote mammalian cellular growth and survival

Fungi used to produce food products have potential probiotic effects on gut inflammation

In acute myocardial infarction patients, does adding a traditional Chinese medicine compound to standard treatments improve outcomes?

From Mount Everest to your liver: The alarming reach of 'forever chemicals' in our environment and health

Ketogenic diet boosts IVF success for women with PCOS, study reveals

Lactobacillus iners in tumors: Driving chemoradiation resistance via lactate-induced metabolic rewiring

New insights into why obesity puts individuals at risk for severe influenza

Ketamine's long-lasting antidepressant effects unveiled in new study

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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