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Next generation antibiotic compounds that do not provoke bacterial resistance

Bacterial resistance to antibiotics is one of medicine's most vexing challenges.

15 Mar 2009

New approach to prevent bacterial infections from taking hold

Dr Quinn Parks and colleagues describe how they used enzymes against products of the body's own defence cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm which enables them to avoid both the body's immune mechanisms and antibiotics.

15 Mar 2009

Researchers look at genetic dynamics of inbreeding depression

Researchers have taken a first look at the broad genetic changes that accompany reproductive declines in inbred populations.

12 Mar 2009

Cells get two chances, not just one, to fix their mistakes

Cells have two chances to fix the same mistake in their protein-making process instead of just one - a so-called proofreading step - that had previously been identified, according to new research.

12 Mar 2009

Bioinformatics sheds light on evolutionary origin of Rickettsia virulence genes

Scientists from the Virginia Bioinformatics Institute (VBI) at Virginia Tech, the University of Maryland School of Medicine, and the University of Louisville have revealed that genes for a specific type of molecular secretion system in Rickettsia, a structure that is linked in many cases to virulence, have been conserved over many years of evolution.

11 Mar 2009

Space-grown bacteria help explain Salmonella illness

Salmonella bacteria research from two recent NASA space missions discovered key elements of the bacteria's disease-causing potential that hold promise for improving ways to fight food-borne infections on Earth.

11 Mar 2009

Protein structures reveal "big bang" of innovation in evolution

A new study of proteins, the molecular machines that drive all life, also sheds light on the history of living organisms.

11 Mar 2009

Researchers probe mechanisms of infection

A newly discovered receptor in a strain of Escherichia coli might help explain why people often get sicker when they're stressed.

10 Mar 2009

How chemicals present in cranberries prevent urinary tract infections

Chemicals present in cranberries - and not the acidity of cranberry juice, as previously thought - prevent infection-causing bacteria from attaching to the cells that line the urinary tract, as documented in a report published in Journal of Medicinal Food.

10 Mar 2009

How to avoid colon problems

Most adults would rather keep talk about colons behind the bathroom door.It's time to talk, says Kim Turgeon, MD, FACP, gastroenterologist in Internal Medicine at the University of Michigan Health System.

10 Mar 2009

Breakthrough improves effectiveness of tuberculosis vaccine

A breakthrough strategy to improve the effectiveness of the only tuberculosis vaccine approved for humans provided superior protection against the deadly disease in a pre-clinical test, report scientists at The University of Texas Health Science Center at Houston in Nature Medicine 's Advance Online Publication March 1.

8 Mar 2009

Synthetic biology extends anti-malaria drug artemisinin's effectiveness

In addition to providing a simple and much less expensive means of making artemisinin, the most powerful anti-malaria drug in use today, synthetic biology can also help to extend the effectiveness of this drug.

8 Mar 2009

Mobile phones belonging to hospital workers covered in bugs

Mobile phone handsets belonging to hospital workers are covered in bacteria including the 'superbug', MRSA (methicillin-resistant Staphylococcus aureus ).

5 Mar 2009

Scientists make a strain of E. coli glow under fluorescent light

A team of Michigan Technological University researchers led by Associate Professor of Chemistry Haiying Liu has discovered how to make a strain of E. coli glow under fluorescent light.

5 Mar 2009

Pharmacies offering no-cost antibiotics should promote responsible use, CDC says

CDC last week sent out letters to several chain pharmacies that offer no-cost prescription antibiotics to low-income consumers urging them to promote responsible use of antibiotics, the New York Times reports.

5 Mar 2009

Experimental microbicide containing natural compound provides protection in monkeys against simian version of HIV

An experimental microbicide containing a naturally occurring compound provides protection in monkeys against the simian version of HIV by diminishing immune responses to the virus, according to a study published Wednesday in the journal Nature, the Los Angeles Times reports.

5 Mar 2009

Immune reaction to metals in joint replacement devices leads to early failure

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

4 Mar 2009

Tuberculosis breakthrough could lead to stronger vaccine

3 Mar 2009

Insecticidal toxin useless without 'friendly' bacteria accomplices

The toxin produced by the bacterium Bacillus thuringiensis (Bt) is a popular insecticide used to control pest moths and butterflies, and in some GM pest-proof crops.

3 Mar 2009

Discovery of gene that modifies severity of cystic fibrosis lung disease

Researchers at Wake Forest University Baptist Medical Center, and colleagues, have identified a gene that modifies the severity of lung disease in people with cystic fibrosis, a lethal genetic condition. The findings open the door to possible new targets for treatment, researchers say.

3 Mar 2009