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Researchers identify therapies for multiple myeloma patients whose cancer relapses after CAR-T

Mount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an immunotherapy known as CAR-T only to find their cancer coming back afterwards.

4 Nov 2022

Blood pressure drug associated with lower risk of Alzheimer's disease in Black patients

Considering how patients from different ethnic groups respond to the same drug could be crucial to finding new Alzheimer's disease treatments – a disorder the Alzheimer's Association previously deemed a "silent epidemic" among Black adults.

4 Nov 2022

Charles River Laboratories: New Center Expands Cell and Gene Therapy Capabilities

In this interview, Niall Dinwoodie, Executive Director for Gene Therapy for Charles River in Europe discusses the opening of their new HQ Plasmid Center of Excellence at Alderley Park.

From Charles Rivers Laboratories Cell and Gene Therapy 4 Nov 2022

H pylori eradication protects against aspirin-associated peptic ulcer bleeding

A new study, led by experts at the University of Nottingham found that the risk of stomach bleeding caused by using aspirin long-term, can be reduced with a short course of antibiotics, potentially improving the safety of aspirin when used to prevent heart attacks, strokes and possibly some cancers.

4 Nov 2022

Environmental toxicants contribute to obesity and metabolic disease

In a recent study published in the Current Opinion in Pharmacology journal, researchers assessed the impact of environmental toxicants and brown adipose tissue (BAT) on obesity and metabolic disorders.

4 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Circadian disruption induces weight gain through changes in gut microbiota

In a recent study published in the journal Molecular Metabolism, researchers investigated the impact of environmental and genetic disruptions of the circadian rhythms on the peripheral circadian clock synchronization and microbiome oscillations in the gastrointestinal tract.

3 Nov 2022

Study shows a rise in blood pressure during COVID-19

In a recent study published in the journal Hypertension, researchers examined blood pressure (BP) outcomes in individuals with hypertension during the coronavirus disease 2019 (COVID-19) pandemic.

3 Nov 2022

Weekly weight loss drug reduces BMI in teens

Researchers report that a weekly dose of semaglutide led to a significant BMI reduction in adolescents.

3 Nov 2022

Novel monoclonal antibodies NA8 and NE12 can neutralize most SARS-CoV-2 variants and Omicron subvariants

Researchers generated and characterized two monoclonal antibodies (NA8 and NE12) that target the receptor binding domain of the SARS-CoV-2 spike protein, and exhibit neutralizing activity against major SARS-CoV-2 variants of concern.

3 Nov 2022

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins.

3 Nov 2022

New test detects low levels of pathogenic amphiphilic endotoxins

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a fast and cost-effective method to test liquids for a ubiquitous family of chemical compounds known as amphiphiles, which are used to detect diseases such as early-stage tuberculosis and cancer as well as to detect toxins in drugs, food, medical devices and water supplies.

3 Nov 2022

Novel platform allowing universal off-the-shelf T and NK cell access shows potential for immunotherapies

Recent advances in immunotherapy for cancer have stimulated a plethora of studies aimed at developing T cells (white blood cells) and Natural Killer (NK) cells (immune cells with enzymes that can kill tumor cells or cells infected with a virus) in-vitro from pluripotent stem cells - cells that are able to self-renew by dividing and developing into the three primary groups of cells that make up a human body.

3 Nov 2022

Blood clotting protein found to play a new role in repairing damaged blood vessels

Research by RCSI University of Medicine and Health Sciences has discovered a new role for the blood clotting protein, von Willebrand Factor (VWF), that could lead to the development of new treatments for patients with inflammatory and blood clotting disorders.

3 Nov 2022

What is the correlation between specific COVID-19 clinical characteristics and anti-SARS-CoV-2 antibody titers?

Researchers investigated the associations between clinical characteristics of coronavirus disease 2019 (COVID-19) and immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 Nov 2022

Researchers develop point-of-care device to facilitate monitoring of hereditary and hepatic metabolic disorders

Ammonium is a biomarker used to diagnose a series of rare hereditary metabolic disorders, such as the primary disorders of the urea cycle and different organic acidemias, as well as other metabolic and environmental conditions affecting the liver's function, which can cause a secondary dysfunction of the urea cycle.

3 Nov 2022

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

A new study revealed that gut colonization by proteobacteria modulates cocaine neurobehavioral response in mice.

3 Nov 2022

Study determines the diagnostic utility of liver stiffness measurement

Even after chronic hepatitis C has been cured, portal hypertension remains the major factor driving the development of complications in advanced liver disease. In cooperation with researchers from Spain, a research team led by Georg Semmler and Mattias Mandorfer from the Division of Gastroenterology and Hepatology at MedUni Vienna's Department of Medicine III showed that the non-invasive tests explored in their earlier studies accurately estimate the probability of sequelae.

3 Nov 2022

New insights into the dynamic inner world of the human immune system

As researchers glean new insights into the dynamic inner world of the human immune system, it has become increasingly clear that mitochondria are critical regulators of how our bodies respond to disease.

3 Nov 2022

Scientists identify a broadly neutralizing antibody against all dominant SARS-CoV-2 variants

Researchers in the United States identified a broadly neutralizing antibody (S728-1157 bnAb) that targets the receptor-binding site (RBS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Nov 2022

Blood News and Research

Researchers identify therapies for multiple myeloma patients whose cancer relapses after CAR-T

Blood pressure drug associated with lower risk of Alzheimer's disease in Black patients

Charles River Laboratories: New Center Expands Cell and Gene Therapy Capabilities

H pylori eradication protects against aspirin-associated peptic ulcer bleeding

Environmental toxicants contribute to obesity and metabolic disease

Fermented dairy products can improve gut mucosal immunity

Circadian disruption induces weight gain through changes in gut microbiota

Study shows a rise in blood pressure during COVID-19

Weekly weight loss drug reduces BMI in teens

Novel monoclonal antibodies NA8 and NE12 can neutralize most SARS-CoV-2 variants and Omicron subvariants

Researchers provide insights on how to overcome resistance in cancer therapy

New test detects low levels of pathogenic amphiphilic endotoxins

Novel platform allowing universal off-the-shelf T and NK cell access shows potential for immunotherapies

Blood clotting protein found to play a new role in repairing damaged blood vessels

What is the correlation between specific COVID-19 clinical characteristics and anti-SARS-CoV-2 antibody titers?

Researchers develop point-of-care device to facilitate monitoring of hereditary and hepatic metabolic disorders

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

Study determines the diagnostic utility of liver stiffness measurement

New insights into the dynamic inner world of the human immune system

Scientists identify a broadly neutralizing antibody against all dominant SARS-CoV-2 variants

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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