Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

SU2C announces international team for fighting gastric cancer

Stand Up To Cancer announced today that an international team of experts will take a new approach to fighting the world's third-leading cause of cancer death -- stomach (or gastric) cancer.

28 Jan 2020

Human organ chips for better drug development

The process of developing new drugs is both difficult and costly. It is estimated that of all the drug candidates which start out on their testing journey, less than 14% actually make it to the clinical scene and receive approval by the US Food and Drug Administration (FDA).

27 Jan 2020

Daratumumab proves effective in patients with relapsed AL amyloidosis

There's a new treatment option available for patients with AL amyloidosis: daratumumab. Studied in a prospective clinical trial, only one of the two clinical trials of this agent in AL amyloidosis worldwide, researchers have found this anti-cancer drug to be well tolerated and effective in patients with relapsed AL amyloidosis when used with appropriate pre- and post-infusion medications.

27 Jan 2020

Scientists use human stem cells to make pain-killing neurons

Researchers at the University of Sydney have used human stem cells to make pain-killing neurons that provide lasting relief in mice, without side effects, in a single treatment.

23 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Research paves the way to improved treatment for complex blood disorders

Nearly 1.6 billion people worldwide suffer from anemia, and for the first time new research points to how resistance emerges to the drug dexamethasone used to treat the devastating inherited form of anemia known as Diamond Blackfan anemia.

22 Jan 2020

Discovery of potent immune cell that can destroy multiple types of cancer

The immune system is the body’s defense against harmful pathogens that may enter the body. Immune cells, such as white blood cells and macrophages work hand in hand to fight off disease-causing microorganisms, including cancer.

21 Jan 2020

Raman spectroscopy can be used to diagnose the state of thrombocytes in cardiovascular patients

A team of scientists from Immanuel Kant Baltic Federal University used Raman spectroscopy to study the thrombocytes of patients with cardiovascular diseases and compared their spectra with those of healthy people.

21 Jan 2020

Study demonstrates striking improvements in bone marrow transplants since mid-2000s

A bone marrow transplant can be a lifesaving treatment, but it can come with life-threatening risks.

20 Jan 2020

Liver mesenchymal stromal cells could be a better option for many therapeutic applications

Mesenchymal stromal cells from fat tissue and bone marrow are widely used in therapeutic trials for their anti-inflammatory qualities, but new Mayo Clinic research finds that liver cells may be of greater value.

20 Jan 2020

Estrogen plays a role in expansion of liver metastases in non-sex-specific cancers

It is known that the tumor microenvironment plays an important role in the progression of cancer. But could estrogen present in this microenvironment facilitate the growth of liver metastases in women affected by colon, pancreatic and lung cancers?

17 Jan 2020

Harmful genetic mutations in healthy donors' stem cells may create problems in AML patients

A stem cell transplant - also called a bone marrow transplant - is a common treatment for blood cancers, such as acute myeloid leukemia.

16 Jan 2020

Biomaterial-based vaccine has potential to completely eliminate AML cells

Acute myeloid leukemia (AML) is a deadly blood cancer that originates in the bone marrow and kills most of its victims within five years. Chemotherapy has been the standard AML treatment for over 40 years, and while it often causes the cancer to go into remission, it rarely completely eliminates the cancerous cells, which then lead to disease recurrence in nearly half of treated patients.

14 Jan 2020

Research suggests a new role for neurogenesis

The ability to create new neurons may exist as built-in protection for sensitive brain areas, according to research in mice recently published in JNeurosci.

From Society for Neuroscience 14 Jan 2020

Study provides insights into how viral infection can continue to affect immunity

The strength of the immune system in response to respiratory infections is constantly changing, depending on the history of previous, unrelated infections, according to new research from the Crick.

From The Francis Crick Institute 14 Jan 2020

Research adds definitive evidence about how the body's earliest immune cells are formed

One day the advance could lead to a patient's own skin cells being used to produce new cells for cancer immunotherapy or to test autoimmune disease interventions.

8 Jan 2020

New nanotech technique fights advanced-stage sepsis

Scientists have found a novel approach using nanotechnology that can fight late-stage sepsis.

8 Jan 2020

New medicine can revolutionize treatment of inflammatory diseases and cancer

A medicine is being developed at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) which controls the concentration of oxygen radicals in immune cells, and could revolutionise treatment of inflammatory diseases or even cancer.

7 Jan 2020

Temperature fluctuations could give early indications of graft-versus-host disease

By continuously monitoring the body temperature of mice that had undergone bone-marrow transplants, researchers were able to detect early warning signs of graft-versus-host disease - a dangerous, sometimes deadly response of the transplanted immune system - in a simple, non-invasive way.

6 Jan 2020