Genes News and Research

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New genomic sequencing approach could be first step toward blood tests for early cancer detection

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high-intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

5 Jun 2017

Testicular cancer survivors with low testosterone more likely to have chronic health problems

In a large study, 38% of 491 testicular cancer survivors had low testosterone levels, known as hypogonadism.

5 Jun 2017

New targeted oral therapy results in durable responses across many kinds of cancer

Scientists may have developed the first targeted, oral, tumor-type agnostic therapy - a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients.

5 Jun 2017

Combination therapy shows potential for effective treatment of RAS-mutant cancers

A study at The University of Texas MD Anderson Cancer Center has shown promise for effective treatment of therapy-resistant cancers caused by a mutation of the RAS gene found in many cancers.

2 Jun 2017

Genetic sequencing could help direct treatment for 72% of advanced cancer patients

A new analysis finds that nearly three-quarters of 500 patients with advanced cancer could be referred to a potential targeted treatment based on the results of a comprehensive analysis of their tumor's genetic landscape.

2 Jun 2017

Mouse model could improve understanding of human brown fat’s role in metabolic processes

When it gets cold around you, your body turns up the heat to maintain its normal temperature. The heat is produced by brown adipose tissue, or brown fat, which also plays a role in how the body uses glucose and fat.

2 Jun 2017

Olive oil component may help prevent cancer developing in the brain

A compound found in olive oil may help to prevent cancer developing in the brain, a study shows. Research into oleic acid -- the primary ingredient in olive oil -- has shown how it can help prevent cancer-causing genes from functioning in cells.

2 Jun 2017

Tumorigenesis may be induced from neighboring tissues, study suggests

Current view is that cancer development is initiated from cells that acquire initial DNA mutations. These in turn provoke additional defects, and ultimately the affected cells begin to proliferate in an uncontrolled manner to develop primary tumors.

2 Jun 2017

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

Researchers at the Novo Nordisk Foundation Center for Biosustainability in Denmark have developed a method of producing P450 enzymes - used by plants to defend against predators and microbes - in bacterial cell factories. The process could facilitate the production of large quantities of the enzymes, which are also involved in the biosynthesis of active ingredients of cancer drugs.

2 Jun 2017

Association found between the uptake of various elements during pregnancy and autism risk

According to a study published on June 1 in Nature Communications, differences in the uptake of multiple toxic and essential elements over the second and third trimesters and in the early postnatal periods of pregnancy are connected with the risk of developing autism spectrum disorders (ASDs).

2 Jun 2017

Scientists discover unexpected mechanism behind chronic nerve pain

It has long been assumed that chronic nerve pain is caused by hypersensitivity in the neurons that transmit pain.

1 Jun 2017

New study establishes link between prenatal stress and onset of eating disorders

Stress affects the body and can trigger illness -- from psychiatric disorders to heart disease. Humans are exposed to stress at different intensities throughout life -- as children, in adolescence, and in old age. But when is the impact of stress on our systems most powerful? Many researchers maintain that the critical effect occurs prenatally, inside the womb.

1 Jun 2017

Differences in uptake of toxins, nutritional elements during late pregnancy and early life linked to ASD risk

Using evidence found in baby teeth, researchers from The Senator Frank R. Lautenberg Environmental Health Sciences Laboratory and The Seaver Autism Center for Research and Treatment at Mount Sinai found that differences in the uptake of multiple toxic and essential elements over the second and third trimesters and early postnatal periods are associated with the risk of developing autism spectrum disorders (ASD), according to a study published June 1 in the journal Nature Communications.

1 Jun 2017

Scientists identify new gene that prompts muscle stem cells to fuse together

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

1 Jun 2017

Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

Understanding how memories are made, retrieved, and eventually fade over a lifetime is the stuff of poems and song. To medical researchers, solving the mysteries of memory is even more elusive.

1 Jun 2017

LimTox online software tool provides information on drug hepatotoxicity

The Biological Text Mining Unit presents in a recent Nucleic Acids Research paper the LimTox online software tool developed at the Spanish National Cancer Research Centre.

1 Jun 2017

Study reveals key role of gut microbiota in treatment with classic diabetes medication

A clearer picture of how the classic diabetes medication metformin works has emerged. A recent study at Sahlgrenska Academy and University of Girona indicates that the clinical effect - control of blood glucose - is achieved through modulation of the gut microbiota.

1 Jun 2017

Genes News and Research

New genomic sequencing approach could be first step toward blood tests for early cancer detection

Testicular cancer survivors with low testosterone more likely to have chronic health problems

New targeted oral therapy results in durable responses across many kinds of cancer

Combination therapy shows potential for effective treatment of RAS-mutant cancers

Genetic sequencing could help direct treatment for 72% of advanced cancer patients

Mouse model could improve understanding of human brown fat’s role in metabolic processes

Olive oil component may help prevent cancer developing in the brain

Tumorigenesis may be induced from neighboring tissues, study suggests

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

Association found between the uptake of various elements during pregnancy and autism risk

Scientists discover unexpected mechanism behind chronic nerve pain

New study establishes link between prenatal stress and onset of eating disorders

Differences in uptake of toxins, nutritional elements during late pregnancy and early life linked to ASD risk

Scientists identify new gene that prompts muscle stem cells to fuse together

Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

LimTox online software tool provides information on drug hepatotoxicity

Study reveals key role of gut microbiota in treatment with classic diabetes medication

Micropollutants exert stress on aquatic ecosystems

Scientists identify 100 genes that provide new entry points into understanding human memory

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

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