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New research uncovers role of mysterious molecule in skin cancer

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma.

3 May 2017

Lost function of genes impairs development of motor skills in maturing mice

Scientists report in Neuron the lost function of two genes prevents infant laboratory mice from developing motor skills as they mature into adults. Researchers also suggest in their study that people with certain motor development disabilities be tested to see if they have mutant forms of the same genes.

3 May 2017

Scientists grow and purify earliest lung progenitors from human stem cells

Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells. But in a matter of months, the cells get organized. They gather together, branch and bud, some forming airways and others alveoli, the delicate sacs where our bodies exchange oxygen for carbon dioxide.

3 May 2017

MicroRNA-210 stabilizes deposits in carotid artery to prevent stroke risk

The molecule microRNA-210 stabilizes deposits in the carotid artery and can thus prevent them from tearing, and prevent dangerous blood clots from forming.

3 May 2017

Phthalate exposure linked to increased risk of allergies among children

Phthalates, which are used as plasticizers in plastics, can considerably increase the risk of allergies among children.

3 May 2017

IU researchers develop new method to grow inner ear tissue from human stem cells

Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells - PhDa finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.

3 May 2017

Researchers identify key player in initiation and progression of melanoma

Identification and functional validation of proteins involved in tumorigenesis are essential steps toward advancing cancer precision medicine. In The Journal of Clinical Investigation researchers from VIB, KU Leuven together with colleagues from INSERM now report the important role for FES in the initiation and progression of melanoma, a malignant type of skin cancer, that is notoriously quick to metastasize and that responds poorly to existing cancer treatments.

3 May 2017

Study suggests how existing and emerging immunotherapy treatments could be successful for sarcomas

Sarcomas- cancers of the connective tissues like muscles, joints, fat and bone - come in dozens of subtypes. Clinical trial results have been mixed when treating these diverse tumors with immunotherapy, a targeted therapeutic strategy that has success in other cancers.

3 May 2017

Specific genetic changes in the placenta of women may serve as biomarker to predict newborn health

UCLA scientists have discovered specific genetic changes in the placentas of women who gave birth to growth-restricted infants. These changes appear to sabotage the ability of the placenta to grow blood vessels and adequately nourish the fetus, interfering with the infant's growth in the womb.

3 May 2017

Prenatal cocaine exposure linked to increased risk of drug use among teens

While the crack cocaine epidemic peaked in the late 1980's, its effects are still causing harm to an estimated 3 million teenagers and young adults exposed to the stimulant in the womb.

3 May 2017

Myriad and Clovis ink deal on FDA-approved BRACAnalysis CDx test to identify patients with germline BRCA mutations for rucaparib treatment

Myriad Genetics, Inc. and Clovis Oncology, Inc. have announced a companion diagnostic collaboration to support a post-marketing regulatory commitment related to Clovis’ PARP inhibitor, Rubraca. Financial terms of the deal were not disclosed.

3 May 2017

Discovery of protein that causes liver disease brings hope for new treatments

In a world-first discovery, scientists at Sydney’s Westmead Institute for Medical Research have identified a protein that causes liver fibrosis (scarring), paving the way for new treatments for liver disease to be developed.

3 May 2017

Researchers develop fruit fly-based model to improve understanding of polycystic kidney disease

According to PKD International, 12.5 million people are affected by polycystic kidney disease. There is no known cure. But that may one day change, thanks in part to new research by a Concordia biology researcher.

2 May 2017

Study sets stage for potential stool-based test to detect advanced liver fibrosis

Nonalcoholic fatty liver disease (NAFLD) - a condition that can lead to liver cirrhosis and cancer - isn't typically detected until it's well advanced. Even then, diagnosis requires an invasive liver biopsy.

2 May 2017

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

The formation of a human embryo starts with the fertilization of the oocyte by the sperm cell. This yields the zygote, the primordial cell that carries one copy each of the maternal and paternal genomes.

2 May 2017

Researchers create new tool that reveals insights into cellular development

Researchers at Columbia University Medical Center have created a new tool to describe the many possible ways in which a cell may develop. Rooted in the mathematical field of topology, the tool provides a roadmap that offers detailed insight into how stem cells give rise to specialized cells.

2 May 2017

Researchers uncover molecule that may explain smoking-CHD connection

Cigarette smoking accounts for about one-fifth of cases of coronary heart disease, one of the leading causes of death worldwide, but precisely how smoking leads to CHD has long been unclear.

2 May 2017

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

Penn study sheds new light on mysterious powers of spider silk genes

They can be stronger than steel at a mere fraction of weight, and also can be tougher and more flexible. Spider silks also tend not to provoke the human immune system. Some even inhibit bacteria and fungi, making them potentially ideal for surgery and medical device applications.

2 May 2017

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

A novel gene therapy using CRISPR genome editing technology effectively targets cancer-causing "fusion genes" and improves survival in mouse models of aggressive liver and prostate cancers, University of Pittsburgh School of Medicine researchers report in a study published online today in Nature Biotechnology.

2 May 2017

Genes News and Research

New research uncovers role of mysterious molecule in skin cancer

Lost function of genes impairs development of motor skills in maturing mice

Scientists grow and purify earliest lung progenitors from human stem cells

MicroRNA-210 stabilizes deposits in carotid artery to prevent stroke risk

Phthalate exposure linked to increased risk of allergies among children

IU researchers develop new method to grow inner ear tissue from human stem cells

Researchers identify key player in initiation and progression of melanoma

Study suggests how existing and emerging immunotherapy treatments could be successful for sarcomas

Specific genetic changes in the placenta of women may serve as biomarker to predict newborn health

Prenatal cocaine exposure linked to increased risk of drug use among teens

Myriad and Clovis ink deal on FDA-approved BRACAnalysis CDx test to identify patients with germline BRCA mutations for rucaparib treatment

Discovery of protein that causes liver disease brings hope for new treatments

Researchers develop fruit fly-based model to improve understanding of polycystic kidney disease

Study sets stage for potential stool-based test to detect advanced liver fibrosis

EPFL researchers discover protein that kick-starts gene expression in nascent embryos

Researchers create new tool that reveals insights into cellular development

Researchers uncover molecule that may explain smoking-CHD connection

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Penn study sheds new light on mysterious powers of spider silk genes

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

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