Genes News and Research

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New study shows that gene editing technology can shut down HIV-1 replication in animals

A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, in new research published in print May 3 in the journal Molecular Therapy, scientists at the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that they can excise HIV DNA from the genomes of living animals to eliminate further infection.

2 May 2017

Scientists launch new virtual platform to aid global search for treatment of leukemia

Finding a cure for a rare type of blood cancer could be accelerated by a new virtual platform that allows researchers easy access to data from patient samples generated by laboratories around the world.

29 Apr 2017

Study describes new targets for precision treatment of meningiomas

Winner of the Integra Foundation Award, Mark W. Youngblood, presented his research, Clinical and Molecular Features of Genomic Subgroups in Meningioma, during the 2017 American Association of Neurological Surgeons Annual Scientific Meeting.

29 Apr 2017

Study sheds new light on evolutionary origin of the vertebrate brain

A study recently published in PLOS Biology provides information that substantially changes the prevailing idea about the brain formation process in vertebrates and sheds some light on how it might have evolved.

28 Apr 2017

Researchers discover new mechanism that causes chronic intestinal inflammation

Researchers at the University Medical Center of Johannes Gutenberg University Mainz and the German Research Center for Environmental Health, Helmholtz Zentrum München have discovered that too much of the oncogene Bcl-3 leads to chronic intestinal diseases.

28 Apr 2017

Gene critical for tumor progression also encourages growth of intestinal stem cells, study shows

A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers.

28 Apr 2017

Research on disc degeneration holds potential to help millions suffering from lower back pain

New research detailing the molecular mechanisms involved in the breakdown of the soft tissue discs of the spine has the potential to help millions suffering the debilitating back pain, and may provide opportunities for advanced, minimally invasive treatments.

28 Apr 2017

Scientists rewire mouse stem cells to fight inflammation caused by arthritis

Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions.

28 Apr 2017

Researchers discover new mechanism of epigenetic inheritance in fruit flies

Giacomo Cavalli's team at the Institute of Human Genetics (University of Montpellier / CNRS), in collaboration with the French National Institute for Agricultural Research, has demonstrated the existence of transgenerational epigenetic inheritance among Drosophila fruit flies.

27 Apr 2017

New technique dramatically accelerates search for new cancer treatments

A new technique developed at the University of Virginia School of Medicine will let a single cancer research lab do the work of dozens, dramatically accelerating the search for new treatments and cures.

26 Apr 2017

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson's disease.

26 Apr 2017

Researchers identify new antibiotic resistance gene in bacteria from dairy cows

Researchers of the University of Bern have identified a new antibiotic resistance gene in bacteria from dairy cows. This gene confers resistance to all beta-lactam antibiotics including the last generation of cephalosporins used against methicillin-resistant Staphylococcus aureus.

26 Apr 2017

Removing senescent cells from joints could reverse progression of osteoarthritis

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

26 Apr 2017

Obesity amplifies effects of three risk alleles linked to NAFLD

An international study based at UT Southwestern Medical Center revealed a striking genetic-environmental interaction: Obesity significantly amplifies the effects of three gene variants that increase risk of nonalcoholic fatty liver disease by different metabolic pathways.

26 Apr 2017

Study provides new insights on molecular mechanisms that impair muscle stem cells during aging

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a previously unrecognized step in stem cell-mediated muscle regeneration.

26 Apr 2017

Studies uncover link between immune system, brain structure and memory

The body's immune system performs essential functions, such as defending against bacteria and cancer cells. However, the human brain is separated from immune cells in the bloodstream by the so-called blood-brain barrier.

26 Apr 2017

Epigenetic changes detectable at birth linked to risk of obesity

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence. One of the main epigenetic modifications is DNA methylation, which plays a key role in embryonic development and the formation of different cell types, regulating when and where genes are switched on.

26 Apr 2017

Scientists use modern techniques to investigate how silver poisons pathogenic microbes

Silver and other metals have been used to fight infections since ancient times. Today, researchers are using sophisticated techniques such as the gene-editing platform Crispr-Cas9 to take a closer look at precisely how silver poisons pathogenic microbes - and when it fails.

26 Apr 2017

Vitamin A combined with high-fat diet may lead to increased risk for obesity and diabetes

Vitamin A is an essential nutrient that the human body needs to function properly. But new research presented today at the American Physiological Society annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high-fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

26 Apr 2017

Researchers discover genes linked to resilience against brain pathologies

The pathologies (damage) in the brain that stroke, Alzheimer's disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it.

26 Apr 2017

Genes News and Research

New study shows that gene editing technology can shut down HIV-1 replication in animals

Scientists launch new virtual platform to aid global search for treatment of leukemia

Study describes new targets for precision treatment of meningiomas

Study sheds new light on evolutionary origin of the vertebrate brain

Researchers discover new mechanism that causes chronic intestinal inflammation

Gene critical for tumor progression also encourages growth of intestinal stem cells, study shows

Research on disc degeneration holds potential to help millions suffering from lower back pain

Scientists rewire mouse stem cells to fight inflammation caused by arthritis

Researchers discover new mechanism of epigenetic inheritance in fruit flies

New technique dramatically accelerates search for new cancer treatments

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Researchers identify new antibiotic resistance gene in bacteria from dairy cows

Removing senescent cells from joints could reverse progression of osteoarthritis

Obesity amplifies effects of three risk alleles linked to NAFLD

Study provides new insights on molecular mechanisms that impair muscle stem cells during aging

Studies uncover link between immune system, brain structure and memory

Epigenetic changes detectable at birth linked to risk of obesity

Scientists use modern techniques to investigate how silver poisons pathogenic microbes

Vitamin A combined with high-fat diet may lead to increased risk for obesity and diabetes

Researchers discover genes linked to resilience against brain pathologies

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