Genes News and Research

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Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Imagine this scenario on a highway: A driver starts to make a sudden lane change but realizes his mistake and quickly veers back, too late. Other motorists have already reacted and, in some cases, collide. Meanwhile, the original motorist - the one who caused the problem - drives on.

25 Apr 2017

Neurobiologists use skin stem cells to generate new microglia

Using human skin cells, University of California, Irvine neurobiologists and their colleagues have created a method to generate one of the principle cell types of the brain called microglia, which play a key role in preserving the function of neural networks and responding to injury and disease.

25 Apr 2017

Scientists create new technique for studying how chlamydia interacts with immune system

Scientists at the Wellcome Trust Sanger Institute and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with the human immune system.

25 Apr 2017

Low levels of NPTX2 protein in the brain may lead to learning and memory loss in Alzheimer's disease

Working with human brain tissue samples and genetically engineered mice, Johns Hopkins Medicine researchers together with colleagues at the National Institutes of Health, the University of California San Diego Shiley-Marcos Alzheimer's Disease Research Center, Columbia University, and the Institute for Basic Research in Staten Island say that consequences of low levels of the protein NPTX2 in the brains of people with Alzheimer's disease (AD) may change the pattern of neural activity in ways that lead to the learning and memory loss that are hallmarks of the disease.

25 Apr 2017

Combination of genetics and experience gives each individual a unique sense of smell, study finds

Researchers from the Wellcome Trust Sanger Institute and their collaborators have shown that receptors in the noses of mice exposed to certain smells during life are different to genetically similar mice that lived without those smells.

25 Apr 2017

Study shows how gut microbiota may play role in effectiveness of chemotherapy drugs

The bacteria residing in your digestive tract, or your gut microbiota, may play an important role in your ability to respond to chemotherapy drugs in the clinic, according to a new study by scientists at the University of Massachusetts Medical School.

25 Apr 2017

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

Whole-exome DNA sequencing -- a technology that saves time and money by sequencing only protein-coding regions and not the entire genome -- may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.

24 Apr 2017

Researchers discover gene that may play role in restoring hearing after noise exposure

Researchers have discovered that a protein implicated in human longevity may also play a role in restoring hearing after noise exposure. The findings, where were published in the journal Scientific Reports, could one day provide researchers with new tools to prevent hearing loss.

24 Apr 2017

Synchronized voltage rhythms in SCN could play role in maintaining the body’s circadian clock

Cells in the brain's master circadian clock synchronize voltage rhythms despite asynchronous calcium rhythms, which might explain how a tissue-wide rhythm is maintained.

24 Apr 2017

$Women at highest genetic risk for fracture benefit most from hormone therapy, study finds$

Women at highest genetic risk for fracture benefit most from hormone therapy, study finds

Women at the highest genetic risk for fracture benefit the most from hormone therapy, according to a first-of-its-kind study led by researchers at the University at Buffalo.

24 Apr 2017

Brain genes influence our eating habits, study finds

Differences in the genetic make-up of our brains may account for the particular food preferences people have and their varying ability to stick to diets, according to new research.

24 Apr 2017

Study shows how brain genes influence food intake and dietary preferences

Have you ever wondered why you keep eating certain foods, even if you know they are not good for you? Gene variants that affect the way our brain works may be the reason, according to a new study. The new research could lead to new strategies to empower people to enjoy and stick to their optimal diets.

24 Apr 2017

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

An off-the-shelf dietary supplement available for pennies per dose demonstrated the ability to reverse cellular damage linked to specific genetic mutations in transgenic fruit flies, an experimental model of genetic mutation-induced renal cell injury that features striking similarities to humans, a Children's National Health System research team reports April 20 in Journal of the American Society of Nephrology.

21 Apr 2017

Positive CHMP opinion recognizes efficacy of Biogen’s SPINRAZA for treatment of spinal muscular atrophy

Biogen today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion recommending the granting of a marketing authorization for SPINRAZA to treat patients with spinal muscular atrophy (SMA).

21 Apr 2017

Latest advances in antibody delivery mediated by rAAV for treatment of chronic and infectious diseases

Monoclonal antibody-based therapies have revolutionized treatments of cancer and autoimmune diseases because of their specificity and limited toxicity.

21 Apr 2017

Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa.

21 Apr 2017

Light can be used to control cellular functions, optogenetics study shows

Light can be used as an accurate method to control gene expression, shows groundbreaking optogenetics study by University of Colorado, Duke University and University of Helsinki researchers.

21 Apr 2017

Researchers identify novel molecular mechanism involved in progression, metastasis of TNBC

University of Tsukuba-led researchers identified a novel molecular mechanism involved in progression and metastasis in the most aggressive form of breast cancer.

21 Apr 2017

Researchers identify how post-biotics lower blood glucose during obesity

You've heard of pre-biotics and pro-biotics, but now you'll be hearing a lot more about post-biotics. Researchers at McMaster University have begun to identify how post-biotics, or the by-products of bacteria, lower blood glucose and allow insulin to work better.

20 Apr 2017

Environmental 'memory' can be passed on in genes for many generations

Led by Dr Ben Lehner, group leader at the EMBL-CRG Systems Biology Unit and ICREA and AXA Professor, together with Dr Tanya Vavouri from the Josep Carreras Leukaemia Research Institute and the Institute for Health Science Research Germans Trias i Pujol, the researchers noticed that the impact of environmental change can be passed on in the genes for many generations while studying C. elegans worms carrying a transgene array - a long string of repeated copies of a gene for a fluorescent protein that had been added into the worm genome using genetic engineering techniques.

20 Apr 2017

Genes News and Research

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Neurobiologists use skin stem cells to generate new microglia

Scientists create new technique for studying how chlamydia interacts with immune system

Low levels of NPTX2 protein in the brain may lead to learning and memory loss in Alzheimer's disease

Combination of genetics and experience gives each individual a unique sense of smell, study finds

Study shows how gut microbiota may play role in effectiveness of chemotherapy drugs

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

Researchers discover gene that may play role in restoring hearing after noise exposure

Synchronized voltage rhythms in SCN could play role in maintaining the body’s circadian clock

Women at highest genetic risk for fracture benefit most from hormone therapy, study finds

Brain genes influence our eating habits, study finds

Study shows how brain genes influence food intake and dietary preferences

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

Positive CHMP opinion recognizes efficacy of Biogen’s SPINRAZA for treatment of spinal muscular atrophy

Latest advances in antibody delivery mediated by rAAV for treatment of chronic and infectious diseases

Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Light can be used to control cellular functions, optogenetics study shows

Researchers identify novel molecular mechanism involved in progression, metastasis of TNBC

Researchers identify how post-biotics lower blood glucose during obesity

Environmental 'memory' can be passed on in genes for many generations

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