Genes News and Research

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Researchers shed light on how immune cells weaken with age

Researchers from the European Bioinformatics Institute, University of Cambridge, the Wellcome Trust Sanger Institute and the Cancer Research UK–Cambridge Institute have shed light on a long-standing debate about why the immune system weakens with age.

3 Apr 2017

New gene-based blood tests can reliably detect previously unidentifiable forms of skin cancer

Genetic testing of tumor and blood fluid samples from people with and without one of the most aggressive forms of skin cancer has shown that two new blood tests can reliably detect previously unidentifiable forms of the disease.

3 Apr 2017

Study shows how early-life BPA exposure leads to NAFLD in adulthood

Exposure during infancy to the common plasticizer bisphenol A "hijacks" and reprograms genes in the liver of newborn rats, leading to nonalcoholic fatty liver disease in adulthood.

2 Apr 2017

University of Miami to begin clinical trial for testing DNA-based Zika vaccine

The University of Miami Miller School of Medicine will soon begin one of the nation's first full-scale Zika vaccine clinical trials testing the National Institutes of Health's (NIH) experimental DNA-based vaccine.

31 Mar 2017

Study provides new understanding of molecular mechanisms of HPV-induced tumors

The incidence of human papillomavirus (HPV)-associated (HPV+) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and is now more frequently diagnosed than uterine cervical cancer in the United States.

31 Mar 2017

Phase 2 clinical study of investigational Zika vaccine begins in the U.S., Central and South America

Vaccinations have begun in a multi-site Phase 2/2b clinical trial testing an experimental DNA vaccine designed to protect against disease caused by Zika infection.

31 Mar 2017

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

National Human Genome Research Institute researchers have identified new genes associated with the Erdheim-Chester disease and some possible new therapies. Findings on this ultra-rare disease, found in approximately 600 people in the world, were published in Blood Advances.

31 Mar 2017

Researchers discover how epigenetic lesion can lead to T-cell acute lymphoblastic leukemia

Researchers from the Epigenetics and Cancer Biology Program led by Dr. Manel Esteller at the Bellvitge Biomedical Research Institute have discovered how an epigenetic lesion can lead to T-cell acute lymphoblastic leukemia.

30 Mar 2017

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body.

30 Mar 2017

Single dose of siRNA molecule offers protection against heart attack and stroke in high-risk patients

Even a single dose of a specific ribonucleic acid molecule, known as a small interfering RNA (siRNA), offers patients at high risk of cardiovascular disease long-lasting protection against high LDL cholesterol - one of the main risk factors for heart attack and stroke.

30 Mar 2017

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

By engineering an on/off switch into a weakened form of HIV, University of Nebraska-Lincoln researchers have enhanced the safety and effectiveness of a potential vaccine for the virus that has killed approximately 35 million people during the past 35 years.

30 Mar 2017

Fruit flies genetically coded to take frequent naps have higher resistance to dangerous superbugs

A new University of Maryland study has found that fruit flies genetically coded to take frequent naps had the strongest resistance to both a fungal infection and to a bacteria that the World Health Organization says is one of the world's most dangerous superbugs for humans.

30 Mar 2017

Study shows inhibition of transgelin prevents vasculogenic mimicry in breast cancer

An article published in Experimental Biology and Medicine identifies a new signaling pathway involved in breast cancer cell growth. The study, led by Dr. Chan-Wha Kim, from the Department of Biotechnology at Korea University in Seoul, reports that inhibition of the actin-binding protein transgelin prevents vasculogenic mimicry (VM), a process that provides tumor cells with the nutrients required for growth.

29 Mar 2017

Researchers propose novel theory of how some cancers circumvent killing power of targeted therapies

Nearly 50 years into the "war" on cancer, doctors possess weapons that once would have seemed magical in their tumor-killing specificity.

29 Mar 2017

Research sheds new light on reasons behind recurrent aphthous stomatitis

A burning pain sensation - and treatments that do not work. This is what daily life is like for many of those who suffer from recurrent aphthous stomatitis. Research from the Sahlgrenska Academy now sheds new light on the reasons behind this condition found in the mouth.

29 Mar 2017

Scientists develop new tool to analyse single-cell RNA data in pre-malignant blood cancers

Wellcome Trust Sanger Institute scientists and their collaborators have developed a new analysis tool that was able to show, for the first time, which genes were expressed by individual cells in different genetic versions of a benign blood cancer.

29 Mar 2017

Researchers identify appetite-suppression mechanism in flies

Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding, according to a study publishing March 28 in the open access journal PLOS Biology by Walton Jones of the Korea Advanced Institute of Science and Technology in Daejeon, and colleagues.

29 Mar 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

TSRI researchers reveal how viruses incapacitate bacterial defense system

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas.

28 Mar 2017

Study identifies protein as potential therapeutic target for pancreatic cancer

A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five-year survival rate.

28 Mar 2017

Genes News and Research

Researchers shed light on how immune cells weaken with age

New gene-based blood tests can reliably detect previously unidentifiable forms of skin cancer

Study shows how early-life BPA exposure leads to NAFLD in adulthood

University of Miami to begin clinical trial for testing DNA-based Zika vaccine

Study provides new understanding of molecular mechanisms of HPV-induced tumors

Phase 2 clinical study of investigational Zika vaccine begins in the U.S., Central and South America

Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses

Researchers discover how epigenetic lesion can lead to T-cell acute lymphoblastic leukemia

Scientists uncover how tumor cells can switch disguises to spread easily around the body

Single dose of siRNA molecule offers protection against heart attack and stroke in high-risk patients

Researchers enhance safety, effectiveness of potential HIV vaccine using on/off genetic switch

Fruit flies genetically coded to take frequent naps have higher resistance to dangerous superbugs

Study shows inhibition of transgelin prevents vasculogenic mimicry in breast cancer

Researchers propose novel theory of how some cancers circumvent killing power of targeted therapies

Research sheds new light on reasons behind recurrent aphthous stomatitis

Scientists develop new tool to analyse single-cell RNA data in pre-malignant blood cancers

Researchers identify appetite-suppression mechanism in flies

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

TSRI researchers reveal how viruses incapacitate bacterial defense system

Study identifies protein as potential therapeutic target for pancreatic cancer

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