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Unexpected toxicity of pazopanib/pemetrexed in NSCLC halts study

A phase II study comparing first-line combination pazopanib/pemetrexed chemotherapy with the standard cisplatin/pemetrexed treatment in non-small-cell lung cancer was terminated early owing to an increased frequency of adverse events in the experimental arm.

17 Dec 2013

Atara Biotherapeutics secures $38.5M in initial closings under Series B financing

Atara Biotherapeutics, Inc., a drug development company with a focus on innovative therapies for patients with debilitating diseases, announced today that it has secured $38.5 million in initial closings under its Series B financing. In this round, investors Amgen Ventures, Celgene Corporation, and EcoR1 Capital, joined existing investors Alexandria Venture Investments, DAG Ventures, Domain Associates, and Kleiner Perkins Caufield & Byers.

17 Dec 2013

Doctors urge people to take advantage of Christmas gatherings to tackle ill-health

Doctors are encouraging people to take advantage of Christmas gatherings with relatives to discuss family medical histories to help tackle ill-health.

17 Dec 2013

New report shows death rates for lung cancer dropping at a faster pace

The Annual Report to the Nation on the Status of Cancer, covering the period 1975, showed death rates for lung cancer, which accounts for more than one in four cancer deaths, dropping at a faster pace than in previous years. The recent larger drop in lung cancer deaths is likely the result of decreased cigarette smoking prevalence over many years, and is now being reflected in mortality trends. The lung cancer death rate decline, as well as declines in colorectal, breast, and prostate cancer death rates, has also helped drive decreases in death rates for all cancers types combined, a trend that began about 20 years ago.

17 Dec 2013

Research finds link between opioid-sparing technique and reduced progression of prostate cancer

The methods used to anesthetize prostate cancer patients and control pain when their prostate glands are surgically removed for adenocarcinoma may affect their long-term cancer outcomes, a study led by Mayo Clinic has found. Opioids, painkillers commonly given during and after surgery, may suppress the immune system's ability to fight cancer cells.

17 Dec 2013

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has initiated a pilot Phase II study with ALN-TTRsc, a subcutaneously delivered RNAi therapeutic targeting the transthyretin gene in development for the treatment of TTR-mediated amyloidosis.

17 Dec 2013

WSU researchers discover how Nipah virus employs burglary-ring-like teamwork to infiltrate human cell

A team of scientists from Washington State University has discovered how one of the planet's most deadly known viruses employs burglary-ring-like teamwork to infiltrate the human cell.

17 Dec 2013

Increased risk of complications to mother, newborn associated with early-term deliveries

Enduring the last few weeks of pregnancy can be physically and emotionally challenging for some women. The aches and pains, the swelling of the limbs and the anxiety of when labor may start are part of the natural gestation process, but they also can seem unbearable.

17 Dec 2013

Secondary conditions can become deadly and affect how long HIV patients stay in hospital

A University of Arkansas researcher and her colleagues have found that secondary conditions and diseases that could become deadly significantly affect how long HIV patients stay in the hospital.

17 Dec 2013

Study: Health care costs increase in parallel with body mass measurements

Researchers at Duke Medicine are giving people another reason to lose weight in the new year: obesity-related illnesses are expensive. According to a study published in the journal Obesity, health care costs increase in parallel with body mass measurements, even beginning at a recommended healthy weight.

17 Dec 2013

BWH receives $140M grant from NIAID to support ongoing research led by AIDS Clinical Trial Group

The National Institute of Allergy and Infectious Diseases has awarded two seven-year grants to Brigham and Women's Hospital to fund the AIDS Clinical Trial Group Network.

16 Dec 2013

Researchers identify first biomarker that appears to be associated with duration of delirium

Researchers from the Regenstrief Institute and the Indiana University Center for Aging Research have identified the first biomarker that appears to be linked to the duration of delirium.

16 Dec 2013

Moderate consumption of alcohol can improve immune response to vaccination

It's the time of year when many of us celebrate the holidays with festive foods and drinks, including alcohol. No better time then to ask if it is true, as is widely held, that moderate consumption of alcohol is beneficial to health.

16 Dec 2013

Low vitamin D a consequence not a cause of ill health

Low vitamin D status is a marker of ill health rather than an underlying cause of disease, say the authors of a systematic review published in The Lancet Diabetes and Endocrinology.

16 Dec 2013

Research roundup: Long-term care use varies dramatically by state; health spending slowdown explained

In 2012, about 58,500 paid, regulated long-term care services providers served about 8 million people in the United States. Long-term care services were provided by 4,800 adult day services centers, 12,200 home health agencies, 3,700 hospices, 15,700 nursing homes, and 22,200 assisted living and similar residential care communities. Each day in 2012, there were 273,200 participants enrolled in adult day services centers, 1,383,700 residents in nursing homes, and 713,300 residents in residential care communities; in 2011, about 4,742,500 patients received services from home health agencies, and 1,244,500 patients received services from hospices. Provider sectors differed in ownership, and average size and supply varied by region (Harris-Kojetin et al., 12/12).

16 Dec 2013

Research: Released prisoners seven times more likely to commit suicide than general population

Research on the mortality of released prisoners is sparse and what research has been conducted has mainly focused on drug-related causes of death. This is a systematic review to investigate the risk of suicide in recently released prisoners.

16 Dec 2013

IOF Young Investigator Awards presented to five researchers at 4th Asia-Pacific Osteoporosis Meeting

Today, the International Osteoporosis Foundation recognized the outstanding work of five young researchers from China, Chinese Taipei, Hong Kong, Malaysia and Pakistan.

16 Dec 2013

$Early initiation of treatment after primary hip fracture helps reduce second fracture incidence, mortality$

Early initiation of treatment after primary hip fracture helps reduce second fracture incidence, mortality

Research presented today at the 4th Asia-Pacific Osteoporosis Meeting showed that second hip fractures are more deadly than first hip fractures. Based in Hong Kong, the study evaluated the overall incidence of a second hip fracture and subsequent mortality in 43,832 patients, aged 65 or above, with operatively treated first hip fracture during the years 2000-2011.

15 Dec 2013

NJHA's CEO wins FDR Visionary Award from March of Dimes

Betsy Ryan, Esq., president and CEO of the New Jersey Hospital Association, today was presented with the FDR Visionary Award from the March of Dimes, New Jersey Chapter.

15 Dec 2013

Analysis provides first empirical evidence on how shared savings ACO model affect quality of care

Approximately 10 percent of Medicare spending is for cancer care, and Medicare spending is nearly four times higher for beneficiaries with cancer than in those without the disease. Little is known about how to curb spending growth while maintaining or improving quality of care for these high-risk, high-cost patients.

14 Dec 2013

Mortality News and Research

Unexpected toxicity of pazopanib/pemetrexed in NSCLC halts study

Atara Biotherapeutics secures $38.5M in initial closings under Series B financing

Doctors urge people to take advantage of Christmas gatherings to tackle ill-health

New report shows death rates for lung cancer dropping at a faster pace

Research finds link between opioid-sparing technique and reduced progression of prostate cancer

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

WSU researchers discover how Nipah virus employs burglary-ring-like teamwork to infiltrate human cell

Increased risk of complications to mother, newborn associated with early-term deliveries

Secondary conditions can become deadly and affect how long HIV patients stay in hospital

Study: Health care costs increase in parallel with body mass measurements

BWH receives $140M grant from NIAID to support ongoing research led by AIDS Clinical Trial Group

Researchers identify first biomarker that appears to be associated with duration of delirium

Moderate consumption of alcohol can improve immune response to vaccination

Low vitamin D a consequence not a cause of ill health

Research roundup: Long-term care use varies dramatically by state; health spending slowdown explained

Research: Released prisoners seven times more likely to commit suicide than general population

IOF Young Investigator Awards presented to five researchers at 4th Asia-Pacific Osteoporosis Meeting

Early initiation of treatment after primary hip fracture helps reduce second fracture incidence, mortality

NJHA's CEO wins FDR Visionary Award from March of Dimes

Analysis provides first empirical evidence on how shared savings ACO model affect quality of care

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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