Clinical Trial News and Research

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Switching to a Western diet triggers inflammation and weakens immunity

A switch of just two weeks from a traditional African diet to a Western diet causes inflammation, reduces the immune response to pathogens, and activates processes associated with lifestyle diseases.

3 Apr 2025

New data on use of EndoZip™ to treat obese patients be presented at leading global medical conferences

Nitinotes, developer of EndoZip™, a fully automated endoscopic suturing system aimed at treating obesity, today announced that clinical research on the EndoZip™ system will be presented at upcoming leading international medical conferences.

3 Apr 2025

New drug strategy targets Staphylococcus aureus toxin to treat pneumonia

Pneumonia caused by the bacterium Staphylococcus aureus is one of the most dangerous infections that can occur in hospital.

2 Apr 2025

Blood cancer patients should continue BTKi therapy during COVID-19 vaccination

Blood cancer patients who receive a type of anti-cancer therapy should continue to take the drug while having COVID-19 vaccinations, a new study suggests.

2 Apr 2025

New AI system enhances nurse-driven patient monitoring and saves lives

An AI tool that analyzes nurses' data and notes detected when patients in the hospital were deteriorating nearly two days earlier than traditional methods and reduced the risk of death by over 35%, found a year-long clinical trial of more than 60,000 patients led by researchers at Columbia University.

2 Apr 2025

Study identifies key predictor of stroke and dementia

A research team from the University of Minnesota Medical School has identified a strong predictor of ischemic stroke and dementia, a discovery that could lead to improved patient outcomes.

1 Apr 2025

Virtual diabetes self-management interventions improve blood sugar levels

Relatively inexpensive and accessible self-management interventions to help people manage Type 2 diabetes have been found to significantly reduce the blood sugar marker used to diagnose and manage the disease.

1 Apr 2025

Cedars-Sinai study investigates diet's role in treating gut disorders

A new study from Cedars-Sinai examined whether a specialized diet could improve symptoms of gastrointestinal disorders linked to an imbalance in gut microbiota.

1 Apr 2025

UVA Health experts highlight a growing array of treatment options for type 2 diabetes

Nearly 40% of patients diagnosed with type 2 diabetes imperil their health by stopping their medication within the first year, UVA Health diabetes experts note in a new paper highlighting a growing array of treatment options.

1 Apr 2025

New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).

1 Apr 2025

WINREVAIR™ (sotatercept-csrk) reduced the risk of a composite of all-cause death, lung transplantation and hospitalization for pulmonary arterial hypertension (PAH) by 76% compared to placebo in the phase 3 ZENITH trial

Merck, known as MSD outside of the United States and Canada, today announced the first presentation of results from the Phase 3 ZENITH trial evaluating WINREVAIR™ (sotatercept-csrk) compared to placebo in adults with pulmonary arterial hypertension (PAH, Group 1 PH) WHO* functional class (FC) III or IV at high risk of mortality who were on maximum tolerated background PAH therapy. At a median follow-up of 10.6 months (range, 0.3-26.1), WINREVAIR reduced the relative risk of major morbidity and mortality events (the composite of all-cause death, lung transplantation and PAH worsening-related hospitalization of ≥24 hours) by 76% (HR=0.24 [95% CI, 0.13-0.43]; p<0.0001 [1-sided]) compared to placebo.

1 Apr 2025

A new blood test could improve how Alzheimer’s disease is diagnosed

The blood test for eMTBR-tau243 shows strong correlation with tau pathology, enhancing Alzheimer's diagnosis and monitoring cognitive decline effectively.

1 Apr 2025

Novo Nordisk A/S: Rybelsus® (oral semaglutide 14 mg) demonstrates superior reduction in cardiovascular events in the SOUL trial at ACC 2025

Novo Nordisk today presented the full results from the SOUL cardiovascular outcomes trial, demonstrating that Rybelsus® (oral semaglutide) significantly reduced the risk of major adverse cardiovascular events in adults with type 2 diabetes and cardiovascular disease (CVD) and/or chronic kidney disease (CKD).

1 Apr 2025

Study finds clues to hypertension hidden in electronic health records

A new study from investigators at Mass General Brigham shows that clues about hypertension may be buried in electronic health records (EHR).

1 Apr 2025

Mayo Clinic launches study to investigate rapidly progressive dementia in Alzheimer's

Most patients with Alzheimer's disease and Alzheimer's Disease Related Dementias (ADRD) experience the gradual onset and progression of cognitive symptoms, leading to decline over years or decades.

1 Apr 2025

Patient navigators boost follow-up colonoscopies and reduce delays

A University of Arizona Health Sciences-led study found that patients are more likely to get colonoscopies following abnormal stool test results if patient navigators assist them through the process.

31 Mar 2025

Research challenges traditional oxygen practices in trauma care

When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it's often less than the current standard.

31 Mar 2025

Speech neuroprosthesis unlocks near-real-time communication for patients with paralysis

Marking a breakthrough in the field of brain-computer interfaces (BCIs), a team of researchers from UC Berkeley and UC San Francisco has unlocked a way to restore naturalistic speech for people with severe paralysis.

31 Mar 2025

Trilogy valve demonstrates safety and effectiveness in treating aortic regurgitation

Patients who underwent transcatheter aortic valve replacement (TAVR) with a valve designed to treat aortic regurgitation had an overall mortality rate of just 8.1% at one year, well below the trial's prespecified goal of 25% to show non-inferiority, according to a study presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

31 Mar 2025

Embolic protection device does not reduce stroke rate in TAVR procedure

A device designed to remove embolic material—fragments of tissue that can be released into the bloodstream during transcatheter aortic valve replacement (TAVR)—did not result in a reduction in the rate of stroke, according to a randomized trial presented at the American College of Cardiology's Annual Scientific Session.

31 Mar 2025

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Clinical Trial News and Research

Switching to a Western diet triggers inflammation and weakens immunity

New data on use of EndoZip™ to treat obese patients be presented at leading global medical conferences

New drug strategy targets Staphylococcus aureus toxin to treat pneumonia

Blood cancer patients should continue BTKi therapy during COVID-19 vaccination

New AI system enhances nurse-driven patient monitoring and saves lives

Study identifies key predictor of stroke and dementia

Virtual diabetes self-management interventions improve blood sugar levels

Cedars-Sinai study investigates diet's role in treating gut disorders

UVA Health experts highlight a growing array of treatment options for type 2 diabetes

New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

WINREVAIR™ (sotatercept-csrk) reduced the risk of a composite of all-cause death, lung transplantation and hospitalization for pulmonary arterial hypertension (PAH) by 76% compared to placebo in the phase 3 ZENITH trial

A new blood test could improve how Alzheimer’s disease is diagnosed

Novo Nordisk A/S: Rybelsus® (oral semaglutide 14 mg) demonstrates superior reduction in cardiovascular events in the SOUL trial at ACC 2025

Study finds clues to hypertension hidden in electronic health records

Mayo Clinic launches study to investigate rapidly progressive dementia in Alzheimer's

Patient navigators boost follow-up colonoscopies and reduce delays

Research challenges traditional oxygen practices in trauma care

Speech neuroprosthesis unlocks near-real-time communication for patients with paralysis

Trilogy valve demonstrates safety and effectiveness in treating aortic regurgitation

Embolic protection device does not reduce stroke rate in TAVR procedure

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