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Imaxio's pro-immunogenic technology used in tuberculosis vaccine phase I clinical study

Imaxio, a biopharmaceutical company specializing in vaccines and genomics, announces today that IMX313, its proprietary pro-immunogenic technology, has been administered for the first time in humans in a tuberculosis vaccine phase I clinical study. The trial is being conducted by the Jenner Institute at Oxford University, England.

3 Sep 2013

Omecamtiv mecarbil fails to achieve primary endpoint in phase II ATOMIC-AHF study

Omecamtiv mecarbil, a cardiac myosin-activator, did not achieve its primary efficacy endpoint in reducing dyspnoea (shortness of breath) in patients with acute heart failure, according to the results of the phase II ATOMIC-AHF (Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure) study.

3 Sep 2013

Study assesses relationship between BMI and CV events in hypertensive patients with diabetes

Low BMI is a risk factor for CVD in hypertensive patients with diabetes, according to research presented at the ESC Congress today by Dr Takanori Nagahiro from Japan. The findings provide evidence for an obesity paradox in hypertensive patients with glucose intolerance.

3 Sep 2013

Authors of new paper outline possible factors to identify metabolically healthy obesity

Metabolically healthy obesity – where an individual has a Body Mass Index of greater than 30 but does not appear to be at increased risk of the health complications usually associated with excess weight – has only been recently widely recognised by medical practitioners.

3 Sep 2013

Facebook groups are effective tool for increasing HIV testing among at-risk populations

Peer-led Facebook groups are an acceptable and effective tool for increasing home-based HIV testing among at-risk populations. HIV infection is a major health concern for men who have sex with men (MSM), especially among African Americans and Latinos who have high rates of incident cases and new diagnoses.

3 Sep 2013

BP variability a long-term challenge

Blood pressure variability over the long term predicts mortality among patients receiving treatment for hypertension, a study shows.

2 Sep 2013

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

This rare genetic condition can theoretically affect patients at any age but symptoms are more often observed in childhood and even uncommonly during the first days of life.

2 Sep 2013

Women are 25% less likely to die post TAVI than men, says doctor

Dr Sherif said: "Earlier studies on the impact of gender on outcome after transcatheter aortic valve implantation (TAVI) have had conflicting results. A Canadian study reported in 641 consecutive patients that female sex is associated with a better long-term and short-term survival after TAVI.1 An Italian study of 305 high risk patients found no gender differences in composite safety and efficacy endpoints at 30 days and one year after TAVI."2

2 Sep 2013

TAVI is safe therapeutic option than redo cardiac surgery

Use of bioprosthetic heart valves has dramatically increased (from 18% in 1991 to 59% in 2003), mainly in older patients with comorbidities. This is due to the increased risk of bleeding complications associated with lifelong use of anticoagulation for mechanical prostheses.

2 Sep 2013

Average height of European males increased by 11cm between mid-19th century and 1980

The average height of European males increased by an unprecedented 11cm between the mid-nineteenth century and 1980, according to a new paper published online today in the journal Oxford Economic Papers. Contrary to expectations, the study also reveals that average height actually accelerated in the period spanning the two World Wars and the Great Depression.

2 Sep 2013

Mass screening programme of 75-76 year olds to identify undiagnosed AF

Stroke is the second cause of death worldwide. Atrial fibrillation is the most common clinically relevant cardiac arrhythmia in Europe, affecting approximately 1.5-2% of the general population.1 Prevalence is estimated to double in the next 50 years as the population ages.

2 Sep 2013

Anti-diabetic drug alogliptin meets primary endpoint in EXAMINE trial

Patients with type 2 diabetes and high cardiovascular risk due to recent acute coronary syndromes had similar rates of cardiovascular events when treated with the anti-diabetic agent alogliptin compared to placebo according to results of the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care trial presented at the European Society of Cardiology Congress.

2 Sep 2013

Pre-treatment with prasugrel increases risk of bleeding without reducing risk of ischemic events

In patients with non-ST-elevation acute coronary syndrome (NSTE- ACS), pre-treatment with the P2Y12 antagonist prasugrel prior to catheterization, significantly increases the risk of life-threatening bleeding without reducing the risk of major ischemic events, according to the results of the ACCOAST (A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction) trial.

2 Sep 2013

CAD patients with very low LDL-C levels benefit from statin treatment

Dr Nakano said: "Many randomised clinical trials, such as Treating to New Targets (TNT) and PROVE IT-TIMI, have shown that aggressive cholesterol lowering with statins improves clinical outcomes in patients with CAD and high LDL-C levels.1,2 But until now it was not known whether aggressive lipid lowering with statins would also benefit CAD patients with very low LDL-C levels."

2 Sep 2013

Despite living with highest risk factors for heart disease, people in high income countries suffer less

Despite living with the highest risk factors for heart disease, people in high income countries suffer less from serious cardiovascular disease, says an international study by the global PURE (Prospective Urban Rural Epidemiology ) collaboration and led by McMaster University researchers.

2 Sep 2013

High waist circumference associated with greatest risk of death in heart attack survivors

Having a big belly increases the risk of death in heart attack survivors, according to research presented at ESC Congress 2013 by Professor Tabassome Simon and Professor Nicolas Danchin from France.

2 Sep 2013

Life expectancy gap growing between older women in rich and poor countries: Study

Measures taken in developed countries to reduce noncommunicable diseases - the leading causes of death globally - have improved the life expectancy of women aged 50 years and older over the last 20 to 30 years.

2 Sep 2013

LNHASC selects Clinical Outcomes Management Systems Interactive as Preferred Partner

The Louisiana Nursing Home Association Service Corporation (LNHASC) has chosen COMS Interactive, LLC (Clinical Outcomes Management Systems or COMS) as a Preferred Partner.

31 Aug 2013

Research roundup: Assessing new hospital observation rule; doctors' view of DNR orders for kids

Hospitalized patients in the United States are increasingly placed on "observation status." The Centers for Medicare & Medicaid Services (CMS) state that observation should rarely exceed 48 hours.

31 Aug 2013

Still no evidence for causes of Alzheimer's disease by playing football, despite NFL settlement

Despite the NFL's $765 million settlement with retired players, there still is no credible scientific evidence that playing football causes Alzheimer's disease or other neurological disorders, according to Loyola University Medical Center clinical neuropsychologist Christopher Randolph, PhD, who has published multiple studies on the topic.

31 Aug 2013

Mortality News and Research

Imaxio's pro-immunogenic technology used in tuberculosis vaccine phase I clinical study

Omecamtiv mecarbil fails to achieve primary endpoint in phase II ATOMIC-AHF study

Study assesses relationship between BMI and CV events in hypertensive patients with diabetes

Authors of new paper outline possible factors to identify metabolically healthy obesity

Facebook groups are effective tool for increasing HIV testing among at-risk populations

BP variability a long-term challenge

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

Women are 25% less likely to die post TAVI than men, says doctor

TAVI is safe therapeutic option than redo cardiac surgery

Average height of European males increased by 11cm between mid-19th century and 1980

Mass screening programme of 75-76 year olds to identify undiagnosed AF

Anti-diabetic drug alogliptin meets primary endpoint in EXAMINE trial

Pre-treatment with prasugrel increases risk of bleeding without reducing risk of ischemic events

CAD patients with very low LDL-C levels benefit from statin treatment

Despite living with highest risk factors for heart disease, people in high income countries suffer less

High waist circumference associated with greatest risk of death in heart attack survivors

Life expectancy gap growing between older women in rich and poor countries: Study

LNHASC selects Clinical Outcomes Management Systems Interactive as Preferred Partner

Research roundup: Assessing new hospital observation rule; doctors' view of DNR orders for kids

Still no evidence for causes of Alzheimer's disease by playing football, despite NFL settlement

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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