Genes News and Research

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Linking human genome sequences to EHR information could influence clinical medicine, says expert

The value of intersecting the sequencing of individuals' exomes or full genomes to find rare genetic variants -- on a large scale -- with their detailed electronic health record information has "myriad benefits, including the illumination of basic human biology, the early identification of preventable and treatable illnesses, and the identification and validation of new therapeutic targets," wrote Daniel J. Rader, MD, chair of the Department of Genetics, in the Perelman School of Medicine at the University of Pennsylvania, in Science this week, with Scott M. Damrauer, MD, an assistant professor of Surgery at Penn and the Veterans Affairs Medical Center in Philadelphia.

23 Dec 2016

UC researchers uncover obesity-related protein's role in leukemia development

Cancer researchers at the University of Cincinnati College of Medicine have found an obesity-associated protein's role in leukemia development and drug response which could lead to more effective therapies for the illness.

22 Dec 2016

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

An international team of scientists has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria -- the energy-producing factory of the cell -- and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans.

22 Dec 2016

Making muscles burn more fat and less glucose could cause diabetes, say researchers

Making muscles burn more fat and less glucose can increase exercise endurance, but could simultaneously cause diabetes, says a team of scientists from Baylor College of Medicine and other institutions.

22 Dec 2016

Scientists identify gene variants causing unrecognized developmental disorder

An international team of scientists has identified variants of the gene EBF3 causing a developmental disorder with features in common with autism.

22 Dec 2016

New computational tool can predict personal cancer driver genes to optimize treatment

Columbia University Medical Center researchers have created a computational tool that can rapidly predict which genes are implicated in an individual's cancer and recommend treatments.

22 Dec 2016

New study explores circadian timekeeping to create genetic knock-out rescue mice

A new study from the laboratory of Hiroki Ueda at the RIKEN Quantitative Biology Center investigates circadian timekeeping with a novel approach to creating genetic knock-out rescue mice.

22 Dec 2016

Gene testing could help predict ovarian cancer patients' sensitivity to new class of drugs

Testing for a gene commonly mutated in ovarian cancers could pick out patients who will respond well to a promising new class of cancer drugs, a major new study reveals.

22 Dec 2016

Discrimination interacts with certain genetic variants to negatively impact health

It's no secret that discrimination is stressful for those who experience it, but turns out the issue is more than skin deep—these stressors can interact with our genetics to negatively impact our health, a new University of Florida study shows.

22 Dec 2016

High BMI leads to epigenetic changes, study shows

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA.

22 Dec 2016

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Clinical Genomics introduces new blood-based test for CRC recurrence monitoring

Clinical Genomics, a private company developing evidence-based diagnostic tools for colorectal cancer, today announced the launch of Colvera, a blood-based test for colorectal cancer (CRC) recurrence monitoring. Colvera is the result of a decade of research, development and clinical validation in more than 4,000 patients.

22 Dec 2016

Combined genetic disruptions can counteract premature aging, TSRI study suggests

In a new study, scientists from the Florida campus of The Scripps Research Institute have shown how two genes "balance" each other to maintain normal cell function.

22 Dec 2016

Music may regulate mood, emotional responses at behavioral and neuronal level

Sounds, such as music and noise, are capable of reliably affecting individuals' moods and emotions, possibly by regulating brain dopamine, a neurotransmitter strongly involved in emotional behavior and mood regulation.

21 Dec 2016

Fly study shows RNA pathway plays major role in normal health and longevity

Humans and other animals carry rogue sequences of DNA in their genomes called transposable elements. To prevent passing TEs to their offspring, they employ the piRNA pathway in their reproductive organs to block the elements from being active in their sperm and eggs.

21 Dec 2016

Research sheds new light on key drivers of cancer metastasis

Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumours to other parts of the body. This phenomenon - known as metastasis - causes about 90 per cent of all cancer deaths.

21 Dec 2016

Researchers engineer promising live-attenuated RSV vaccine candidate

Crafting a vaccine against RSV (respiratory syncytial virus) has been a minefield for 50 years, but scientists believe they have found the right balance.

21 Dec 2016

MedUni Vienna scientists show that addictive cravings can be detected after death

A protein known as FosB in the reward centre of the brain alters in chronically ill people suffering from an addictive disorder (e.g. heroin addiction): it is genetically modified, split off and shortened.

21 Dec 2016

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Professor Frédéric Veyrier's most recent research, in collaboration with the team of Professor Hilde De Reuse at the Institut Pasteur, has shed light on key genes essential to the pathogenesis of Helicobacter pylori bacterium, which causes gastric infections.

21 Dec 2016

Hormone receptor could be potential biomarker for gastric cancer, research shows

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, the Veterans Affairs Medical Center in Miami, and Shantou University Medical College in China, have shown that the hormone receptor GHRH-R could be a potential biomarker for gastric cancer, enabling earlier diagnoses and better staging.

21 Dec 2016

Genes News and Research

Linking human genome sequences to EHR information could influence clinical medicine, says expert

UC researchers uncover obesity-related protein's role in leukemia development

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

Making muscles burn more fat and less glucose could cause diabetes, say researchers

Scientists identify gene variants causing unrecognized developmental disorder

New computational tool can predict personal cancer driver genes to optimize treatment

New study explores circadian timekeeping to create genetic knock-out rescue mice

Gene testing could help predict ovarian cancer patients' sensitivity to new class of drugs

Discrimination interacts with certain genetic variants to negatively impact health

High BMI leads to epigenetic changes, study shows

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Clinical Genomics introduces new blood-based test for CRC recurrence monitoring

Combined genetic disruptions can counteract premature aging, TSRI study suggests

Music may regulate mood, emotional responses at behavioral and neuronal level

Fly study shows RNA pathway plays major role in normal health and longevity

Research sheds new light on key drivers of cancer metastasis

Researchers engineer promising live-attenuated RSV vaccine candidate

MedUni Vienna scientists show that addictive cravings can be detected after death

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Hormone receptor could be potential biomarker for gastric cancer, research shows

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