Amyotrophic Lateral Sclerosis (ALS) News and Research

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Research reveals surprising genetic overlap between neurological and psychiatric disorders

Researchers compared the shared genetic risk and biological foundations of neurological and mental illnesses.

1 Aug 2023

Hundreds of proteins and mRNA molecules mislocated in ALS nerve cells

Researchers at the Francis Crick Institute and UCL have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS).

21 Jul 2023

Study highlights the potential of cell replacement therapy for Huntington's disease

New research appearing in the journal Nature Biotechnology answers important questions about the viability of treatments that seek to replace diseased and aged cells in the central nervous system with healthy ones.

17 Jul 2023

Study suggests anxiety increases the risk of subsequent cognitive progression in non-dementia elderly

Researchers investigate the effects of anxiety on cognitive degeneration in non-dementia elderly.

14 Jul 2023

Study shows potential for treating ALS with two existing drugs

New research suggests that targeting autoimmune inflammation associated with amyotrophic lateral sclerosis (ALS) using two drugs, one of them already approved for multiple sclerosis, could be a promising approach for treatment.

12 Jul 2023

Eating foods high in omega-3 fatty acids may lead to slower physical decline in people with ALS

People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival.

21 Jun 2023

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

UBQLN2 dysfunction in ALS leads to elevated PEG10 levels, suggesting a role for retrotransposon activity in the disease. PEG10's nuclear localization alters gene expression involved in axon remodeling, implicating it as a contributing mechanism in ALS.

7 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Researchers at Nagoya University in Japan have discovered a receptor, sigma-1 receptor, and a protein, ATAD3A, that are associated with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.

25 Apr 2023

Using engineered stem cells to treat ALS and retinitis pigmentosa

Cedars-Sinai investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.

20 Apr 2023

Cold temperature plays a central role in longevity

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

3 Apr 2023

Designer DNA drug could be used to delay paralysis in ALS

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

17 Mar 2023

Innate immune molecule could be at the root of ALS

While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures.

13 Mar 2023

Newly identified therapeutic target could lead to more effective treatment of glaucoma

Indiana University School of Medicine researchers have identified a new therapeutic target that could lead to more effective treatment of glaucoma.

10 Mar 2023

Using artificial intelligence methods to predict the prevalence of ALS

Amyotrophic lateral sclerosis (ALS)—a severe disease of the motor nervous system—is hereditary, but a large part of this heritability has previously been unexplained.

28 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Soft robotic wearable can assist ALS patients with upper arm and shoulder movement

A team of researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Massachusetts General Hospital (MGH) has developed a soft robotic wearable capable of significantly assisting upper arm and shoulder movement in people with ALS.

3 Feb 2023

Amyotrophic Lateral Sclerosis (ALS) News and Research

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Hundreds of proteins and mRNA molecules mislocated in ALS nerve cells

Study highlights the potential of cell replacement therapy for Huntington's disease

Study suggests anxiety increases the risk of subsequent cognitive progression in non-dementia elderly

Study shows potential for treating ALS with two existing drugs

Eating foods high in omega-3 fatty acids may lead to slower physical decline in people with ALS

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Using engineered stem cells to treat ALS and retinitis pigmentosa

Cold temperature plays a central role in longevity

Designer DNA drug could be used to delay paralysis in ALS

Innate immune molecule could be at the root of ALS

Newly identified therapeutic target could lead to more effective treatment of glaucoma

Using artificial intelligence methods to predict the prevalence of ALS

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Soft robotic wearable can assist ALS patients with upper arm and shoulder movement

Study offers clues about the biology of cells in the spinal cord that die off in ALS

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

Epidemiological evidence that Alzheimer's and Parkinson's could be caused by viral infections

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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