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New triplet therapies show promise for relapsed and newly diagnosed leukemias

Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias.

9 Dec 2024

Scientists link proteins to Alzheimer’s through cutting-edge genetic method

Researchers have developed MR-SPI, a novel method integrated with AlphaFold3, to identify causal protein biomarkers and predict their 3D structural changes in Alzheimer’s disease. This breakthrough offers insights into disease mechanisms and potential therapeutic targets.

5 Dec 2024

How carrageenan affects insulin resistance

A randomized controlled trial found that carrageenan, a common food additive, may cause subclinical inflammation and insulin resistance in overweight individuals, mediated by gut permeability and inflammation. Effects were linked to BMI but not observed in non-overweight participants during short-term exposure.

3 Dec 2024

Adults with egg white allergy face significant quality of life challenges

Study reveals significant impairments in the quality of life for adults with hen's egg white allergy, highlighting the need for accurate food labeling and further research into effective treatments.

27 Nov 2024

PD-1 deficiency reveals the impact of checkpoint inhibition on B cell function

A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint inhibitors experience increased susceptibility to common infections.

27 Nov 2024

New clinical trial offers hope for patients with rare immune disease IgG4-RD

A team led by Mass General Brigham researchers demonstrated that inebilizumab reduced the risk of symptoms by 87% in patients with the rare affliction known as immunoglobulin G4–related disease (IgG4-RD)

18 Nov 2024

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

An international, phase 3 clinical trial led by investigators at Mass General Brigham could improve the treatment of a rare disease that can cause debilitating symptoms.

14 Nov 2024

Maternal RSV vaccination timing optimizes newborn immunity through improved antibody transfer

Maternal RSV vaccination enhances antibody transfer to newborns, with optimal transfer efficiency observed when given at least five weeks before delivery.

14 Nov 2024

Update on diagnosis, risk classification and treatment of Kawasaki Disease

Advances in cardiac imaging techniques and risk categorization have led to improvements in diagnosis, initial treatment and long-term management of patients with Kawasaki Disease, according to a new scientific statement published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

14 Nov 2024

Thrombotic thrombocytopenic purpura cases after CoronaVac raise concerns over vaccine safety

The COVID-19 pandemic has prompted the rapid development and administration of various vaccines worldwide, with some reports linking these vaccines to immune thrombotic thrombocytopenic purpura (TTP).

8 Nov 2024

Emerging therapies transform autoimmune hepatitis treatment approaches

Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure.

6 Nov 2024

One in four healthy young Marines report long-term physical, cognitive, or psychiatric effects after mild COVID-19

Researchers examine the long-term health effects of SARS-CoV-2 infection in a cohort of United States Marines.

29 Oct 2024

New single-chain mRNA vaccines offer enhanced immunity and protection against mpox

Study reveals single-chain mRNA vaccines confer 100% protection against lethal mpox challenge in mice, marking a significant advancement in vaccine technology.

22 Oct 2024

A deeper look at COVID-19 transmission and fetal health

A new Cleveland Clinic-led study published in The EMBO Journal shows that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in a pregnant individual that may cause serious inflammatory responses in the developing fetus.

17 Oct 2024

New test developed to simplify the diagnosis of allergies

Researchers at the University of Bern and Bern University Hospital have developed a test to simplify the diagnosis of allergies.

15 Oct 2024

Exploring the role of gut microbes in the aging process

Aging is a universal and complex process affecting all organisms, characterized by several genetic hallmarks such as telomere attrition, genomic instability, and epigenetic changes.

9 Oct 2024

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

Long-lived plasma cells fail to establish after COVID mRNA vaccination, limiting long-term antibody response

Researchers found that SARS-CoV-2-specific plasma cells were largely excluded from the long-lived plasma cell compartment in the bone marrow after mRNA vaccination, explaining the short-lived antibody response.

2 Oct 2024

Cleveland Clinic identifies bacterium that weakens gut immune defense

Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.

26 Sep 2024

Johnson & Johnson seeks first approval of nipocalimab to treat broadest population living with antibody positive generalized myasthenia gravis

The BLA submission for nipocalimab marks a significant advancement in treating generalized myasthenia gravis, showing improved MG-ADL scores in clinical trials.

From Johnson & Johnson 24 Sep 2024

Immunoglobulin News and Research

New triplet therapies show promise for relapsed and newly diagnosed leukemias

Scientists link proteins to Alzheimer’s through cutting-edge genetic method

How carrageenan affects insulin resistance

Adults with egg white allergy face significant quality of life challenges

PD-1 deficiency reveals the impact of checkpoint inhibition on B cell function

New clinical trial offers hope for patients with rare immune disease IgG4-RD

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

Maternal RSV vaccination timing optimizes newborn immunity through improved antibody transfer

Update on diagnosis, risk classification and treatment of Kawasaki Disease

Thrombotic thrombocytopenic purpura cases after CoronaVac raise concerns over vaccine safety

Emerging therapies transform autoimmune hepatitis treatment approaches

One in four healthy young Marines report long-term physical, cognitive, or psychiatric effects after mild COVID-19

New single-chain mRNA vaccines offer enhanced immunity and protection against mpox

A deeper look at COVID-19 transmission and fetal health

New test developed to simplify the diagnosis of allergies

Exploring the role of gut microbes in the aging process

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Long-lived plasma cells fail to establish after COVID mRNA vaccination, limiting long-term antibody response

Cleveland Clinic identifies bacterium that weakens gut immune defense

Johnson & Johnson seeks first approval of nipocalimab to treat broadest population living with antibody positive generalized myasthenia gravis

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