Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Dandelion leaves boost brain-protective compounds after digestion

Dandelion leaves are rich in polyphenols with neuroprotective effects, offering insights into natural strategies for Alzheimer's disease management.

27 Mar 2026

New brain atlas reveals how the human neocortex forms over time

In a bid to better understand, and potentially treat, a host of conditions that affect early cognition, neurodevelopment and the brain later in life, investigators at Johns Hopkins Medicine and colleagues throughout the world have been mapping the molecular construction of the human brain.

25 Mar 2026

Mediterranean diet may protect health through mitochondrial microproteins

A new study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondria, opening a new window into how diet shapes aging and disease risk.

23 Mar 2026

New protein atlas identifies distinct subtypes of neurodegenerative diseases

Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children's Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA).

23 Mar 2026

Oral semaglutide fails to slow early Alzheimer’s decline in two phase 3 trials

Two large phase 3 trials found that oral semaglutide 14 mg did not slow cognitive or functional decline over 104 weeks in people with early symptomatic, amyloid-positive Alzheimer’s disease. Semaglutide was generally consistent with its known safety profile and showed some biomarker changes, but these did not translate into clinical benefit.

22 Mar 2026

Brain lesions in Down syndrome show unexpected reversible changes

What has long been interpreted as permanent and irreversible vascular damage may not be exclusively so.

19 Mar 2026

MIND diet may protect against structural brain deterioration

The combined Mediterranean and blood pressure lowering diet (MIND) may slow the structural changes related to brain aging, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

17 Mar 2026

Vitamin B2 metabolism helps cancer cells resist ferroptosis

A lack of vitamin B2 makes tumour cells more susceptible to a unique form of cell death. This was discovered by researchers at the Rudolf Virchow Centre at the University of Würzburg.

13 Mar 2026

FDA-approved drug fedratinib enhances communication between cellular organelles

Cells behave like cities and organelles carry out infrastructural roles: Mitochondria are powerhouses, the endoplasmic reticulum serves as a transport hub and lysosomes help with waste disposal.

13 Mar 2026

New study identifies specific brain cells most vulnerable to ALS and dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments.

12 Mar 2026

How the aging gastrointestinal tract drives age-related cognitive decline

We become forgetful as we age. This is often seen as a universal truth, but in fact it is far from universal: some people remain incredibly sharp at 100 years old, while others experience memory loss starting in middle age.

11 Mar 2026

Scientists map epigenetic changes across aging brain cells

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years.

11 Mar 2026

Study links p-tau217 levels to long-term dementia risk in women

Researchers from the University of California San Diego have found that a novel blood-based biomarker can predict a woman's risk of developing dementia as many as 25 years before symptoms appear.

10 Mar 2026

Researchers develop DNA aptamer to detect Alzheimer's biomarkers

With aging populations on the rise, the need for better tools to diagnose and monitor Alzheimer's disease (AD), the most common cause of dementia, has never been more urgent.

10 Mar 2026

Tubulin prevents toxic protein clumps linked to neurodegeneration

Researchers at Baylor College of Medicine have discovered a potential new strategy to fight back against Alzheimer's and Parkinson's diseases, conditions that are linked to the toxic accumulation of Tau and alpha synuclein protein clumps in the brain.

6 Mar 2026

Scientists identify ANKIB1 as key regulator of innate immune signaling

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders.

6 Mar 2026

New European project develops human-based models for brain disorders

The University of Barcelona is consolidating its position at the forefront of European research thanks to the strategic project "VISI-ON-BRAIN: Cutting-edge Human In Vitro and In Silico Biomedical Tools on Brain Disorders".

6 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026

Study reveals a disease-relevant role for tanycytes in neurodegeneration

Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau.

5 Mar 2026