RNA Sequencing News and Research

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Study reveals cellular and metabolic landscape of lymph node metastasis in breast cancer

A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that drive the spread of breast cancer.

2 Mar 2026

NLRP3 inflammasome plays dual, time-dependent roles during acute wound healing

Wound healing is a multistep biological process involving inflammation, tissue formation, and remodeling.

2 Mar 2026

MERLIN algorithm unlocks immune cell location memory in organs

A new AI-based method reconstructs spatial information about where immune cells were originally located in an organ, even after these cells have been removed from the tissue and analyzed individually.

2 Mar 2026

Investigating microglia’s role in Alzheimer’s pathology

Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark.

1 Mar 2026

Study reveals pancreatic cancer's early immune evasion tactics

A new study suggests that pancreatic cancer may start preparing to "hide" from the immune system long before the disease becomes full-blown cancer.

27 Feb 2026

New biomarkers for targeted gastric therapy

HER2-positive gastric cancer accounts for a substantial proportion of advanced cases and has long been treated with HER2-targeted therapies. While trastuzumab deruxtecan has shown superior activity compared with earlier agents, most patients either fail to respond initially or eventually develop resistance.

26 Feb 2026

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

26 Feb 2026

New mouse model uncovers achondroplasia's cellular growth plate dysregulation

Achondroplasia, also known as short-limb dwarfism, is associated with neurological symptoms and complications due to narrowing of the skeletal structures surrounding the spinal cord.

26 Feb 2026

Study identifies mitochondrial circular RNAs in aging and senescence

A new research paper was published in Volume 18 of Aging-US on February 10, 2026, titled "Aging-associated mitochondrial circular RNAs."

24 Feb 2026

Single-cell RNA sequencing reveals accelerated T cell aging in viral infections

A new research paper was published in Volume 18 of Aging-US on February 8, 2026, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV."

19 Feb 2026

New technology maps protein production across individual brain cells

The brain's ability to carry out everything from forming memories to coordinating movement depends on its cells producing the right proteins at the right time.

18 Feb 2026

Researchers find new way to halt leukemia stem cell growth

In a new study published in Nature Communications, a research team at the University of Oslo have examined how cancer cells develop in the bone marrow and whether it might be possible to stop them.

18 Feb 2026

HER2 gastric cancer: Unraveling resistance at single-cell resolution

HER2-positive gastric cancer accounts for a substantial proportion of advanced cases and has long been treated with HER2-targeted therapies.

16 Feb 2026

Study explores how reversible RNA editing could transform future cardiovascular medicine

This mini-review synthesises evidence showing that adenosine-to-inosine RNA editing plays an important regulatory role in cardiovascular development, cellular homeostasis, and disease biology. It highlights emerging links between dysregulated RNA editing and cardiovascular conditions while outlining biomarker potential and reversible RNA-editing therapeutic strategies that remain under investigation.

15 Feb 2026

Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation

Intranasal boosting after prior intramuscular COVID vaccination induced strong mucosal IgA responses in a small human cohort. These antibodies showed markedly enhanced neutralising activity against Omicron variants and evidence of immune memory reprogramming toward mucosal protection.

15 Feb 2026

Causal gene mapping identifies key drivers of Alzheimer's disease progression

Researchers led by Min Zhang and Dabao Zhang of the University of California, Irvine's Joe C. Wen School of Population & Public Health have created the most detailed maps to date showing how genes causally regulate one another across different types of brain cells affected by Alzheimer's disease.

13 Feb 2026

Tahoe Therapeutics generates the largest single-cell atlas ever using INTEGRA Biosciences automated pipetting technologies

Tahoe Therapeutics - a biotech start-up based in San Francisco, California - is creating the largest ever atlas of cell-chemical interactions to inform drug discovery. Combining automated pipetting systems from INTEGRA Biosciences, Parse Biosciences' Evercode™ single-cell RNA sequencing (scRNA-seq) products, and its own proprietary AI algorithms, the company already has several drug discovery programs running in parallel across multiple cancer types, and is expanding into other therapeutic areas.

12 Feb 2026