Genes News and Research

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PCSK9 and HMGCR genetic variations that lower bad cholesterol affect risk of cardiovascular events

In a new study published in the December 1, 2016 issue of The New England Journal of Medicine, researchers at Brigham and Women's Hospital, and a collaboration of international researchers, studied variants in the genes encoding HMGCR and PCSK9 that affect cholesterol levels, and found that variants that lowered LDL (or "bad") cholesterol in each gene were associated with nearly identical protective effects on the risk of cardiovascular events per unit reduction in LDL cholesterol.

30 Nov 2016

Allen Institute for Cell Science releases gene edited, fluorescently tagged human iPS cells

The Allen Institute for Cell Science has released the Allen Cell Collection: the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells that target key cellular structures with unprecedented clarity.

30 Nov 2016

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified a small RNA (microRNA) that may be essential to restoring normal function in a brain circuit associated with the "voices" and other hallucinations of schizophrenia.

30 Nov 2016

Discovery of four genes linked to fatal aneurysms could provide potential target for treatments

Thousands of lives could be saved every year after it was discovered a fatal cardiovascular condition could be linked to four genes, research has found.

30 Nov 2016

Dirt beneath New York City may provide new weapons to fight against disease

Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.

29 Nov 2016

Scientists develop safe, highly efficient method to improve searching of new germicides

Scientists from the Lomonosov Moscow State University in cooperation with colleagues have worked out a safe, not that expensive and highly efficient method, which allows to speed up and improve searching of new germicides.

29 Nov 2016

Early life history and genetics may play crucial role in shaping gut microbiome

Genetics and birthplace have a big effect on the make-up of the microbial community in the gut, according to research published Nov. 28. in the journal Nature Microbiology.

29 Nov 2016

Scientists develop easy-to-use software tool to detect important genetic mutations

Scientists have developed an easy-to-use software tool that can detect important genetic mutations that previously needed to be identified by a separate test.

29 Nov 2016

DNA changes in blood samples could pave way for simple tests to diagnose IBD

Scientists have identified chemical changes in the DNA of patients with inflammatory bowel diseases that could improve screening for the conditions.

28 Nov 2016

Editing preferences of enzymes may play role in infertility and cancer

To "turn off" particular regions of genes or protect them from damage, DNA strands can wrap around small proteins, called histones, keeping out all but the most specialized molecular machinery.

28 Nov 2016

Gene mutation appears to increase risk of Parkinson's disease in Caucasians

A defect in a gene that produces dopamine in the brain appears to accelerate the onset of Parkinson's disease, according to new research from Iowa State University. The effect is particularly dramatic for people under age 50.

28 Nov 2016

ASGCT seeks to educate public and policy-makers on fundamentals of gene editing

On Nov. 21, 2016, the American Society of Gene & Cell Therapy released Therapeutic Gene Editing: an ASGCT White Paper, intended to provide policy-makers, patient advocates, and the interested public with the necessary background information in anticipation of an upcoming consensus report on human gene editing from the National Academy of Sciences and National Academy of Medicine (NAS), expected to be released in early 2017.

24 Nov 2016

Tissue damage plays crucial role in cell reprogramming

Cell reprogramming does not happen exactly as we thought. In the pages of the journal Science, a team from the Spanish National Cancer Research Centre has shown that tissue damage is a relevant factor for cells to go back to an embryonic state.

24 Nov 2016

Social status affects immune regulation and health status in rhesus monkeys

The richest and poorest Americans differ in life expectancy by more than a decade. Glaring health inequalities across the socioeconomic spectrum are often attributed to access to medical care and differences in habits such as smoking, exercise and diet.

24 Nov 2016

New ULB study shows how cancer cell of origin controls malignant transition

Researchers at the Université libre de Bruxelles, ULB define for the first time how the cancer cell of origin controls invasive and metastatic properties of tumor cells.

24 Nov 2016

Neurons appear to retain partial communication despite serious structural aberrations, study finds

Neuroscientists have long known that brain cells communicate with each other through the release of tiny bubbles packed with neurotransmitters—a fleet of vessels docked along neuronal ends ready to launch when a trigger arrives.

24 Nov 2016

Cancer gene mutations can predict response to less intensive treatment in AML patients

Patients with the most lethal form of acute myeloid leukemia (AML) - based on genetic profiles of their cancers - typically survive for only four to six months after diagnosis, even with aggressive chemotherapy.

23 Nov 2016

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes.

23 Nov 2016

HSCI researchers use color tagging system to track development of blood stem cells

Harvard Stem Cell Institute (HSCI) researchers have used a colorful, cell-labeling technique to track the development of the blood system and trace the lineage of adult blood cells travelling through the vast networks of veins, arteries, and capillaries back to their parent stem cell in the marrow.

23 Nov 2016

New research provides insights into how gut microbes drive host gene expression

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance.

23 Nov 2016

Genes News and Research

PCSK9 and HMGCR genetic variations that lower bad cholesterol affect risk of cardiovascular events

Allen Institute for Cell Science releases gene edited, fluorescently tagged human iPS cells

Scientists identify microrna that provides clues for quieting auditory hallucinations of schizophrenia

Discovery of four genes linked to fatal aneurysms could provide potential target for treatments

Dirt beneath New York City may provide new weapons to fight against disease

Scientists develop safe, highly efficient method to improve searching of new germicides

Early life history and genetics may play crucial role in shaping gut microbiome

Scientists develop easy-to-use software tool to detect important genetic mutations

DNA changes in blood samples could pave way for simple tests to diagnose IBD

Editing preferences of enzymes may play role in infertility and cancer

Gene mutation appears to increase risk of Parkinson's disease in Caucasians

ASGCT seeks to educate public and policy-makers on fundamentals of gene editing

Tissue damage plays crucial role in cell reprogramming

Social status affects immune regulation and health status in rhesus monkeys

New ULB study shows how cancer cell of origin controls malignant transition

Neurons appear to retain partial communication despite serious structural aberrations, study finds

Cancer gene mutations can predict response to less intensive treatment in AML patients

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

HSCI researchers use color tagging system to track development of blood stem cells

New research provides insights into how gut microbes drive host gene expression

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