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Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Metastatic bladder cancer is generally incurable, so new therapies are an urgent need. Researchers at the University of Alabama at Birmingham now report a potential treatment for a quarter of bladder cancers.

4 Aug 2022

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers develop a genetically modified airway organoid system, which overcomes challenges related to natural variations in ACE2 levels

4 Aug 2022

How does the flu vaccine affect the risk of contracting COVID-19?

A new study describes the association between the risk of contracting COVID-19 and the seasonal flu vaccine.

4 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Mitochondria are organelles found within most cells, best known for generating the chemical energy required to power cellular functions.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Scientists develop a novel, highly-efficient sample preparation method for single-cell proteomics

The proteins that make up our cells hold within an entire world of information, which, when unlocked, can give us insights into the origins of many essential biological phenomena.

4 Aug 2022

Study shows how microglia contribute to slowdown of neuron activity linked with Alzheimer’s

One of the hallmarks of Alzheimer's disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience.

4 Aug 2022

Polymer-embedded copper-based nanoparticles prevent surface contamination by viruses

In a new study, researchers developed nanocomposite coatings to prevent surface contamination by a human coronavirus (HCoV).

4 Aug 2022

Researchers identify a component in the intestine that plays key role in repairing damaged tissue

Investigators at Cedars-Sinai and the University of California, San Francisco have identified a component in the intestine that plays a critical role in repairing damaged tissue.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

Disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 variants

Researchers compared the severity levels of disease caused by different SARS-CoV-2 variants of concern in the rhesus macaque model.

4 Aug 2022

Fully reduced form of vitamin K found to efficiently inhibit ferroptotic cell death

A team of researchers at Tohoku University has reported on a novel function of vitamin K, which is generally known for its importance in blood clotting.

4 Aug 2022

Large-scale serological survey of SARS-CoV-2 in multiple rodent species across Europe

Scientists conducted SARS-CoV-2 sero-surveillance in wild rodents across Europe.

4 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Hybrid immunity retained six months after SARS-CoV-2 exposure

Scientists hypothesize that lower death rates in COVID-19 patients may be due to hybrid immunity, as well as the reduced severity of Omicron infections.

3 Aug 2022

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Researchers at Queen's University Belfast have received funding from Breast Cancer Now to search for new treatments inspired by COVID-19 vaccine innovation.

3 Aug 2022

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress - an imbalance in the normal oxidation/reduction, or redox, homeostasis - caused pathological changes associated with heart failure in a mouse model.

3 Aug 2022

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism.

3 Aug 2022

Cell News and Research

Researchers discover two signaling pathways that are downregulated in human hearts after birth

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

How does the flu vaccine affect the risk of contracting COVID-19?

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Scientists develop a novel, highly-efficient sample preparation method for single-cell proteomics

Study shows how microglia contribute to slowdown of neuron activity linked with Alzheimer’s

Polymer-embedded copper-based nanoparticles prevent surface contamination by viruses

Researchers identify a component in the intestine that plays key role in repairing damaged tissue

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

Disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 variants

Fully reduced form of vitamin K found to efficiently inhibit ferroptotic cell death

Large-scale serological survey of SARS-CoV-2 in multiple rodent species across Europe

A combined influenza and COVID-19 mRNA vaccine

Hybrid immunity retained six months after SARS-CoV-2 exposure

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

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