Pathophysiology News and Research

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Low HDL cholesterol ADVANCEs nephropathy risk in diabetes

People with diabetes are at a greater risk for the development or progression of diabetic nephropathy if they have low levels of high-density lipoprotein cholesterol, report researchers.

15 Aug 2012

White matter abnormalities distinguish childhood-onset BD

Increased white matter microstructure abnormalities may differentiate pediatric- from adult-onset bipolar disorder, results from a US study suggest.

15 Aug 2012

Schizophrenia and the immune system: an interview with Prof Cyndi Shannon Weickert

Schizophrenia is the most disabling disease impacting youth today. It impacts 1% of the total population and typically causes withdrawal from society, loss in IQ, disordered thought and speech, hallucinations and delusions.

14 Aug 2012

Glutamatergic system involvement in BD supported

Results from a systematic review and meta-analysis of published studies suggest that brain levels of glutamate plus glutamine are elevated in bipolar disorder patients compared with mentally healthy individuals.

2 Aug 2012

Hint of tafamidis benefit in rare polyneuropathy

The results of a randomized trial suggest that tafamidis treatment may slow the progression of early-stage V30M transthyretin familial amyloid polyneuropathy.

2 Aug 2012

Sickle cell trait link with sudden athlete death ‘confirmed’

Researchers say they have definitively confirmed that there is a link between the sickle cell trait and sudden cardiac death in African–American athletes.

2 Aug 2012

Evidence for ADHD due to delay in brain development

Is attention-deficit/hyperactivity disorder (ADHD) due to a delay in brain development or the result of complete deviation from typical development? In the current issue of Biological Psychiatry, Dr. Philip Shaw and colleagues present evidence for delay based on a study by the National Institutes of Health.

30 Jul 2012

Altered default network connectivity in FEP patients

Patients with a first episode of psychosis show altered functional connectivity in the dorsomedial prefrontal cortex default network subsystem, researchers report.

27 Jul 2012

Insomnia: an interview with Dr Darryle Schoepp

Insomnia is a very common disorder. In medical terms it can affect a third of people. It affects elderly as well as non-elderly people, and is more common in women.

26 Jul 2012

New classification scheme for psychiatric symptoms

The traditional approach to psychiatric diagnosis is based on grouping patients on the basis of symptom clusters. This approach to diagnosis has a number of problems, as symptoms are not necessarily specific to a single diagnosis.

25 Jul 2012

Reward-related decision making may be affected by the emotional processing system

Anxiety disorders affect approximately 40 million American adults each year, and although they are treatable, they often cause significant distress.

23 Jul 2012

Micrographia prevalent in Parkinson’s

Around half of patients with Parkinson’s disease display symptoms of micrographia, a case–control study shows.

19 Jul 2012

Nerve growth factors sense OAB in children

Researchers may have found a reliable biomarker for diagnosing overactive bladder in children and monitoring their treatment outcome.

18 Jul 2012

Alzheimer’s pathology lies silent for decades

The pathologic process of Alzheimer’s disease begins more than 20 years before clinical symptoms become apparent, say researchers.

18 Jul 2012

BJP publishes data from ESTEVE's E-52862 preclinical studies on pain

ESTEVE announces the recent publication in the British Journal of Pharmacology of important preclinical data that furthers understanding of its highly potent and selective, once-daily, S1R antagonist E-52862, developed by the ESTEVE Research and Development (R&D) team.

18 Jul 2012

UCB’s Neupro now available in U.S. pharmacies

UCB announced today that Neupro (Rotigotine Transdermal System) is now available in U.S. pharmacies. Neupro was approved by the U.S Food and Drug Administration in April to treat the signs and symptoms of early and advanced stage idiopathic Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome.

16 Jul 2012