Genes News and Research

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IU receives $1.9 million grant to investigate effects of congenital birth defects and age on the eye

A $1.9 million grant to Indiana University from the National Institutes of Health's National Eye Institute will advance basic research on the eye with applications to blindness caused by genetic disorders and aging.

20 Sep 2016

Researchers use computer modelling to identify mechanism behind aggressive brain tumours

Researchers at Uppsala University have used computer modelling to study how brain tumours arise.

19 Sep 2016

Researchers identify mutant traits in mouse for many human disease genes

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others. The study was published this week in Nature.

19 Sep 2016

Memory of heart attack can be stored in genes through epigenetic changes, study shows

Both heredity and environmental factors influence our risk of cardiovascular disease. A new study, by researches at Uppsala University, shows now that the memory of a heart attack can be stored in our genes through epigenetic changes.

19 Sep 2016

Researchers find switch that helps restore damaged axons

Researchers at the University of Wisconsin-Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons.

16 Sep 2016

Researchers explain novel approach for analyzing diverse immune responses

The response to infection is highly variable from one individual to another. The Milieu Intérieur consortium, coordinated by Prof. Matthew Albert (Immunobiology of dendritic cells Unit, Institut Pasteur / Inserm) and Dr Lluis Quintana-Murci (Human Evolutionary Genetics Unit, Institut Pasteur / CNRS) seek to establish the parameters that characterize the immune system of healthy individuals and its natural variability.

16 Sep 2016

Second-generation survivors whose parents were babies during Holocaust at high risk of severe schizophrenia

Results of a new study at the University of Haifa have found that no difference in the risk of developing schizophrenia between second-generations Holocaust survivors and those whose parents were not exposed to the Holocaust.

15 Sep 2016

Research findings point to potential new targeted therapy for SMA

For the first time, scientists found that in spinal muscular atrophy (SMA), the affected nerve cells that control muscle movement, or motor neurons, have defects in their mitochondria, which generate energy used by the cell.

15 Sep 2016

Researchers discover new genes with potential to improve adoptive T cell therapy

A Yale Cancer Center research team has identified that two genes, NR4A1 and ABC transporters, mark a distinct subset of quiescent T cells within human tissues, and have developed methods to mobilize them into circulation for potential application in adoptive T cell therapy of cancer.

15 Sep 2016

Researchers identify genes that regulate cellular senescence

A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief ENARI Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.

13 Sep 2016

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.

13 Sep 2016

New four-stranded version of DNA may hold key to development of targeted cancer therapies

Scientists have identified where a four-stranded version of DNA exists within the genome of human cells, and suggest that it may hold a key to developing new, targeted therapies for cancer.

13 Sep 2016

International researchers discover 44 novel gene sites linked to hypertension

In papers receiving advance online publication in Nature Genetics, two international multi-institutional research teams describe identifying a total of 44 novel gene sites associated with hypertension or high blood pressure.

13 Sep 2016

Combinational analysis of FISH and IHC detects NSCLC patients with rare ALK fusions

The combined use of fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) identified non-small cell lung cancer (NSCLC) patients with rare or novel anaplastic lymphoma kinase (ALK) gene rearrangements, not otherwise identified by FISH alone, that showed response to crizotinib treatment.

12 Sep 2016

Researchers uncover specific sites in the genome linked to high blood pressure

Three large, collaborating international consortia of researchers, including a team co-led by investigators from Brigham and Women's Hospital, have uncovered new genes and sites in the genome tied to elevated blood pressure, implicating certain biological pathways and pointing toward new therapeutic strategies for treating hypertension.

12 Sep 2016

Isolation of human NP cells may offer way to foster renal regeneration after chronic kidney failure

In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children's Hospital Los Angeles have isolated human nephron progenitor (NP) cells.

12 Sep 2016

Study shows increasing healthcare costs for infections linked to premise plumbing pathogens

A new analysis of 100 million Medicare records from U.S. adults aged 65 and older reveals rising healthcare costs for infections associated with opportunistic premise plumbing pathogens--disease-causing bacteria, such as Legionella--which can live inside drinking water distribution systems, including household and hospital water pipes.

12 Sep 2016

Heat shock proteins may play role in triggering Schistosoma invasion

A protein known for helping cells withstand stress may also act as a switch that triggers free-swimming Schistosoma larvae to begin penetrating the skin and transforming into the parasitic flatworms that burden more than 240 million people worldwide with schistosomiasis.

9 Sep 2016

UAB researchers find microRNA as potential therapeutic target for MDD

A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide.

9 Sep 2016

Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

For patients with advanced lung cancer, a non-invasive liquid biopsy may be a more effective and suitable alternative to the gold standard tissue biopsy to detect clinically relevant mutations and help guide their course of treatment, suggests a new study published this week in the journal Clinical Cancer Research from researchers at the Abramson Cancer Center at the University of Pennsylvania.

9 Sep 2016

Genes News and Research

IU receives $1.9 million grant to investigate effects of congenital birth defects and age on the eye

Researchers use computer modelling to identify mechanism behind aggressive brain tumours

Researchers identify mutant traits in mouse for many human disease genes

Memory of heart attack can be stored in genes through epigenetic changes, study shows

Researchers find switch that helps restore damaged axons

Researchers explain novel approach for analyzing diverse immune responses

Second-generation survivors whose parents were babies during Holocaust at high risk of severe schizophrenia

Research findings point to potential new targeted therapy for SMA

Researchers discover new genes with potential to improve adoptive T cell therapy

Researchers identify genes that regulate cellular senescence

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

New four-stranded version of DNA may hold key to development of targeted cancer therapies

International researchers discover 44 novel gene sites linked to hypertension

Combinational analysis of FISH and IHC detects NSCLC patients with rare ALK fusions

Researchers uncover specific sites in the genome linked to high blood pressure

Isolation of human NP cells may offer way to foster renal regeneration after chronic kidney failure

Study shows increasing healthcare costs for infections linked to premise plumbing pathogens

Heat shock proteins may play role in triggering Schistosoma invasion

UAB researchers find microRNA as potential therapeutic target for MDD

Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

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