Brain Cell News and Research

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UT Southwestern discovery may lead to new drug-abuse treatments

Increased connections among brain cells caused by excessive drug use may represent the body's defense mechanism to combat addiction and related behaviors, scientists at UT Southwestern Medical Center have found.

27 Aug 2008

New technique offers hope for stroke sufferers

If a stroke patient doesn't get treatment within approximately the first three hours of symptoms, there's not much doctors can do to limit damage to the brain.

25 Aug 2008

New therapeutic approaches to protect neurons from inflammation and toxicity-induced neurodegeneration

New research led by Chu Chen, PhD, Associate Professor of Neuroscience at LSU Health Sciences Center New Orleans, provides evidence that one of the only naturally occurring fatty acids in the brain that has the ability to interact with the receptors originally identified as the targets of THC (the psychoactive component of marijuana) can help to protect brain cells from neurodegenerative diseases like Alzheimer's and Parkinson's.

20 Aug 2008

First drug for Huntington's disease approved for use in the U.S.

Huntington's disease is a fatal, inherited neurodegenerative disorder for which there is no cure and usually affects people in their 30s and 40s, but some patients are affected as early as childhood, while others aren't affected until they are older.

18 Aug 2008

Variation in Ankyrin 3 gene shows strong association with bipolar disorder

The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association between the disorder and variation in two genes that make components of channels that manage the flow of the elements into and out of cells, including neurons.

17 Aug 2008

FDA approves tetrabenazine for Huntington's disease

The U.S. Food and Drug Administration has approved tetrabenazine, the first drug approved for use in the United States to treat Huntington's disease, a fatal, inherited neurodegenerative disorder for which there is no cure. The action comes about eight months after an advisory panel unanimously voted to advise FDA to make the medication available to treat the disease.

17 Aug 2008

Molecular switch provides insights into a form of altered brain activity occurring in schizophrenia

People with schizophrenia have an alteration in a pattern of brain electrical activity associated with learning and memory. Now, researchers from the National Institutes of Health and Sweden's Karolinska Institute have identified in mouse brain tissue a molecular switch that, when thrown, increases the strength of this electrical pattern. The researchers found that adding the brain chemical Neuregulin-1 to the brain tissue boosted the electrical signals that the tissue generated.

13 Aug 2008

Finding cancer's original cell key to treatments

Cancer biologists are turning their attention to the normal cells that give rise to cancers, to learn more about how tumor growth might be stopped at the earliest opportunity.

11 Aug 2008

Medulloblastoma originates in normal brain "stem" cells that turn malignant

An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

11 Aug 2008

Bristol University receives new funds for research into stress and the brain

Over £500,000 has been awarded to Bristol University academics to fund research into how stress hormones act in the brain.

11 Aug 2008

Oestrogen - a beneficial addition to treatment of schizophrenia in women

Australian scientists have found that women suffering from schizophrenia were less likely to suffer hallucinations or delusions, when the hormone oestrogen was added to their treatment.

4 Aug 2008

Research team creates human ALS motor neurons

A team of researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University, in a collaboration catalyzed by the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, has demonstrated that pluripotent stem cells generated from a patient with ALS (amyotrophic lateral sclerosis) can be directed to differentiate into motor neurons - the very brain cells destroyed by ALS.

31 Jul 2008

Study sheds light on why addiction is a chronic disease

Drug addiction dramatically shifts a person's attention, priorities, and behaviors towards a focus almost entirely on seeking out and taking drugs. Now, an animal study funded by the National Institute on Drug Abuse, part of the National Institutes of Health, has identified some of the specific long-term adaptations in the brain's reward system that may contribute to this shift.

31 Jul 2008

Unusual chromosomal changes increase the risk of schizophrenia

People with schizophrenia have an increased number of unusual chromosomal changes, particularly structural changes that have the potential to alter the function of the genes. These results were published today in the scientific journal Nature.

31 Jul 2008

microRNA may influence development of alcohol tolerance

In recent years, a class of small molecules known as microRNAs have been found to play an important role in regulating gene products in most animal and plant species.

30 Jul 2008

Rember, new Alzheimer's drug offers hope to sufferers

An experimental drug to treat Alzheimer's disease has had some promising results in early trials with patients.

30 Jul 2008

Markers in blood and spinal fluid, and a new imaging agent, show promise for early detection of Alzheimer's

With the continued aging of the population and the growing epidemic of Alzheimer's, early detection of the disease is crucial for risk assessment, testing new therapies, and eventual early intervention with better drugs, once they are developed. Four studies reported today at the Alzheimer's Association's 2008 International Conference on Alzheimer's Disease (ICAD 2008) in Chicago bring us closer to that goal of early detection by describing advances in biomarkers.

29 Jul 2008

Alzheimer's disease patients show improvement in trial of new drug

A new drug has been shown to improve the brain function of people with early stage Alzheimer's disease and reduce a key protein associated with the disease in the spinal fluid, in a small study published today in the journal Lancet Neurology and presented at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease.

29 Jul 2008

How anti-depressants and cocaine interact with brain

In a first, scientists from Weill Cornell Medical College and Columbia University Medical Center have described the specifics of how brain cells process antidepressant drugs, cocaine and amphetamines. These novel findings could prove useful in the development of more targeted medication therapies for a host of psychiatric diseases, most notably in the area of addiction.

28 Jul 2008

Exercise shown to slow down Alzheimer's progress

According to a new study, patients with the early signs of Alzheimer's disease had less deterioration in the areas of the brain which control memory, if they exercised regularly.

28 Jul 2008