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RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

A method for "silencing" RNA that emerged from a University of Wisconsin-Madison spinoff company is in clinical trials in Europe, Asia and the United States against hepatitis B, an infection that can destroy the liver.

11 Aug 2016

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

Research from investigators at Rutgers Cancer Institute of New Jersey and Princeton University has identified a new approach to cancer therapy in cutting off a cancer cell's 'fuel supply' by targeting a cellular survival mechanism known as autophagy.

11 Aug 2016

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis.

10 Aug 2016

Scientists explore neurobiological factors contributing to schizophrenia

Schizophrenic psychoses are a frequently occurring group of psychiatric disorders caused by a combination of biological, social and environmental factors.

10 Aug 2016

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2016

SBP researchers discover potential drug target for treatment of type 2 diabetes

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published today in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.

10 Aug 2016

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data.

10 Aug 2016

Understanding brain circuit development: an interview with Dr Hollis Cline

There's a tremendous amount known about brain circuit development. Our work was inspired by experiments that were done over 50 years ago by scientists at Harvard University, Hubel and Wiesel. They received a Nobel Prize for their work and have inspired many additional experiments over the last 50 or 60 years.

10 Aug 2016

Researchers develop computational algorithm to analyze big genomic data for different cancers

University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze "Big Data" obtained from tumor samples to better understand and treat cancer.

10 Aug 2016

Researchers develop machine-learning program that helps identify hundreds of ASD-related genes

Investigators eager to uncover the genetic basis of autism could now have hundreds of promising new leads thanks to a study by Princeton University and Simons Foundation researchers.

9 Aug 2016

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death.

9 Aug 2016

Research findings could lead to development of improved breast cancer drugs

Biomedical scientists have revealed the inner workings of a group of proteins that help to switch critical genes on and off during blood-cell production, in a finding that could lead to the development of new and improved cancer drugs.

9 Aug 2016

Sharing of patients' stem cells could boost bipolar disorder research

Stem cells from patients with bipolar disorder are being made available to scientists around the world to boost research into the condition.

9 Aug 2016

New Sequins technology could help improve quality of genomic analysis

Australian genomics researchers have announced the development of Sequins -- synthetic 'mirror' DNA sequences that reflect the human genome.

9 Aug 2016

Healthy adults who regularly exercise may be misdiagnosed with heart disease, study shows

Scientists have shown that people who exercise for even a few hours each week can enlarge their hearts. This is a normal and beneficial response to exercise, but until now has only been recognised in athletes.

9 Aug 2016

New study shows hedgehog signalling offers protection against colon cancer

Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway.

8 Aug 2016

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era.

8 Aug 2016

Reproductive age-related changes in ovarian environment may contribute to infertility

Women's decreased ability to produce healthy eggs as they become older may be due to excessive scarring and inflammation in their ovaries, reports a new Northwestern Medicine study in mice.

8 Aug 2016

UM SOM selected as study site for human safety trial of new Zika vaccine

As world leaders increasingly recognize the Zika virus as an international public health threat, the Center for Vaccine Development at the University of Maryland School of Medicine's Institute for Global Health has been chosen as one of three study sites in a human safety trial of a new Zika vaccine.

7 Aug 2016

Scientists unlock genetic code controlling limb regeneration

Many lower organisms retain the miraculous ability to regenerate form and function of almost any tissue after injury. Humans share many of our genes with these organisms, but our capacity for regeneration is limited.

5 Aug 2016

Genes News and Research

RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

Cutting off fuel to cancer cells may be potential therapeutic strategy for Kras-driven lung cancers

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Scientists explore neurobiological factors contributing to schizophrenia

Penn study sheds light on role of essential compound in maintaining optimal muscle function

SBP researchers discover potential drug target for treatment of type 2 diabetes

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Understanding brain circuit development: an interview with Dr Hollis Cline

Researchers develop computational algorithm to analyze big genomic data for different cancers

Researchers develop machine-learning program that helps identify hundreds of ASD-related genes

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Research findings could lead to development of improved breast cancer drugs

Sharing of patients' stem cells could boost bipolar disorder research

New Sequins technology could help improve quality of genomic analysis

Healthy adults who regularly exercise may be misdiagnosed with heart disease, study shows

New study shows hedgehog signalling offers protection against colon cancer

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Reproductive age-related changes in ovarian environment may contribute to infertility

UM SOM selected as study site for human safety trial of new Zika vaccine

Scientists unlock genetic code controlling limb regeneration

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