Genes News and Research

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Wistar scientists discover marker for PMN-MDSCs in the blood of cancer patients

Myeloid-derived suppressor cells (MDSCs) are a population of immune cells that have been implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

5 Aug 2016

Scientists make major advance in understanding how stem cells become specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse.

5 Aug 2016

Novel dual molecular tuner offers easy way to perform in-depth analyses in mammalian cells

A research team headed by investigators at the Icahn School of Medicine at Mount Sinai has developed a tool that allows scientists to quickly manipulate levels of two proteins in the same cell.

5 Aug 2016

Alcohol-craving rats offer insights into genetic underpinnings of alcoholism

Alcohol-craving rats have provided researchers with a detailed look into the complicated genetic underpinnings of alcoholism.

5 Aug 2016

Review provides new insights into diagnosis, treatment for PCOS

Polycystic ovary syndrome (PCOS) afflicts over 14 million women in the United States. The disorder increases the risk of endometrial cancer, heart disease, high blood pressure, type 2 diabetes, asthma, obesity, depression and anxiety, as well as infertility and a variety of reproductive disorders.

4 Aug 2016

New study analyzes evolution of epigenetic mechanisms from bacteria to humans

After the emergence of single-celled organisms some billions of years ago, nature started experimenting with how to diversify gene function without changing the sequence of the DNA, such that the blue print remains conserved, but allows gene products to have different functions.

4 Aug 2016

Amish farm environment protects children from asthma by shaping immune system

By probing the differences between two farming communities—the Amish of Indiana and the Hutterites of South Dakota—an interdisciplinary team of researchers found that specific aspects of the Amish environment are associated with changes to immune cells that appear to protect children from developing asthma.

4 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

Watch-and-wait approach means some patients could delay taking highly toxic non-curative anticancer drugs that come with substantial side effects

4 Aug 2016

New tool helps researchers make connections between proteins, genes, drugs and diseases

Every day, more than 3,000 new abstracts are uploaded to PubMed, the main biomedical literature reference database. Even in a researcher's narrowly-defined field, it is impossible to stay on top of the ever-evolving webs of interconnections between these papers.

4 Aug 2016

Combinations of FDA-approved drugs may prevent vision loss linked to retinal degeneration

Combinations of Food and Drug Administration-approved drugs protect against the loss of cells required for vision in a mouse model of blinding retinal diseases.

4 Aug 2016

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a clinical trial of a vaccine candidate intended to prevent Zika virus infection.

3 Aug 2016

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer Junghae Suh has been awarded a prestigious R01 grant by the National Institutes of Health to research the use of viral gene therapy to fight ovarian cancer.

3 Aug 2016

New drug treatment could reduce body weight in obese patients with rare genetic disorder

As part of a phase II study at Charité - Universitätsmedizin Berlin and the Berlin Institute of Health, two obese patients with a rare genetic disorder were given a drug treatment to stimulate the satiety center in the brain.

3 Aug 2016

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research.

3 Aug 2016

Genes News and Research

Wistar scientists discover marker for PMN-MDSCs in the blood of cancer patients

Scientists make major advance in understanding how stem cells become specialized

Novel dual molecular tuner offers easy way to perform in-depth analyses in mammalian cells

Alcohol-craving rats offer insights into genetic underpinnings of alcoholism

Review provides new insights into diagnosis, treatment for PCOS

New study analyzes evolution of epigenetic mechanisms from bacteria to humans

Amish farm environment protects children from asthma by shaping immune system

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

New tool helps researchers make connections between proteins, genes, drugs and diseases

Combinations of FDA-approved drugs may prevent vision loss linked to retinal degeneration

NIH launches clinical trial of experimental vaccine candidate for preventing Zika virus infection

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

New drug treatment could reduce body weight in obese patients with rare genetic disorder

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Scientists engineer therapeutic system with two arms to get better hold on cancer target

Biologists discover male-harming mtDNA mutant that substantiates mother's curse hypothesis

E. coli bacteria capable of beneficial mutations at more variable rates than previously thought

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

eBook: Using iPSCs models for human disease research and drug discovery eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics