Genes News and Research

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Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

A multi-center team of researchers in the U.S. testing the potential of cell therapy for treating Parkinson's disease (PD) has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human primates modeled with PD promoted behavioral recovery, increased dopamine concentrations in the brain, and induced the expression of beneficial genes and pathways when compared to control animals not transplanted with stem cells.

9 Jun 2016

Age may play major role in cell's ability to respond to physical exercise

If you're an older adult, a 30-minute workout may not be as effective, even at the cellular level, as it was when you were younger.

9 Jun 2016

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies.

8 Jun 2016

Yale researchers identify mechanisms responsible for human egg aging

Yale School of Medicine researchers have identified the molecular pathways involved in the aging of human eggs. This research could eventually lead to treatments to correct age-related damage and improve fertility in women age 40 and older.

8 Jun 2016

New mathematical model helps examine metabolism of breast epithelium

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling. This research, published in PLOS Computational Biology, may contribute to the development of cell specific anti-cancer interventions.

8 Jun 2016

New study sheds light on impact of unknown genetic mutations in cystic fibrosis patients

When it comes to cystic fibrosis (CF), more than 2,000 different genetic mutations have been reported. However, only 200 of them have been categorized - leaving a genetic soup of 1,800 others for scientists and genetic counselors to figure out.

8 Jun 2016

Study challenges notion of fear of weight gain in patients with anorexia nervosa

A study from Inserm, Paris Descartes University and Sainte Anne Hospital suggests that anorexia nervosa might not be explained by fear of gaining weight, but by the pleasure of losing it... and that the phenomenon might be genetically influenced.

8 Jun 2016

Scientists discover unexpected functions of snoRNAs that explains cause of some diseases

Scientists have discovered unexpected functions of small nucleolar RNAs (snoRNAs) that explain the cause of some diseases.

7 Jun 2016

New systems-based strategy may help accelerate TB drug discovery

The rise in multi-drug resistant (MDR) and extremely drug resistant (XDR) strains of Mycobacterium tuberculosis (MTB) is becoming a major cause of global health concern for treating tuberculosis, which affects a third of the global population.

7 Jun 2016

Researchers examine pan-genome of deadly Staph bacteria

Staphylococcus aureus bacteria are the leading cause of skin, soft tissue and several other types of infections. Staph is also a global public threat due to the rapid rise of antibiotic-resistant strains, including methicillin-resistant Staphylococcus aureus or MRSA.

7 Jun 2016

Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Otosclerosis is a common cause of hearing loss, particularly amongst young adults. It normally starts in their 20s or 30s and it affects about 1 in 200 hundred people. In the UK, about 300,000 people are affected by the condition.

7 Jun 2016

Epigenomic alterations play key role in triggering obesity-induced diabetes

Obesity is a risk factor for developing type 2 diabetes, yet not all obese humans develop the disease. In a new study, researchers from the Karolinska Institutet in Sweden and from the Institute of Health and Medical Research in France have identified epigenomic alterations that are associated with inflammation and type 2 diabetes

7 Jun 2016

Genes of healthy leanness could lead to new approach to treating obesity-related diabetes

People with type 2 diabetes could be helped by the discovery of a gene linked to leanness.

7 Jun 2016

Northwestern Medicine scientists link TMEM230 gene mutations to Parkinson's disease development

Northwestern Medicine scientists have discovered a new cause of Parkinson's disease -- mutations in a gene called TMEM230. This appears to be the third gene definitively linked to confirmed cases of the common movement disorder.

7 Jun 2016

Improved research tool may open door to effective HIV vaccine designs

Vaccines are usually medicine's best defense against the world's deadliest microbes. However, HIV is so mutable that it has so far effectively evaded both the human immune system and scientists' attempts to make an effective vaccine to protect against it.

6 Jun 2016

Rare DNA alteration may increase rsk of multiple sclerosis

Scientists at the University of British Columbia and Vancouver Coastal Health have proven that multiple sclerosis (MS) can be caused by a single genetic mutation - a rare alteration in DNA that makes it very likely a person will develop the more devastating form of the neurological disease.

6 Jun 2016

Giving chemotherapy after radiotherapy delays rare brain tumour growth

GIVING chemotherapy after radiotherapy delays further growth of a rare type of brain tumour, increasing the number of patients alive at five years from 44 per cent to 56 per cent.

6 Jun 2016

Early social deprivation may lower DNA methylation within stress-related genes

New research suggests that early severe social deprivation may impact DNA modifications that affect the expression of stress-related genes. These nongenetic (or epigenetic) modifications occur when molecules called methyl groups are added to components of DNA.

6 Jun 2016

Joint research reveals key mechanisms of persistent latent infection of HTLV-1

Joint research between scientists from Kumamoto University, Japan and Imperial College London, UK has revealed the mechanisms of persistent latent infection of the human T-cell leukemia virus type 1 (HTLV-1).

6 Jun 2016

Targeted therapy rucaparib shows promise in treating pancreatic cancer patients with BRCA mutation

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study presented by Susan M. Domchek, MD, executive director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, at the American Society of Clinical Oncology Annual Meeting.

6 Jun 2016

Genes News and Research

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

Age may play major role in cell's ability to respond to physical exercise

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Yale researchers identify mechanisms responsible for human egg aging

New mathematical model helps examine metabolism of breast epithelium

New study sheds light on impact of unknown genetic mutations in cystic fibrosis patients

Study challenges notion of fear of weight gain in patients with anorexia nervosa

Scientists discover unexpected functions of snoRNAs that explains cause of some diseases

New systems-based strategy may help accelerate TB drug discovery

Researchers examine pan-genome of deadly Staph bacteria

Unlocking the first gene to cause otosclerosis: an interview with Dr Ralph Holme

Epigenomic alterations play key role in triggering obesity-induced diabetes

Genes of healthy leanness could lead to new approach to treating obesity-related diabetes

Northwestern Medicine scientists link TMEM230 gene mutations to Parkinson's disease development

Improved research tool may open door to effective HIV vaccine designs

Rare DNA alteration may increase rsk of multiple sclerosis

Giving chemotherapy after radiotherapy delays rare brain tumour growth

Early social deprivation may lower DNA methylation within stress-related genes

Joint research reveals key mechanisms of persistent latent infection of HTLV-1

Targeted therapy rucaparib shows promise in treating pancreatic cancer patients with BRCA mutation

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