Clinical Trial News and Research

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Characterizing the spectrum of mitochondrial DNA deletion disease syndromes

Researchers from the Mitochondrial Medicine Program at Children's Hospital of Philadelphia (CHOP) have better characterized a spectrum of what were classically considered discrete mitochondrial DNA deletion disease syndromes.

21 Feb 2025

New clinical trial seeks alternatives for head and neck cancer patients unable to use cisplatin

A physician-scientist at the University of Oklahoma is part of an international effort seeking new options for patients with head and neck cancer who cannot receive the standard chemotherapy drug cisplatin.

21 Feb 2025

Breakthrough discovery unveils potential treatment for hepatitis B

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by Memorial Sloan Kettering Cancer Center (MSK), Weill Cornell Medicine and The Rockefeller University identified a vulnerability that opens the door to new treatments.

20 Feb 2025

Inhalable gene therapy tested for cystic fibrosis treatment in the UK and Europe

An inhalable medicine with the potential to improve lung disease in people with cystic fibrosis, irrespective of their mutation type, is being tested in human trials in the UK and Europe.

20 Feb 2025

Small amounts of exercise linked to lower dementia risk in older adults

A little movement could help prevent dementia, even for frail older adults, suggests a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

20 Feb 2025

CPRIT awards nearly $23 million to MD Anderson for cancer research projects

The University of Texas MD Anderson Cancer Center today was awarded nearly $23 million from the Cancer Prevention and Research Institute of Texas (CPRIT) in support of 20 cancer research projects to advance new breakthroughs in discovery, translational, clinical and prevention science.

20 Feb 2025

Breakthrough in gene therapy could help protect against heart arrhythmias

Cardiac arrhythmias affect millions across the world and are responsible for a fifth of all deaths in the Netherlands.

20 Feb 2025

Simple text-messaging system saves time for cancer patients during treatment visits

Cancer patients spend a lot of time on their care. Meeting with doctors and other members of their health care team, getting labs and other tests, picking up prescriptions, and undergoing treatment all takes time.

19 Feb 2025

Lifestyle and environmental factors play bigger role in health and premature death than genetics

A new study led by researchers from Oxford Population Health has shown that a range of environmental factors, including lifestyle (smoking and physical activity), and living conditions, have a greater impact on health and premature death than our genes.

19 Feb 2025

Nerinetide shows promise in stroke treatment meta-analysis

The Calgary Stroke Program, a joint University of Calgary and Alberta Health Services initiative at Foothills Medical Centre, has been involved with three papers published this week in The Lancet and Lancet Neurology-the ESCAPE-NEXT trial, the FRONTIER trial, and an individual patient-level meta-analysis across three trials.

19 Feb 2025

Radiation and immunotherapy help preserve bladders in patients with muscle-invasive bladder cancer

Patients with localized muscle-invasive bladder cancer (MIBC) who received radiation plus the immune checkpoint inhibitors (ICIs) durvalumab (Imfinzi) and tremelimumab (Imjudo) had durable responses that allowed for bladder preservation, according to results from the IMMUNOPRESERVE clinical trial.

18 Feb 2025

UTHealth Houston launches at-home telerehabilitation trial for stroke patients in Rio Grande Valley

A new at-home telerehabilitation care service for stroke patients will be offered to residents of Cameron County in the Rio Grande Valley as part of a randomized clinical trial led by researchers from across UTHealth Houston.

18 Feb 2025

FDA-approved osteoporosis drug may treat rare genetic heart disease

A research team co-led by scientists at the University of Arizona College of Medicine – Tucson found that an osteoporosis drug might counter a rare genetic mutation underlying a type of heart disease.

18 Feb 2025

Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment

A groundbreaking study in Nature Medicine reveals that GD2 CAR-T cell therapy can lead to long-term remission in children with neuroblastoma, with one patient remaining cancer-free for over 18 years.

17 Feb 2025

NIDUS-Family care package reduces dementia support costs

The NIDUS-Family package of care uses goal setting to help people with dementia live well at home for longer.

17 Feb 2025

AI tool speeds up patient screening for heart failure trials

Artificial intelligence (AI) can rapidly screen patients for clinical trial enrollment, according to a new study published in JAMA and led by Mass General Brigham researchers.

17 Feb 2025

Groundbreaking ALS platform trial accelerates research and drug testing

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with few treatment options. Since 2018, the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, has been working with national and international stakeholders to accelerate ALS research by launching the first platform trial in ALS to simultaneously test multiple drugs using shared trial infrastructure and placebo data.

17 Feb 2025

Sotagliflozin could be used to reduce the risk of deadly cardiovascular events, trial shows

Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidney disease with additional cardiovascular risk factors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher.

14 Feb 2025

UVA receives $9.3 million NIH grant for ketamine seizure treatment trial

University of Virginia Brain Institute and School of Medicine researchers have received an initial $9.3 million award from the National Institutes of Health for a $30 million clinical trial to determine if the powerful anesthetic ketamine can save patients from prolonged, life-threatening grand mal seizures that won't respond to other treatments.

14 Feb 2025

Addressing the global challenge of bacterial STIs

According to the World Health Organization (WHO), hundreds of millions of new cases of bacterial sexually transmitted infections (STIs) are reported worldwide each year. Many infections go undiagnosed due to their often silent symptoms, contributing to transmission, disease and complications such as infertility and miscarriage.

14 Feb 2025

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Clinical Trial News and Research

Characterizing the spectrum of mitochondrial DNA deletion disease syndromes

New clinical trial seeks alternatives for head and neck cancer patients unable to use cisplatin

Breakthrough discovery unveils potential treatment for hepatitis B

Inhalable gene therapy tested for cystic fibrosis treatment in the UK and Europe

Small amounts of exercise linked to lower dementia risk in older adults

CPRIT awards nearly $23 million to MD Anderson for cancer research projects

Breakthrough in gene therapy could help protect against heart arrhythmias

Simple text-messaging system saves time for cancer patients during treatment visits

Lifestyle and environmental factors play bigger role in health and premature death than genetics

Nerinetide shows promise in stroke treatment meta-analysis

Radiation and immunotherapy help preserve bladders in patients with muscle-invasive bladder cancer

UTHealth Houston launches at-home telerehabilitation trial for stroke patients in Rio Grande Valley

FDA-approved osteoporosis drug may treat rare genetic heart disease

Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment

NIDUS-Family care package reduces dementia support costs

AI tool speeds up patient screening for heart failure trials

Groundbreaking ALS platform trial accelerates research and drug testing

Sotagliflozin could be used to reduce the risk of deadly cardiovascular events, trial shows

UVA receives $9.3 million NIH grant for ketamine seizure treatment trial

Addressing the global challenge of bacterial STIs

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