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Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

UNC scientists develop new optogenetic tool to study function of different proteins

Scientists at the University of North Carolina School of Medicine have developed a way to embed light-responsive switches into proteins so that researchers can use lasers to manipulate protein movement and activity within living cells and animals.

19 Apr 2016

Study: British adults agree to donate heart, kidney and lungs, but not eyes for transplant

Despite a shortage of corneas for transplant purposes, new research reveals that eyes are the one body part we are least likely to donate.

19 Apr 2016

NanoString launches new nCounter Vantage assays that power 3D Biology experiments in cancer research

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced the introduction of nCounter Vantage, a portfolio of assays that power 3D Biology™ experiments in cancer research, including immuno-oncology.

From NanoString Technologies 19 Apr 2016

Sugar compounds provide nutrient support for growth of infant gut microbes

UC Davis researchers have shown that an enzyme produced by beneficial microbes in babies' intestines is able to harvest specific sugar compounds from human breast-milk and cow's milk. The discovery identifies those sugars -- rather than associated protein compounds -- as the key to nourishing those important, health-promoting microbes.

18 Apr 2016

UAB lab to offer new tests for genetic diseases using next-generation sequencing

The Medical Genomics Laboratory at the University of Alabama at Birmingham is expanding its technological array with a new panel of diagnostic tests for genetic diseases known as neurofibromatoses and rasopathies. Beginning April 18, the UAB lab will offer new tests using the technique called customized deep-coverage, next-generation sequencing or NGS.

18 Apr 2016

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

Using cutting-edge imaging technology, University of California, Irvine biologists have determined that uncontrolled fluctuations (known at "noise) in the concentration of the vitamin A derivative Retinoic acid (RA) can lead to disruptions in brain organization during development.

18 Apr 2016

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

One in 5,000 babies is born missing a small amount of genetic material from the tip of chromosome 1, a region called 1p36. Missing genes in the 1p36 region is a relatively common cause of intellectual disability.

18 Apr 2016

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

18 Apr 2016

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes and manages all of the information, including memories, that it takes in every day.

18 Apr 2016

Scientists identify human protein that weakens immune response to HIV, other viruses

Scientists at the University of North Carolina School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings, published today in Cell Host & Microbe, have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.

16 Apr 2016

Mouse model offers insight into molecular, neurological basis of stuttering

Mice that vocalize in a repetitive, halting pattern similar to human stuttering may provide insight into a condition that has perplexed scientists for centuries, according to a new study by researchers at Washington University School of Medicine in St. Louis and the National Institutes of Health.

16 Apr 2016

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

The removal of the enzyme Dnmt1 during oligodendrocyte progenitor cell (OPC) differentiation in the central nervous system resulted in inefficient myelin formation and neurological deterioration, including loss of control of bodily movements, in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal Cell Reports. The results could lead to a new understanding of multiple sclerosis and other myelin disorders in humans.

16 Apr 2016

FOXO proteins affect dozens of genes common to worms, flies, mice and humans

Whether a creature is a worm, a fly, a mouse, or a human, death inevitably awaits. And not only do these organisms share a common fate, but also, according to a new study, they may share some of the specific mechanisms of mortality. The researchers found that in all four species, there are 46 genes regulated by the same family of "FOXO" proteins known to be central in aging and longevity.

16 Apr 2016

Improving body clock could protect against metabolic syndrome

Essential biological processes are managed by an internal timer or body clock. When the body clock gets out of whack, conditions such as metabolic syndrome can occur.

15 Apr 2016

High dosages of antihistamines have dulling effect on genes associated with post-exercise recovery

After vigorous exercise, some 3,000 genes go to work to aid recovery by boosting muscles and blood vessels, but in the presence of high doses of antihistamines almost 27 percent of the gene response is blunted, according to University of Oregon researchers.

15 Apr 2016

UNIGE researchers identify PIGG gene that plays crucial role in recessive disease

The objective of genetic medicine is to analyze all the genes that make up the human genome, in order to identify as many genetic diseases as possible. Indeed, each gene variation has the potential to trigger specific defects.

15 Apr 2016

Study shows how homosexuality exists among humans throughout history

Around half of all heterosexual men and women potentially carry so-called homosexuality genes that are passed on from one generation to the next. This has helped homosexuality to be present among humans throughout history and in all cultures, even though homosexual men normally do not have many descendants who can directly inherit their genes.

13 Apr 2016

International scientists discuss new treatments for non small cell lung cancer

More than 30 prominent international scientists gathered to discuss the state-of-the-art, as well as promising future approaches for the treatment of lung cancer at the stunning 17th century Borgo San Luigi, in Monteriggion, in the heart of the Tuscany countryside.

13 Apr 2016

Moffitt study reports that liver metastases have different sensitivities to radiation therapy

Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumors maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient outcomes are unclear. Moffitt Cancer Center researchers report that liver metastases have different sensitivities to radiation therapy based on the location of the primary tumor.

13 Apr 2016

Genes News and Research

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

UNC scientists develop new optogenetic tool to study function of different proteins

Study: British adults agree to donate heart, kidney and lungs, but not eyes for transplant

NanoString launches new nCounter Vantage assays that power 3D Biology experiments in cancer research

Sugar compounds provide nutrient support for growth of infant gut microbes

UAB lab to offer new tests for genetic diseases using next-generation sequencing

Noise in concentration of vitamin A derivative RA can lead to disruptions in brain development

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

Scientists identify human protein that weakens immune response to HIV, other viruses

Mouse model offers insight into molecular, neurological basis of stuttering

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

FOXO proteins affect dozens of genes common to worms, flies, mice and humans

Improving body clock could protect against metabolic syndrome

High dosages of antihistamines have dulling effect on genes associated with post-exercise recovery

UNIGE researchers identify PIGG gene that plays crucial role in recessive disease

Study shows how homosexuality exists among humans throughout history

International scientists discuss new treatments for non small cell lung cancer

Moffitt study reports that liver metastases have different sensitivities to radiation therapy

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