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Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

Genome sequencing shows association between STIs and Trachoma

For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world's leading infectious cause of blindness, according to a study in Nature Communications.

26 Feb 2016

Japanese bioengineers tweak E. coli genes to pump out morphine precursor

A common gut microbe could soon be offering us pain relief. Japanese bioengineers have tweaked Escherichia coli genes so that they pump out thebaine, a morphine precursor that can be modified to make painkillers. The genetically modified E. coli produces 300 times more thebaine with minimal risk of unregulated use compared to a recently developed method involving yeast.

26 Feb 2016

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

An international research team has identified four likely new subtypes of a rare brain tumor using molecular techniques that lay the foundation for more accurate diagnosis and tailored therapies for the hard-to-treat cancer. Scientists at St. Jude Children's Research Hospital and the German Cancer Research Center led the study, results of which appear today in the scientific journal Cell.

26 Feb 2016

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and treatments.

25 Feb 2016

New anti-ageing therapy may be effective against aplastic anaemia

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an important link with the ageing process: the shortening of telomeres, structures that protect the ends of chromosomes.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

A patient with recurrent metastatic colorectal cancer has been successfully treated with the angiotensin receptor blocker irbesartan, researchers report.

24 Feb 2016

IMP's Johannes Zuber receives German Cancer Prize 2016

Johannes Zuber, group leader at the Research Institute of Molecular Pathology (IMP) in Vienna, receives the German Cancer Prize 2016 in the category of experimental cancer research.

24 Feb 2016

Investigating mechanism behind development of high-grade serous ovarian cancer

Rutgers Cancer Institute of New Jersey researcher Michael L. Gatza, PhD, has received a $747,000 Pathway to Independence Award (R00-CA166228) from the National Cancer Institute to explore the mechanism behind the development of a subtype of ovarian cancer known as high-grade serous ovarian cancer.

24 Feb 2016

Study reveals role of 'Kurly' protein found in cilia

A new study of a protein found in cilia - the hair-like projections on the cell surface - may help explain how genetic defects in cilia play a role in developmental abnormalities, kidney disease and a number of other disorders.

24 Feb 2016

Cells with higher fat content live longer than lean cells

Cells with higher fat content outlive lean cells, says a new study from Michigan State University.

24 Feb 2016

Study: Migraine, tension-type headaches may share genetic links with IBS

Migraine and tension-type headaches may share genetic links with irritable bowel syndrome (IBS), according to a preliminary study released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

24 Feb 2016

New TAU study suggests potential therapeutic pathway to keep osteosarcoma lesions dormant

Osteosarcoma is a cancer that develops in the bones of children and adolescents. It is one of the most aggressive cancers, with only a 15 per cent, five-year survival rate when diagnosed in an advanced metastatic stage. There are approximately 800 new cases diagnosed each year in the US, and no viable treatments.

23 Feb 2016

Texas Children's Hospital, Houston Methodist Hospital jointly release country's first rapid test for Zika virus

Collaboration between two Texas Medical Center institutions has resulted in today's release of the country's first hospital-based rapid tests for the Zika virus.

23 Feb 2016

MDI Biological Laboratory scientist identifies potential drug therapy to reverse peripheral nerve damage

The Mount Desert Island Biological Laboratory has announced that assistant professor Sandra Rieger, Ph.D., has identified two drugs that could potentially be used to reverse peripheral nerve damage, or peripheral neuropathy, resulting from chemotherapy treatment for ovarian, breast, lung, pancreas and other cancers. The drugs also have potential applications for the treatment of peripheral nerve damage caused by diabetes, traumatic injuries and other conditions.

23 Feb 2016

Hiroshima University researchers identify new class of cancer-causing genetic variations

Researchers at Hiroshima University have opened the door to finding a new class of cancer-causing genetic variations.

23 Feb 2016

UCSF study finds specific molecular-genetic mechanism that links sleep and seasonal depression

A newly discovered human gene mutation appears to contribute both to unusual sleep patterns and to heightened rates of seasonal depression, according to new research from UC San Francisco.

23 Feb 2016

Consuming dried plums can protect from radiation-induced bone loss

Dr. Nancy Turner, a Texas A&M AgriLife Research scientist in College Station, was one of a team of researchers who recently studied different interventions to protect from radiation-induced bone loss.

23 Feb 2016

Maternal supplementation with docosahexaenoic acid improves fetal iron metabolism

A research has proven, for the first time, that maternal supplementation with docosahexaenoic acid (DHA), an omega-3 essential polyunsaturated fatty acid, enhances fetal iron metabolism thanks to a greater expression of key genes regulating its transfer through the placenta.

23 Feb 2016

Genes News and Research

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Genome sequencing shows association between STIs and Trachoma

Japanese bioengineers tweak E. coli genes to pump out morphine precursor

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

New anti-ageing therapy may be effective against aplastic anaemia

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

IMP's Johannes Zuber receives German Cancer Prize 2016

Investigating mechanism behind development of high-grade serous ovarian cancer

Study reveals role of 'Kurly' protein found in cilia

Cells with higher fat content live longer than lean cells

Study: Migraine, tension-type headaches may share genetic links with IBS

New TAU study suggests potential therapeutic pathway to keep osteosarcoma lesions dormant

Texas Children's Hospital, Houston Methodist Hospital jointly release country's first rapid test for Zika virus

MDI Biological Laboratory scientist identifies potential drug therapy to reverse peripheral nerve damage

Hiroshima University researchers identify new class of cancer-causing genetic variations

UCSF study finds specific molecular-genetic mechanism that links sleep and seasonal depression

Consuming dried plums can protect from radiation-induced bone loss

Maternal supplementation with docosahexaenoic acid improves fetal iron metabolism

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